First detection of highly pathogenic H5N6 avian influenza virus on the African continent
Emerging Microbes and Infections, 2020 Since 2013, highly pathogenic avian influenza (HPAI) subtype H5N6 (clade 2.3.4.4) has been reported in wild birds and poultry in Asia as well as in other parts of the globe. In Africa, information on the presence of this virus subtype is lacking.
Ismaila Shittu +15 more
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Phylogenetic and Pathogenic Analysis of H5N1 and H5N6 High Pathogenicity Avian Influenza Virus Isolated from Poultry Farms (Layer and Broiler Chickens) in Japan in the 2023/2024 Season. [PDF]
VirusesDuring the 2023–2024 winter, 11 high pathogenicity avian influenza (HPAI) outbreaks caused by clade 2.3.4.4b H5N1 and H5N6 HPAI viruses were confirmed in Japanese domestic poultry among 10 prefectures (n = 10 and 1, respectively). In this study, we aimed
Nishiura H +7 more
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Infection Tracing and Virus Genomic Analysis of Two Cases of Human Infection with Avian Influenza A(H5N6) - Fujian Province, China, April-May 2024. [PDF]
China CDC WklyWhat is known about this topic? Global human cases of zoonotic influenza A(H5N6) have increased significantly in recent years, primarily due to widespread circulation of clade 2.3.4.4b virus since 2020.
Zhang Y +7 more
europepmc +2 more sources
Phosphorylation of S-S-S Motif in Nuclear Export Protein (NEP) Plays a Critical Role in Viral Ribonucleoprotein (vRNP) Nuclear Export of Influenza A and B Viruses. [PDF]
Adv Sci (Weinh)The phosphorylation of S‐S‐S motif on influenza virus NEP is required for NEP interaction with CRM1 thereby mediating vRNP nuclear export, which can be regulated by the kinase ATM and CK2. Impairment of phosphorylation on NEP S‐S‐S motif significantly suppresses virus replication and reduces the virulence in mice.
Liu X +6 more
europepmc +2 more sources
Molecular surveillance of avian influenza A (H5N6) virus in Quangbinh province, Vietnam
Bulgarian Journal of Veterinary Medicine, 2023 The haemagglutinin (HA) gene of highly pathogenic (HP) avian influenza H5Nx viruses (AIVs) has undergone continuous evolution, generating emerging reassorted subtypes and clades.
H. M. Pham, K. H. Pham, K. V. Nguyen
semanticscholar +2 more sources
Microbiology Spectrum, 2022 For an investigation into the effects of glycosylation site modification on hemagglutinin (HA) on the biological characteristics of the H5N6 subtype avian influenza virus (AIV), the HA sequences of H5N6 AIVs from Global Initiative on Sharing All ...
Nuo Xu +9 more
doaj +1 more source
139D in NS1 Contributes to the Virulence of H5N6 Influenza Virus in Mice [PDF]
Frontiers in Veterinary Science, 2022 H5N6, the highly pathogenic avian influenza A virus (IAV) of clade 2.3.4.4, causes global outbreaks in poultry. H5N6 has become the dominant IAV subtype in waterfowls and causes human infections with high mortality rates. Here, we isolated two strains of H5N6, XGD and JX, from chickens and ducks, respectively.
Kun Huang +20 more
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International Journal of Infectious Diseases, 2021 Objectives: The continuous evolution of highly pathogenic H5N6 avian influenza viruses (AIVs) causes outbreaks in wildfowl and poultry, and occasional human infections.
Fan Yang +6 more
doaj +1 more source
Influenza A(H5N6) Virus Reassortant, Southern China, 2014 [PDF]
Emerging Infectious Diseases, 2015 To the Editor: Avian influenza A viruses generally do not cause disease in aquatic birds, the natural reservoir of these viruses (1). Influenza A(H5N6) was first isolated from mallards by Garcia et al. in 1975 (2). Influenza viruses continue to evolve and reassort to generate novel, highly pathogenic viruses.
Hanqin Shen +4 more
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iScience, 2022 Summary: Avian influenza H5N6 virus not only wreaks economic havoc in the poultry industry but also threatens human health. Strikingly, as of August 2022, 78 human beings were infected with H5N6, and the spike in the number of human infections with H5N6 ...
Jiahao Zhang +10 more
doaj +1 more source