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Complex Evolutionary Dynamics of H5N8 Influenza A Viruses Revealed by Comprehensive Reassortment Analysis [PDF]

Viruses
Influenza A viruses (IAVs) circulate among different species and have the potential to cause significant pandemics in humans. This study focuses on reassortment events in the H5N8 subtype of IAV, which poses a serious threat to public health due to its ...
Egor Degtyarev, Sofia Feoktistova, Pavel Volchkov, Andrey Deviatkin   +3 more
doaj   +2 more sources

Construction and Immune Strategy Optimization of a Vaccine Strain for Influenza A (H5N8) Subtype [PDF]

Viruses
Multiple subtypes of avian influenza virus (AIV), including H5N1, H5N6, and H5N8 viruses, are currently co-circulating in wild birds and poultry and causing sporadic human infections. Vaccine development is essential for pandemic preparedness.
Shuxia Zhang, Jing Tang, Liqi Liu, Hejiang Wei, Li Xin, Kang Xiao, Jinbo Xiao, Jie Dong, Zi Li, Hongyan Bai, Shuaixing Wang, Wenfei Zhu, Lei Yang, Shumei Zou, Dayan Wang   +14 more
doaj   +2 more sources

Lack of virological and serological evidence for continued circulation of highly pathogenic avian influenza H5N8 virus in wild birds in the Netherlands, 14 November 2014 to 31 January 2016 [PDF]

, 2016
In 2014, H5N8 clade 2.3.4.4 highly pathogenic avian influenza (HPAI) viruses of the A/Goose/ Guangdong/1/1996 lineage emerged in poultry and wild birds in Asia, Europe and North America.
Bestebroer, T.M. (Theo), Brown, I.H. (Ian), Fouchier, R.A.M. (Ron), Grund, C., Kleyheeg, E. (Erik), Majoor, F. (Frank), Manvell, R.J., Müskens, G.J.D.M., Nolet, B.A. (Bart), Poen, M.J. (Marjolein), Scheuer, R.D., van der Jeugd, H.P., Verhagen, J.H. (Josanne), Vliet, S. (Stefan) van der, Vuong, O. (Oanh)   +14 more
core   +19 more sources

Impact of Individual Viral Gene Segments from Influenza A/H5N8 Virus on the Protective Efficacy of Inactivated Subtype-Specific Influenza Vaccine

Pathogens, 2021
Since its emergence in 2014, the highly pathogenic avian influenza H5N8 virus has continuously and rapidly spread worldwide in the poultry sector resulting in huge economic losses.
Yassmin Moatasim, Ahmed Kandeil, Ahmed Mostafa, Omnia Kutkat, Mohamed El Sayes, Ahmed N. El Taweel, Maha AlKhazindar, Elsayed T. AbdElSalam, Rabeh El-Shesheny, Ghazi Kayali, Mohamed A. Ali   +10 more
doaj   +1 more source

Divergent Reassortment and Transmission Dynamics of Highly Pathogenic Avian Influenza A(H5N8) Virus in Birds of China During 2021

Frontiers in Microbiology, 2022
Highly pathogenic influenza A(H5N8) viruses had caused several outbreaks among wild bird and poultry populations across the globe, and strikingly, caused human infection, posing serious public health concerns.
Hejia Ye, Hejia Ye, Jiahao Zhang, Jiahao Zhang, Jiahao Zhang, Yunfen Sang, Yunfen Sang, Yunfen Sang, Nan Shan, Weihong Qiu, Wenting Zhong, Junbao Li, Zhaoxia Yuan, Zhaoxia Yuan   +13 more
doaj   +1 more source

Molecular Epidemiology and Evolutionary Analysis of Avian Influenza A(H5) Viruses Circulating in Egypt, 2019–2021

Viruses, 2022
The highly pathogenic avian influenza (HPAI) H5N8 virus was first detected in Egypt in late 2016. Since then, the virus has spread rapidly among different poultry sectors, becoming the dominant HPAI H5 subtype reported in Egypt.
Naglaa M. Hagag, Nahed Yehia, Mohamed H. El-Husseiny, Amany Adel, Azhar G. Shalaby, Neveen Rabie, Mohamed Samy, Motaz Mohamed, Amal S. A. El-Oksh, Abdullah Selim, Abdel-Satar Arafa, Samah Eid, Momtaz A. Shahein, Mahmoud M. Naguib   +13 more
doaj   +1 more source

The C-terminus of non-structural protein 1 (NS1) in H5N8 clade 2.3.4.4 avian influenza virus affects virus fitness in human cells and virulence in mice

Emerging Microbes and Infections, 2021
Avian influenza viruses (AIV) H5N8 clade 2.3.4.4 pose a public health threat but the viral factors relevant for its potential adaptation to mammals are largely unknown.
Claudia Blaurock, Ulrike Blohm, Christine Luttermann, Julia Holzerland, David Scheibner, Alexander Schäfer, Allison Groseth, Thomas C. Mettenleiter, Elsayed M. Abdelwhab   +8 more
doaj   +1 more source

Epidemiology, Genetic Characterization, and Pathogenesis of Avian Influenza H5N8 Viruses Circulating in Northern and Southern Parts of Egypt, 2017–2019

Animals, 2021
Highly pathogenic avian influenza (HPAI) viruses of subtype H5N8 continue to circulate, causing huge economic losses and serious impact on poultry production worldwide.
Mohamed Tarek, Mahmoud M. Naguib, Abdel-Sattar Arafa, Laila A. Tantawy, Karim M. Selim, Shaimaa Talaat, Hesham A. Sultan   +6 more
doaj   +1 more source

Highly Pathogenic Avian Influenza A(H5N8) Clade 2.3.4.4b Viruses in Satellite-Tracked Wild Ducks, Ningxia, China, 2020

Emerging Infectious Diseases, 2022
During October 2020, we identified 13 highly pathogenic avian influenza A(H5N8) clade 2.3.4.4b viruses from wild ducks in Ningxia, China. These viruses were genetically related to H5N8 viruses circulating mainly in poultry in Europe during early 2020 ...
Xinru Lv, Xiang Li, Heting Sun, Yi Li, Peng Peng, Siyuan Qin, Weidong Wang, Yuecheng Li, Qing An, Tian Fu, Fengyi Qu, Qiuzi Xu, Rongxiu Qin, Zhenliang Zhao, Meixi Wang, Yulong Wang, Yajun Wang, Xiangwei Zeng, Zhijun Hou, Chengliang Lei, Dong Chu, Yanbing Li, Hongliang Chai   +22 more
doaj   +1 more source

Novel Clade 2.3.4.4b Highly Pathogenic Avian Influenza A H5N8 and H5N5 Viruses in Denmark, 2020

Viruses, 2021
Since late 2020, outbreaks of H5 highly pathogenic avian influenza (HPAI) viruses belonging to clade 2.3.4.4b have emerged in Europe. To investigate the evolutionary history of these viruses, we performed genetic characterization on the first HPAI ...
Yuan Liang, Jakob N. Nissen, Jesper S. Krog, Solvej Ø. Breum, Ramona Trebbien, Lars E. Larsen, Charlotte K. Hjulsager   +6 more
doaj   +1 more source