Results 151 to 160 of about 1,861,445 (361)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Implications for Galactic Electron Density Structure from Pulsar Sightlines Intersecting H ii Regions

The Astrophysical Journal
Recent radio surveys have revealed pulsars with dispersion and scattering delays induced by ionized gas that are larger than the rest of the observed pulsar population, in some cases with electron column densities (or dispersion measures, DMs) larger ...
Stella Koch Ocker, Loren D. Anderson, T. Joseph W. Lazio, James M. Cordes, Vikram Ravi   +4 more
doaj   +1 more source

H II regions in peculiar galaxies

The Astrophysical Journal, 1975
A survey of 32 galaxies, either classified as peculiar or having peculiar distributions of H ii regions, is presented in order to ascertain the range of the peculiarities and the degree to which they are similar. Ten different types are recognized, several of which are interrelated.
openaire   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

LAMOST Medium-resolution Spectroscopic Survey of the Rosette Nebula

The Astronomical Journal
We report multifiber, medium-resolution spectroscopy of the Rosette Nebula with full spatial coverages, and present a table of the nebular parameters based on the spatially resolved measurements of emission lines.
Li-Yue Zhang, Chao-Jian Wu, Xuan Fang, Wei Zhang, Juan-Juan Ren, Jian-Jun Chen, Hong Wu   +6 more
doaj   +1 more source

Theoretical models for H II regions. II - The extragalactic H II region abundance sequence

The Astrophysical Journal, 1986
M. A. Dopita, I. N. Evans
openaire   +1 more source

Expansion of Ultra-Compact H II Regions [PDF]

, 1987
J. M. Moran, M. J. Reid, B. Sams
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Consistent Gas-phase C/O Abundances from UV and Optical Emission Lines: A Robust Scale for Chemical Evolution across Cosmic Time

The Astrophysical Journal
The carbon-to-oxygen (C/O) abundance ratio is a valuable tracer of star formation history, as C and O enrichment occurs on different timescales. However, measurements based on ultraviolet (UV) collisionally excited lines and those based on optical ...
Paige M. Kelly, Tucker Jones, Yuguang Chen, Ryan L. Sanders, Danielle A. Berg, Peter Senchyna, Fabio Bresolin, Daniel Stark   +7 more
doaj   +1 more source

Massive Star Formation in Luminous Infrared Galaxies: Giant H [CSC]ii[/CSC] Regions and Their Relation to Super–Star Clusters [PDF]

, 2002
A. Alonso‐Herrero, G. H. Rieke, Marcia Rieke, N. Z. Scoville   +3 more
openalex   +1 more source