Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Site-directed Chemical Modification of Cysteine-scanning Mutants as to Transmembrane Segment II and Its Flanking Regions of the Tn10-encoded Metal-Tetracycline/H+ Antiporter Reveals a Transmembrane Water-filled Channel [PDF]
, 1998 Tomomi Kimura‐Someya +2 more
openalex +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Unveiling Physical Conditions and Star Formation Processes in the G47 Filamentary Cloud
The Astrophysical JournalWe present a multiwavelength study of the filamentary cloud G47 ( d ∼ 4.44 kpc), which hosts the mid-infrared bubbles N98, B1, and B2. The SMGPS 1.3 GHz continuum map detects ionized emission toward all the bubbles, marking the first detection of ionized
O. R. Jadhav +8 more
doaj +1 more source
Neutral hydrogen and star formation in irregular galaxies [PDF]
The Very Large Array and WSTR H I synthesis observations of seven irregular galaxies are presented. The total H I images of four Local Group dwarf irregular galaxies and three larger more distant irregular galaxies are constructed at the identical ...
Skillman, Evan D.
core +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Quantification of the Age Dependence of Mid-infrared Star Formation Rate Indicators
The Astrophysical JournalWe combine James Webb Space Telescope images of the nearby galaxy NGC 5194 in the hydrogen recombination line Pa α (1.8756 μ m) from the Cycle 1 program JWST-FEAST with 21 μ m dust continuum images from the Cycle 2 Treasury program JWGT to quantify the ...
Daniela Calzetti +35 more
doaj +1 more source
Infrared Space ObservatoryShort Wavelength Spectrometer Observations of H
, 2002 Joshua G. Nollenberg +3 more
openalex +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Masses, Star Formation Efficiencies, and Dynamical Evolution of 18,000 H ii Regions
The Astrophysical Journal LettersWe present measurements of the masses associated with ∼18,000 H ii regions across 19 nearby star-forming galaxies by combining data from JWST, Hubble Space Telescope, MUSE, Atacama Large Millimeter/submillimeter Array, Very Large Array, and MeerKAT ...
Debosmita Pathak +38 more
doaj +1 more source