Results 51 to 60 of about 3,267 (182)
The effect of intra-peritoneal PU-H71 administration on the Plasmodium berghei mouse model.
, 2013 Mice were infected on day 0 and treatment was started on day 5 at a parasitemia of 1%. (A–D) Average parasitemia levels in response to drug treatments alone or in combination with CQ are indicated (n = 4 animals).
Dylan R. Pillai (239521) +5 more
core +1 more source
International Journal of Quantum Chemistry, Volume 126, Issue 12, June 15, 2026.DFT (GGA) analysis reveals that the Rh‐Met metallodrug forms a stable ionic pair driven by a network of supramolecular interactions. QTAIM and IGMH insights elucidate the quantum‐mechanical nature of intra‐ and intermolecular contacts governing its self‐assembly and structural organization in the crystal. ABSTRACT A recently proposed (J. Am. Chem. Soc.
Costantino Zazza +2 more
wiley +1 more source
El Trimestre Económico, 2019 Antecedentes: La segunda generación de modelos de federalismo fiscal (SGFF) advierte que la dependencia fiscal puede incitar la pereza de los gobiernos locales y estancar la generación de ingresos propios; además, puede promover la corrupción y una menor
Alfonso Mendoza Velázquez
doaj +1 more source
Supplemental Figure 5 from First-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer
, 2020 PET detects PU-H71 retention by lymphoma. 62-year-old female with non-Hodgkin lymphoma. 124I-PU-H71 fusion PET/CT (left), CT (middle), and F-18 FDG fusion PET/CT (right) images show corresponding axial planes of chest.
Milan Grkovski (15026429) +22 more
core +1 more source
Economics: Journal Articles, 2019 This work examines in depth the hypotheses explaining the tax capacity of regional governments, also determining their tax effort and explanatory factors.
Zárate-Marco Anabel +1 more
doaj +1 more source
Reframing Alzheimer's disease as a complex adaptive system: More than an amyloid beta–tau connection
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.Abstract Alzheimer's disease (AD) is the leading cause of dementia, but simple models focusing on amyloid beta and tau only partially explain its variability and limited success in treatment. Evidence from systems biology, neuroimmunology, connectomics, and computational modeling supports viewing AD as a complex adaptive system, a multiscale network in
Maurizio Giorelli
wiley +1 more source
Economics and Culture, 2019 Research purpose. The purpose of this study was to determine the role of small and medium enterprises in the economy, as well as to study and evaluate the effectiveness of government support methods for small business entities (SMEs) using the example of
Verovska Ludmila, Zujeva Renate
doaj +1 more source
Attempts to Achieve Targeted Covalent Inhibition of Hsp90β
Chemical Biology &Drug Design, Volume 107, Issue 4, April 2026.Electrophilic warheads were incorporated into Hsp90β‐selective inhibitors to covalently modify Lys58, which occupies the solvent‐exposed region of the binding pocket. Although many inhibitors display nanomolar affinity towards Hsp90β over a 24‐h period, analyses to determine covalent bond formation with this residue were inconclusive.
Terin D'Amico +3 more
wiley +1 more source
Supplemental Figure 4 from First-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer
, 2020 PET detects subcentimeter PU-H71 retention by breast cancer metastases. 65-year-old female with stage IV breast cancer, off-treatment. 124I-PU-H71 PET (right), CT (left), and fusion PET/CT (middle) images show corresponding axial planes of chest ...
Milan Grkovski (15026429) +22 more
core +1 more source
The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities
MedComm, Volume 7, Issue 3, March 2026.Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou +5 more
wiley +1 more source