Results 1 to 10 of about 22,731 (338)

GATA2 mitotic bookmarking is required for definitive haematopoiesis [PDF]

Nature Communications, 2023
In mitosis, most transcription factors detach from chromatin, but some are retained and bookmark genomic sites. Mitotic bookmarking has been implicated in lineage inheritance, pluripotency and reprogramming.
Rita Silvério-Alves, Ilia Kurochkin, Anna Rydström, Camila Vazquez Echegaray, Jakob Haider, Matthew Nicholls, Christina Rode, Louise Thelaus, Aida Yifter Lindgren, Alexandra Gabriela Ferreira, Rafael Brandão, Jonas Larsson, Marella F. T. R. de Bruijn, Javier Martin-Gonzalez, Carlos-Filipe Pereira   +14 more
doaj   +3 more sources

Extramedullary haematopoiesis in the kidney [PDF]

Clinical Kidney Journal, 2012
Extramedullary haematopoiesis (EMH) is the development of haematopoietic tissue outside the bone marrow and it most often occurs in the liver and spleen. Renal EMH is quite rare and there are very few case reports concerning the kidney. We describe two cases of 'renal histologically documented EMH' and, in particular, in the second of these two, the ...
Davide Ricci, Marcora Mandreoli, Massimo Valentino, Elena Sabattini, Angela Santoro   +4 more
openalex   +4 more sources

Haematopoiesis in Zebrafish (Danio Rerio)

Frontiers in Immunology, 2022
Haematopoiesis in fish and mammals is a complex process, and many aspects regarding its model and the differentiation of haematopoietic stem cells (HSCs) still remain enigmatic despite advanced studies.
Michał Stosik, Beata Tokarz-Deptuła, Wiesław Deptuła   +2 more
doaj   +3 more sources

Updates on Old and Weary Haematopoiesis [PDF]

International Journal of Molecular Sciences, 2018
Blood formation, or haematopoiesis, originates from haematopoietic stem cells (HSCs), whose functions and maintenance are regulated in both cell- and cell non-autonomous ways. The surroundings of HSCs in the bone marrow create a specific niche or microenvironment where HSCs nest that allows them to retain their unique characteristics and respond ...
Joanna Konieczny, Lorena Arranz
openaire   +8 more sources

The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain [PDF]

Royal Society Open Science, 2020
Chromatin remodelling and transcription factors play important roles in lineage commitment and development through control of gene expression. Activation of selected lineage-specific genes and repression of alternative lineage-affiliated genes result in ...
Dimple Karia, Robert C. G. Gilbert, Antonio J. Biasutto, Catherine Porcher, Erika J. Mancini   +4 more
doaj   +4 more sources

MicroRNAs as Haematopoiesis Regulators

Advances in Hematology, 2013
The production of different types of blood cells including their formation, development, and differentiation is collectively known as haematopoiesis.
Ram Babu Undi, Ravinder Kandi, Ravi Kumar Gutti   +2 more
doaj   +4 more sources

Adhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid Leukaemia [PDF]

Frontiers in Immunology, 2021
In the bone marrow (BM) of adult mammals, haematopoietic stem cells (HSCs) are retained in micro-anatomical structures by adhesion molecules that regulate HSC quiescence, proliferation and commitment.
Julien M. P. Grenier, Céline Testut, Cyril Fauriat, Stéphane J.C. Mancini, Michel Aurrand‐Lions   +4 more
openalex   +3 more sources

HIV and haematopoiesis

South African Medical Journal, 2019
Human immunodeficiency virus (HIV) infection not only leads to a compromised immune system, but also disrupts normal haematopoiesis, resulting in the frequent manifestation of cytopenias (anaemia, thrombocytopenia and neutropenia). Although there is a definite association between the severity of cytopenia and HIV disease stage, this relationship is not
Chrisna Durandt, J Potgieter, Juanita Mellet, Candice Lee Herd, R Khoosal, Jan G. Nel, Theresa M. Rossouw, Michael S. Pepper   +7 more
openalex   +5 more sources

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

Nature Communications, 2016
Clonal haematopoiesis has been thought to occur in less than 10% of individuals younger than 70 years old. Here, the authors use an error corrected next-generation sequencing method to find clonal haematopoiesis in the peripheral blood of 19 of 20 ...
Andrew L. Young, Grant A. Challen, Brenda M. Birmann, Todd E. Druley   +3 more
openalex   +2 more sources

A newly identified gene Ahed plays essential roles in murine haematopoiesis [PDF]

Nature Communications
The development of haematopoiesis involves the coordinated action of numerous genes, some of which are implicated in haematological malignancies. However, the biological function of many genes remains elusive and unknown functional genes are likely to ...
Ritsuko Nakai, Takafumi Yokota, Masahiro Tokunaga, Mikiro Takaishi, Tomomasa Yokomizo, Takao Sudo, Henyun Shi, Yoshiaki Yasumizu, Daisuke Okuzaki, Chikara Kokubu, Sachiyo Tanaka, Katsuyoshi Takaoka, Ayako Yamanishi, Junko Yoshida, Hitomi Watanabe, Gen Kondoh, Kyoji Horie, Naoki Hosen, Shigetoshi Sano, Junji Takeda   +19 more
doaj   +2 more sources