Results 81 to 90 of about 3,090 (189)

Complex population genetic structure of the bark beetle predator Thanasimus formicarius (L.) (Coleoptera: Cleridae) across its European range

Agricultural and Forest Entomology, Volume 27, Issue 3, Page 437-451, August 2025.
Abstract Thanasimus formicarius (L.) (Coleoptera: Cleridae) is an important bark beetle predator and can reduce bark beetle population densities of some of the most severe forest pests in Europe. We analysed the population genetics and phylogeography of T.
Eva Papek, Amina Derlić, Markus Melin, Alain Roques, Dragos Cocos, Martin L. Schroeder, Milan Pernek, Dimitrios N. Avtzis, Paulius Zolubas, David T. Williams, Juan A. Pajares, Oğuzhan Sarikaya, Roman Pavlin, Sevdalin Belilov, Martin M. Gossner, M. Lukas Seehausen, Anna Wierzbicka, Lara Kundtner, Christian Stauffer, Martin Schebeck   +19 more
wiley   +1 more source

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies

, 2013
PU-H71 is a purine-scaffold Hsp90 inhibitor that, in contrast to other Hsp90 inhibitors, displays unique selectivity for binding the fraction of Hsp90 that is preferentially associated with oncogenic client proteins and enriched in tumor cells (teHsp90).
Cesarman, Ethel, L. Goldstein, Rebecca, Lu, Pin, Chiosis, Gabriela, Taldone, Tony, Lynn Wang, Y., Cerchietti, Leandro, Ballon, Gianna, Rodina, Anna, Melnick, Ari, Goldstein, Rebecca L, Blasberg, Ronald, Vider, Jelena, Wang, Y Lynn, Erdjument-Bromage, Hediye, Nayar, Utthara, Chomet, Max   +16 more
core   +1 more source

A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

Aging Cell, Volume 24, Issue 7, July 2025.
This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante, Luca Cis, Davide Pirolli, Michela Gottardi Zamperla, Veronica Barbi, Antonello Mai, Clemens Zwergel, Serena Marcozzi, Maria Elisa Giuliani, Giorgia Bigossi, Giovanni Lai, Fiorenza Orlando, Robertina Giacconi, Fabrizia Lattanzio, Giulia Matacchione, Chiara Giordani, Massimo Bracci, Fabiola Olivieri, Federico Boschi, Paola Tabarelli De Fatis, Giovanni Battista Ivaldi, Marco Malavolta, Antonella Farsetti, Maria Cristina De Rosa, Carlo Gaetano   +24 more
wiley   +1 more source

Efficacy of Bacillus thuringiensis jordanica against Meloidogyne javanica Infecting Tomato

Phytopathologia Mediterranea, 2006
A local strain of Bacillus thuringiensis jordanica (Btj), serotype H71, was evaluated for its efficacy in controlling Meloidogyne javanica attacking tomato.
H. Khyami-Horani, L. Al-Banna
doaj   +1 more source

A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy

, 2017
Reprogramming of mitochondrial functions sustains tumor growth and may provide therapeutic opportunities. Here, we targeted the protein folding environment in mitochondria by coupling a purine-based inhibitor of the molecular chaperone Heat Shock Protein-
Elokely, Khaled M., Abou-Gharbia, Magid, Martinez, RL, Chae, YC, Kelly G. Bryant, Gordon, JC, Andrew V. Kossenkov, Steven Grant, Elokely, KM, Childers, WE, Martinez, Rogelio L., Grant, Steven, Elokely, Khaled M.|, Kossenkov, AV, Dario C. Altieri, Bryant, Kelly G., Wayne E. Childers, Rogelio L. Martinez, Khaled M. Elokely, Magid Abou-Gharbia, Grant, S, Kossenkov, Andrew V., Altieri, Dario C., Childers, Wayne E., Altieri, DC, Chae, Young Chan, Bryant, KG, John C. Gordon, Abou-Gharbia, M, Gordon, John C., Young Chan Chae   +30 more
core   +1 more source

Role of Exosome in Solid Cancer Progression and Its Potential Therapeutics in Cancer Treatment

Cancer Medicine, Volume 14, Issue 9, May 2025.
Exosomes are small extracellular vesicles that facilitate cellular communication and play a significant role in cancer progression by transferring molecules like miRNA and lncRNA within the tumor microenvironment. This review explores how exosomes derived from various cells influence solid cancer growth by activating pathways critical to tumor ...
Nada Aakel, Rawdhah Mohammed, Aseela Fathima, Rabia Kerzabi, Atiyeh Abdallah, Wisam Nabeel Ibrahim   +5 more
wiley   +1 more source

A step-wise selection method obtained the PfHsp90 Thr163Pro mutant (strain Dd2).

, 2013
(A) The Thr163Pro mutation is depicted computationally in the crystal structure of the PfHsp90 ATP-binding domain [45]. (B) The presence of this mutation resulted in doubling of the PU-H71 IC50 in the cell-based assay (a single representative experiment ...
Dylan R. Pillai (239521), Tony Taldone (254206), Dea Shahinas (424013), Asongna Folefoc (464670), Gabriela Chiosis (254214), Ian Crandall (78768)   +5 more
core   +1 more source

Squamocin Suppresses Tumor Growth through Triggering an Endoplasmic Reticulum Stress‐Associated Degradation of EZH2/MYC Axis

Advanced Science, Volume 12, Issue 15, April 17, 2025.
Squamocin disrupts mitochondrial respiratory Complex I function, reduces ATP production, and impairs HSP90α function, provoking endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in multiple cancer tumor models cell lines and in vivo tumor models.
Yin Zhu, Yurui Liu, Xiangtao Wang, Zhifeng Chen, Baojian Chen, Bingxin Hu, Tiane Tang, Haoran Cheng, Xinglong Liu, Yunshan Ning   +9 more
wiley   +1 more source

Can the Laffer curve become a policy tool for reducing tax evasion? Stratification of property tax collection by land use

Journal of Urban Management, 2019
We construct Laffer curves to evaluate the efficiency of local property tax collection based on a micro-level panel dataset referring to 2013–2016 and obtained from the Jerusalem municipality.
Yuval Arbel, Chaim Fialkoff, Amichai Kerner   +2 more
doaj   +1 more source

Impact of fuel subsidies on economic growth in energy-exporting countries: analysis with panel data

Studia Ekonomiczne i Regionalne
This study aims to measure the impact of fuel subsidy on economic growth in 2010-2020.
Samir Laissouf, Kamel Lahouel
doaj   +1 more source