Results 71 to 80 of about 3,267 (182)

Measuring fiscal disparities and equalization performance across Czech regions

Journal of Economics and Management
Aim/purpose – This article evaluates the proposed reform of the Czech regional tax-sharing system by examining how replacing the current system based on historical shares (S0) with the proposed criteria-based formula (S1) would affect the distribution of
Szarowská Irena
doaj   +1 more source

Can the Laffer curve become a policy tool for reducing tax evasion? Stratification of property tax collection by land use

Journal of Urban Management, 2019
We construct Laffer curves to evaluate the efficiency of local property tax collection based on a micro-level panel dataset referring to 2013–2016 and obtained from the Jerusalem municipality.
Yuval Arbel, Chaim Fialkoff, Amichai Kerner   +2 more
doaj   +1 more source

Impact of fuel subsidies on economic growth in energy-exporting countries: analysis with panel data

Studia Ekonomiczne i Regionalne
This study aims to measure the impact of fuel subsidy on economic growth in 2010-2020.
Samir Laissouf, Kamel Lahouel
doaj   +1 more source

Targeting Plasmodium falciparum Heat Shock Protein 90 (PfHsp90): A Strategy to Reverse Antimalarial Resistance [PDF]

, 2012
Drug resistance is one of the major impediments to control Plasmodium falciparum malaria worldwide. Heat shock protein 90 (Hsp90) is an essential component of the buffering capacity of eukaryotic cells as a part of the stress response. P.
Shahinas, Dea
core   +2 more sources

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies

, 2013
PU-H71 is a purine-scaffold Hsp90 inhibitor that, in contrast to other Hsp90 inhibitors, displays unique selectivity for binding the fraction of Hsp90 that is preferentially associated with oncogenic client proteins and enriched in tumor cells (teHsp90).
Cesarman, Ethel, L. Goldstein, Rebecca, Lu, Pin, Chiosis, Gabriela, Taldone, Tony, Lynn Wang, Y., Cerchietti, Leandro, Ballon, Gianna, Rodina, Anna, Melnick, Ari, Goldstein, Rebecca L, Blasberg, Ronald, Vider, Jelena, Wang, Y Lynn, Erdjument-Bromage, Hediye, Nayar, Utthara, Chomet, Max   +16 more
core   +1 more source

Las aglomeraciones urbanas y los impuestos: algunas ideas derivadas de la aplicación de la curva de Laffer al impuesto sobre la renta español en diferentes escenarios espaciales

El Trimestre Económico, 2017
Antecedentes: La búsqueda de las tasas impositivas óptimas ha sido recurrente en las discusiones de política fiscal. En particular, la relación entre la estructura tributaria y el crecimiento económico ha hecho resurgir la ...
Laura Varela-Candamio, Fernando Rubiera Morollón   +1 more
doaj  

A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy

, 2017
Reprogramming of mitochondrial functions sustains tumor growth and may provide therapeutic opportunities. Here, we targeted the protein folding environment in mitochondria by coupling a purine-based inhibitor of the molecular chaperone Heat Shock Protein-
Elokely, Khaled M., Abou-Gharbia, Magid, Martinez, RL, Chae, YC, Kelly G. Bryant, Gordon, JC, Andrew V. Kossenkov, Steven Grant, Elokely, KM, Childers, WE, Martinez, Rogelio L., Grant, Steven, Elokely, Khaled M.|, Kossenkov, AV, Dario C. Altieri, Bryant, Kelly G., Wayne E. Childers, Rogelio L. Martinez, Khaled M. Elokely, Magid Abou-Gharbia, Grant, S, Kossenkov, Andrew V., Altieri, Dario C., Childers, Wayne E., Altieri, DC, Chae, Young Chan, Bryant, KG, John C. Gordon, Abou-Gharbia, M, Gordon, John C., Young Chan Chae   +30 more
core   +1 more source

Phase 1b Study of the Epichaperome Inhibitor PU-H71 Administered Orally with Ruxolitinib Continuation for the Treatment of Patients with Myelofibrosis

Blood, 2019
Background: Myelofibrosis (MF) is a life-threatening disease characterized by splenomegaly, constitutional symptoms, and shortened survival. Although ruxolitinib, a JAK1/2 inhibitor, is approved for Intermediate or High-risk MF and can reduce the spleen size and improve quality of life, many patients discontinue due to loss of efficacy.
Naveen Pemmaraju, Krishna Gundabolu, Kristen Pettit, Moshe Talpaz, Nikolai A. Podoltsev, Gary J. Schiller, Peter Eisenberg, Hagop Youssoufian, Susan Duggan, Barbara Wallner, Srdan Verstovsek   +10 more
openaire   +1 more source

A step-wise selection method obtained the PfHsp90 Thr163Pro mutant (strain Dd2).

, 2013
(A) The Thr163Pro mutation is depicted computationally in the crystal structure of the PfHsp90 ATP-binding domain [45]. (B) The presence of this mutation resulted in doubling of the PU-H71 IC50 in the cell-based assay (a single representative experiment ...
Dylan R. Pillai (239521), Tony Taldone (254206), Dea Shahinas (424013), Asongna Folefoc (464670), Gabriela Chiosis (254214), Ian Crandall (78768)   +5 more
core   +1 more source

PTPN11 Mutated Acute Myeloid Leukemia (AML) Features an Abundant Epichaperome Network and Is Sensitive to the Epichaperome Inhibitor PU-H71

Blood, 2019
PTPN11 mutations occur in roughly 5-10% of AML patients. There is no defined impact on prognosis in the literature, although a single center analysis from our group suggested an association with poor outcomes. The pathogenesis of activating PTPN11 mutations is hypothesized to result in increased signaling through RAS resulting in uncontrolled cellular ...
Justin D. Kaner, Montreh Tavakkoli, Lisa Toudic, Brett M. Stevens, Craig T Jordan, Tony Taldone, Gabriela Chiosis, Ellen K. Ritchie, Pinkal Desai, Michael B. Samuel, Sangmin Lee, Gail J. Roboz, Monica L. Guzman   +12 more
openaire   +1 more source