Results 141 to 150 of about 1,861,445 (361)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Quantification of the Age Dependence of Mid-infrared Star Formation Rate Indicators

The Astrophysical Journal
We combine James Webb Space Telescope images of the nearby galaxy NGC 5194 in the hydrogen recombination line Pa α (1.8756 μ m) from the Cycle 1 program JWST-FEAST with 21 μ m dust continuum images from the Cycle 2 Treasury program JWGT to quantify the ...
Daniela Calzetti, Robert C. Kennicutt, Angela Adamo, Karin Sandstrom, Daniel A. Dale, Bruce Elmegreen, John S. Gallagher, Benjamin Gregg, Varun Bajaj, Torsten Böker, Giacomo Bortolini, Martha Boyer, Matteo Correnti, Ilse De Looze, Bruce T. Draine, Ana Duarte-Cabral, Helena Faustino Vieira, Kathryn Grasha, L. K. Hunt, Kelsey E. Johnson, Ralf S. Klessen, Mark R. Krumholz, Thomas S.-Y. Lai, Drew Lapeer, Sean T. Linden, Matteo Messa, Göran Östlin, Alex Pedrini, Mònica Relaño, Elena Sabbi, Eva Schinnerer, Evan Skillman, Linda J. Smith, Monica Tosi, Fabian Walter, Tony D. Weinbeck   +35 more
doaj   +1 more source

Infrared Space ObservatoryShort Wavelength Spectrometer Observations of HiiRegions in NGC 6822 and I Zwicky 36: Sulfur Abundances and Temperature Fluctuations [PDF]

, 2002
Joshua G. Nollenberg, Evan D. Skillman, Donald R. Garnett, Harriet L. Dinerstein   +3 more
openalex   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Masses, Star Formation Efficiencies, and Dynamical Evolution of 18,000 H ii Regions

The Astrophysical Journal Letters
We present measurements of the masses associated with ∼18,​​​​​000 H ii regions across 19 nearby star-forming galaxies by combining data from JWST, Hubble Space Telescope, MUSE, Atacama Large Millimeter/submillimeter Array, Very Large Array, and MeerKAT ...
Debosmita Pathak, Adam K. Leroy, Ashley. T. Barnes, Todd A. Thompson, Laura A. Lopez, Karin M. Sandstrom, Jiayi Sun, Simon C. O. Glover, Ralf S. Klessen, Eric W. Koch, Kirsten L. Larson, Janice Lee, Sharon Meidt, Patricia Sanchez-Blazquez, Eva Schinnerer, Zein Bazzi, Francesco Belfiore, Médéric Boquien, Ryan Chown, Dario Colombo, Enrico Congiu, Oleg V. Egorov, Cosima Eibensteiner, Sushma Kurapati, Miguel Querejeta, Daniel A. Dale, Timo Kravtsov, Mansi Padave, D. J. Pisano, Erik Rosolowsky, Sumit K. Sarbadhicary, Thomas G. Williams, Remy Indebetouw, Hsi-An Pan, Leonardo Úbeda, Amirnezam Amiri, Frank Bigiel, Guillermo A. Blanc, Kathryn Grasha   +38 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Vacuum Ultraviolet Single Photon Ionization and Decomposition of 2-Aminopropionitrile in Astrophysical Objects

The Astrophysical Journal
The molecule 2-aminopropionitrile (2-APN; H _3 CCH(NH _2 )CN) is a chiral precursor of the amino acid alanine and could play an important role in the emergence of the homochirality of life.
Helgi Rafn Hrodmarsson, Martin Schwell, Nicolas Fray, Jean-Claude Guillemin, Majdi Hochlaf, Emilie-Laure Zins   +5 more
doaj   +1 more source

[Neii] Observations of Gas Motions in Compact and Ultracompact HiiRegions [PDF]

, 2008
Qing‐Feng Zhu, John H. Lacy, Daniel T. Jaffe, Matthew J. Richter, Thomas K. Greathouse   +4 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

H II regions and the abundance properties of spiral galaxies

, 1994
D. Zaritsky, R. Kennicutt, J. Huchra
semanticscholar   +1 more source