Results 1 to 10 of about 24,976 (191)

Paraspinal extramedullary haematopoiesis in a patient with sickle cell disease: a rare clinical presentation [PDF]

European Journal of Case Reports in Internal Medicine
Background: Extramedullary haematopoiesis refers to the formation of blood cells outside the bone marrow, typically as a compensatory response to chronic anaemia or bone marrow failure.
Anurag Raje, Gowtham Siddi, Amita D'Souza, Amit Correa   +3 more
doaj   +2 more sources

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

Nature Communications, 2016
Clonal haematopoiesis has been thought to occur in less than 10% of individuals younger than 70 years old. Here, the authors use an error corrected next-generation sequencing method to find clonal haematopoiesis in the peripheral blood of 19 of 20 ...
Andrew L. Young, Grant A. Challen, Brenda M. Birmann, Todd E. Druley   +3 more
doaj   +2 more sources

Irradiation Haematopoiesis Recovery Orchestrated by IL-12/IL-12Rβ1/TYK2/STAT3-Initiated Osteogenic Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells [PDF]

Frontiers in Cell and Developmental Biology, 2021
PurposeRepairing the irradiation-induced osteogenic differentiation injury of bone marrow mesenchymal stem cells (BM-MSCs) is beneficial to recovering haematopoiesis injury in radiotherapy; however, its mechanism is elusive.
Fengjie Li, Rong Zhang, Changpeng Hu, Qian Ran, Yang Xiang, Lixin Xiang, Li Chen, Yang Yang, Shengwen Calvin Li, Gang Zhang, Zhongjun Li   +10 more
doaj   +2 more sources

Faster postnatal decline in hepatic erythropoiesis than granulopoiesis in human newborns [PDF]

Frontiers in Pediatrics
BackgroundDuring human foetal development, the liver is the primary site of blood cell production, but this activity declines in the third trimester and postnatally as haematopoiesis shifts to bone marrow.
Petra Janovska, Kristina Bardova, Zuzana Prouzova, Zuzana Prouzova, Ilaria Irodenko, Tatyana Kobets, Eliska Haasova, Eliska Haasova, Lenka Steiner Mrazova, Lenka Steiner Mrazova, Viktor Stranecky, Stanislav Kmoch, Martin Rossmeisl, Petr Zouhar, Jan Kopecky   +14 more
doaj   +2 more sources

Haematopoiesis in Zebrafish (Danio Rerio)

Frontiers in Immunology, 2022
Haematopoiesis in fish and mammals is a complex process, and many aspects regarding its model and the differentiation of haematopoietic stem cells (HSCs) still remain enigmatic despite advanced studies.
Michał Stosik, Beata Tokarz-Deptuła, Wiesław Deptuła   +2 more
doaj   +1 more source

Optimal experimental design for mathematical models of haematopoiesis. [PDF]

, 2021
The haematopoietic system has a highly regulated and complex structure in which cells are organized to successfully create and maintain new blood cells.
Iniguez, Abdon, Jena, Nilamani, Lander, Arthur D, Liu, Zhong-Ying, Lomeli, Luis Martinez, Lowengrub, John S, Minin, Vladimir N, Shahbaba, Babak, Tata, Prasanthi, Van Etten, Richard   +9 more
core   +1 more source

New light shed on the early evolution of limb-bone growth plate and bone marrow

eLife, 2021
The production of blood cells (haematopoiesis) occurs in the limb bones of most tetrapods but is absent in the fin bones of ray-finned fish. When did long bones start producing blood cells?
Jordi Estefa, Paul Tafforeau, Alice M Clement, Jozef Klembara, Grzegorz Niedźwiedzki, Camille Berruyer, Sophie Sanchez   +6 more
doaj   +1 more source

Retinoic acid receptor regulation of decision-making for cell differentiation

Frontiers in Cell and Developmental Biology, 2023
All-trans retinoic acid (ATRA) activation of retinoic acid receptors (RARs) is crucial to an organism’s proper development as established by findings for mouse foetuses from dams fed a vitamin A-deficient diet.
Geoffrey Brown
doaj   +1 more source

Zoledronic acid inhibits the growth of leukemic MLL-AF9 transformed hematopoietic cells

Heliyon, 2020
A leukemic in vitro model produced by transducing Cord Blood derived-hematopoietic CD34+ cells with the MLL-AF9 translocation resulting in the oncogenic fusion protein, is used to assess for sensitivity to Zoledronic acid.
Emanuela Chiarella, Bruna Codispoti, Annamaria Aloisio, Emanuela G. Cosentino, Stefania Scicchitano, Ylenia Montalcini, Daniela Lico, Giovanni Morrone, Maria Mesuraca, Heather M. Bond   +9 more
doaj   +1 more source

Searching for the Origin and the Differentiation of Haemocytes before and after Larval Settlement of the Colonial Ascidian Botryllus schlosseri: An Ultrastructural Viewpoint

Journal of Marine Science and Engineering, 2022
The colonial ascidian Botryllus schlosseri possesses an innate immunity, which plays fundamental roles in its survival, adaptability, worldwide spread and ecological success.
Francesca Cima
doaj   +1 more source