The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati +4 more
wiley +1 more source
Structural and mechanistic insights into the herpes simplex virus type 1 helicase-primase primosome. [PDF]
Wu Y +5 more
europepmc +1 more source
Deacetylase inhibitors CM‐444 and CM‐1758 enhance chemotherapy response in AML via ALOX5
British Journal of Haematology, EarlyView.
Naroa Gimenez‐Camino +7 more
wiley +1 more source
NCOA7 inhibits renal cancer progression by inducing autophagy and lipid metabolism through V-ATPase interaction. [PDF]
Wang J +7 more
europepmc +1 more source
<i>In silico</i> Analysis of <i>CHD4</i> Mutations Reveals Domain-Specific Impacts on Cardiovascular Disorders Among Patients With Rare Diseases. [PDF]
Novillo A +5 more
europepmc +1 more source
Small-Molecule Sarco/Endoplasmic Reticulum Ca<sup>2+</sup>-ATPase Activators Reverse Methylglyoxal-Induced Inhibition through Nonantioxidant Mechanisms. [PDF]
Cruz-Cortés C +4 more
europepmc +1 more source
Homology Modeling of Type-P5 ATPases from the Malaria Parasite: Insight into Their Functions and Evolution, and Implications About the Effect and Role of Intrinsically Disordered Protein Structure. [PDF]
Wiser MF.
europepmc +1 more source
Orange-Derived Extracellular Vesicles: Characterization and Therapeutic Applications in Normal and Diabetic Wound Healing in In Vivo Models. [PDF]
Gai C +16 more
europepmc +1 more source

