Haematopoiesis in Zebrafish (Danio Rerio)
Frontiers in Immunology, 2022 Haematopoiesis in fish and mammals is a complex process, and many aspects regarding its model and the differentiation of haematopoietic stem cells (HSCs) still remain enigmatic despite advanced studies.
Michał Stosik +2 more
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Optimal experimental design for mathematical models of haematopoiesis. [PDF]
, 2021 The haematopoietic system has a highly regulated and complex structure in which cells are organized to successfully create and maintain new blood cells.
Iniguez, Abdon +9 more
core +1 more source
New light shed on the early evolution of limb-bone growth plate and bone marrow
eLife, 2021 The production of blood cells (haematopoiesis) occurs in the limb bones of most tetrapods but is absent in the fin bones of ray-finned fish. When did long bones start producing blood cells?
Jordi Estefa +6 more
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Retinoic acid receptor regulation of decision-making for cell differentiation
Frontiers in Cell and Developmental Biology, 2023 All-trans retinoic acid (ATRA) activation of retinoic acid receptors (RARs) is crucial to an organism’s proper development as established by findings for mouse foetuses from dams fed a vitamin A-deficient diet.
Geoffrey Brown
doaj +1 more source
Journal of Marine Science and Engineering, 2022 The colonial ascidian Botryllus schlosseri possesses an innate immunity, which plays fundamental roles in its survival, adaptability, worldwide spread and ecological success.
Francesca Cima
doaj +1 more source
Zoledronic acid inhibits the growth of leukemic MLL-AF9 transformed hematopoietic cells
Heliyon, 2020 A leukemic in vitro model produced by transducing Cord Blood derived-hematopoietic CD34+ cells with the MLL-AF9 translocation resulting in the oncogenic fusion protein, is used to assess for sensitivity to Zoledronic acid.
Emanuela Chiarella +9 more
doaj +1 more source
The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain [PDF]
, 2020 Chromatin remodelling and transcription factors play important roles in lineage commitment and development through control of gene expression. Activation of selected lineage-specific genes and repression of alternative lineage-affiliated genes results in
Biasutto, Antonio J +4 more
core +1 more source
GATA2 mitotic bookmarking is required for definitive haematopoiesis
Nature Communications, 2023 In mitosis, most transcription factors detach from chromatin, but some are retained and bookmark genomic sites. Mitotic bookmarking has been implicated in lineage inheritance, pluripotency and reprogramming.
Rita Silvério-Alves +14 more
doaj +1 more source
Zebrafish Caudal Haematopoietic Embryonic Stromal Tissue (CHEST) Cells Support Haematopoiesis. [PDF]
, 2017 Haematopoiesis is an essential process in early vertebrate development that occurs in different distinct spatial locations in the embryo that shift over time.
Aggio, Julian +6 more
core +1 more source
Monocytes, Macrophages, and Metabolic Disease in Atherosclerosis
Frontiers in Pharmacology, 2019 Atherosclerotic cardiovascular disease (CVD) is a lipid-driven chronic inflammatory disease, in which macrophages are responsible for taking up these lipids and driving disease progression.
Michelle C. Flynn +4 more
doaj +1 more source