GATA2 mitotic bookmarking is required for definitive haematopoiesis [PDF]
Nature Communications, 2023 In mitosis, most transcription factors detach from chromatin, but some are retained and bookmark genomic sites. Mitotic bookmarking has been implicated in lineage inheritance, pluripotency and reprogramming.
Brandão, Rafael +14 more
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The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain [PDF]
Royal Society Open Science, 2020 Chromatin remodelling and transcription factors play important roles in lineage commitment and development through control of gene expression. Activation of selected lineage-specific genes and repression of alternative lineage-affiliated genes results in
Biasutto, Antonio J +4 more
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Optimal experimental design for mathematical models of haematopoiesis. [PDF]
, 2021 The haematopoietic system has a highly regulated and complex structure in which cells are organized to successfully create and maintain new blood cells.
Iniguez, Abdon +9 more
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The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis [PDF]
, 2021 Clonal haematopoiesis, which is highly prevalent in older individuals, arises from somatic mutations that endow a proliferative advantage to haematopoietic cells.
Abramowicz, Sandra +25 more
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Zebrafish Caudal Haematopoietic Embryonic Stromal Tissue (CHEST) Cells Support Haematopoiesis. [PDF]
, 2017 Haematopoiesis is an essential process in early vertebrate development that occurs in different distinct spatial locations in the embryo that shift over time.
Aggio, Julian +6 more
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Mechanisms controlling anaemia in Trypanosoma congolense infected mice. [PDF]
, 2009 Trypanosoma congolense are extracellular protozoan parasites of the blood stream of artiodactyls and are one of the main constraints on cattle production in Africa.
A Kobayashi +74 more
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CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development [PDF]
, 2011 The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation and ...
Abramoff +66 more
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Dysregulation of NIPBL leads to impaired RUNX1 expression and hematopoietic defects [PDF]
, 2020 The transcription factor RUNX1, a pivotal regulator of HSCs and haematopoiesis, is a frequent target of chromosomal translocations, point mutations or altered gene/protein dosage.
A. Biondi +14 more
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Haemogenic endocardium contributes to transient definitive haematopoiesis. [PDF]
, 2013 Haematopoietic cells arise from spatiotemporally restricted domains in the developing embryo. Although studies of non-mammalian animal and in vitro embryonic stem cell models suggest a close relationship among cardiac, endocardial and haematopoietic ...
Arshi, Armin +14 more
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Preliminary investigation of the effects of long-term dietary intake of genistein and daidzein on hepatic histopathology and biochemistry in domestic cats (Felis catus) [PDF]
, 2012 Dietary isoflavones have been hypothesised to play a role in hepatic veno-occlusive disease in captive exotic felids, although empirical evidence is lacking. This study aimed to investigate the effect of long-term (>1 year) dietary genistein and daidzein
Cave, NJ +4 more
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