Results 101 to 110 of about 1,094,944 (319)

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Detection of Diffuse Hot Gas around the Young, Potential Superstar Cluster H72.97–69.39

open access: yesThe Astrophysical Journal
We present the first Chandra X-ray observations of H72.97–69.39, a highly embedded, potential superstar cluster in its infancy located in the star-forming complex N79 of the Large Magellanic Cloud. We detect particularly hard, diffuse X-ray emission that
Trinity L. Webb   +8 more
doaj   +1 more source

Properties of H II region populations in galaxies. I - The first-ranked H II regions

open access: yesThe Astrophysical Journal, 1988
H-alpha photometry of the brightest H II regions in 95 nearby spiral and irregular galaxies has been analyzed in order to study the dependence of the H II region populations on the properties of their parent galaxies. It is found that the brightest H II regions in Magellanic irregular galaxies are about 50 times brighter than those in early-type ...
openaire   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

ALMA-QUARKS: Few-thousand-year “Hatching out of the Egg:” The Supersonic Breakout of a Hypercompact H II Region from Its Parental Hot Core

open access: yesThe Astrophysical Journal
The kinematic evolution of hypercompact (HC) H ii regions around young high-mass stars remains poorly understood due to complex interactions with parental environs.
Siju Zhang   +21 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Investigating H II Regions in the Disk of NGC 7331 with the Circumgalactic Hα Spectrograph

open access: yesThe Astrophysical Journal
We investigate the ionized gas kinematics of H ii regions in the disk of NGC 7331 using integral field unit data collected with the Circumgalactic H α Spectrograph (CH α S).
Nazende ipek Kerkeser   +5 more
doaj   +1 more source

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