Results 131 to 140 of about 1,094,944 (319)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Implications for Galactic Electron Density Structure from Pulsar Sightlines Intersecting H ii Regions

open access: yesThe Astrophysical Journal
Recent radio surveys have revealed pulsars with dispersion and scattering delays induced by ionized gas that are larger than the rest of the observed pulsar population, in some cases with electron column densities (or dispersion measures, DMs) larger ...
Stella Koch Ocker   +4 more
doaj   +1 more source

Expanding H II Region.

open access: yesThe Astrophysical Journal, 1955
Malcolm P. Savedoff, John Greene
openaire   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

LAMOST Medium-resolution Spectroscopic Survey of the Rosette Nebula

open access: yesThe Astronomical Journal
We report multifiber, medium-resolution spectroscopy of the Rosette Nebula with full spatial coverages, and present a table of the nebular parameters based on the spatially resolved measurements of emission lines.
Li-Yue Zhang   +6 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Unified Spectrospatial Forward Models: Spatially Continuous Maps of Weak Emission Lines in the Rosette Nebula with SDSS-V LVM

open access: yesThe Astrophysical Journal
Analyses of integral field unit data are typically performed on a per-spaxel basis, with each spectrum modelled independently. For low signal-to-noise ratio (S/N) features such as weak emission lines, estimating properties is difficult and imprecise ...
Thomas Hilder   +17 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Consistent Gas-phase C/O Abundances from UV and Optical Emission Lines: A Robust Scale for Chemical Evolution across Cosmic Time

open access: yesThe Astrophysical Journal
The carbon-to-oxygen (C/O) abundance ratio is a valuable tracer of star formation history, as C and O enrichment occurs on different timescales. However, measurements based on ultraviolet (UV) collisionally excited lines and those based on optical ...
Paige M. Kelly   +7 more
doaj   +1 more source

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