Results 151 to 160 of about 4,605,994 (345)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Quantification of the Age Dependence of Mid-infrared Star Formation Rate Indicators

The Astrophysical Journal
We combine James Webb Space Telescope images of the nearby galaxy NGC 5194 in the hydrogen recombination line Pa α (1.8756 μ m) from the Cycle 1 program JWST-FEAST with 21 μ m dust continuum images from the Cycle 2 Treasury program JWGT to quantify the ...
Daniela Calzetti, Robert C. Kennicutt, Angela Adamo, Karin Sandstrom, Daniel A. Dale, Bruce Elmegreen, John S. Gallagher, Benjamin Gregg, Varun Bajaj, Torsten Böker, Giacomo Bortolini, Martha Boyer, Matteo Correnti, Ilse De Looze, Bruce T. Draine, Ana Duarte-Cabral, Helena Faustino Vieira, Kathryn Grasha, L. K. Hunt, Kelsey E. Johnson, Ralf S. Klessen, Mark R. Krumholz, Thomas S.-Y. Lai, Drew Lapeer, Sean T. Linden, Matteo Messa, Göran Östlin, Alex Pedrini, Mònica Relaño, Elena Sabbi, Eva Schinnerer, Evan Skillman, Linda J. Smith, Monica Tosi, Fabian Walter, Tony D. Weinbeck   +35 more
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Implications for Galactic Electron Density Structure from Pulsar Sightlines Intersecting H ii Regions

The Astrophysical Journal
Recent radio surveys have revealed pulsars with dispersion and scattering delays induced by ionized gas that are larger than the rest of the observed pulsar population, in some cases with electron column densities (or dispersion measures, DMs) larger ...
Stella Koch Ocker, Loren D. Anderson, T. Joseph W. Lazio, James M. Cordes, Vikram Ravi   +4 more
doaj   +1 more source

The chemical composition of H ii regions in the outer Galaxy [PDF]

, 1996
J. M. Vı́lchez, C. Esteban
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Fundamental Parameters for Central Stars of 103 Infrared Bow Shock Nebulae

The Astrophysical Journal
Stellar bow shock nebulae are arcuate shock fronts formed by the interaction of radiation-driven stellar winds and the relative motion of the ambient interstellar material.
Nikhil Patten, Henry A. Kobulnicky, Matthew S. Povich, Angelica S. Whisnant, Sydney Andrews, Alexandra Boone, Srujan Dandu, Naomi Jones, S. Nick Justice, Dylan Hope, Alexander Larsen, Ryan McCrory, Julia Meredith, Maria Renee Meza, Alexandra C. Rosenthal, William Salazar, Alexander R. Sterling, Noshin Yesmin, Daniel A. Dale   +18 more
doaj   +1 more source

H II regions and the abundance properties of spiral galaxies

, 1994
D. Zaritsky, R. Kennicutt, J. Huchra
semanticscholar   +1 more source

Neutral hydrogen and star formation in irregular galaxies [PDF]

The Very Large Array and WSTR H I synthesis observations of seven irregular galaxies are presented. The total H I images of four Local Group dwarf irregular galaxies and three larger more distant irregular galaxies are constructed at the identical ...
Skillman, Evan D.
core   +1 more source