Results 1 to 10 of about 28,724 (382)

Haematopoiesis in Zebrafish (Danio Rerio)

Frontiers in Immunology, 2022
Haematopoiesis in fish and mammals is a complex process, and many aspects regarding its model and the differentiation of haematopoietic stem cells (HSCs) still remain enigmatic despite advanced studies.
Michał Stosik, Beata Tokarz-Deptuła, Wiesław Deptuła   +2 more
doaj   +4 more sources

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

Nature Communications, 2016
Clonal haematopoiesis has been thought to occur in less than 10% of individuals younger than 70 years old. Here, the authors use an error corrected next-generation sequencing method to find clonal haematopoiesis in the peripheral blood of 19 of 20 ...
Andrew L. Young, Grant A. Challen, Brenda M. Birmann, Todd E. Druley   +3 more
doaj   +3 more sources

Colchicine prevents accelerated atherosclerosis in TET2-mutant clonal haematopoiesis. [PDF]

Eur Heart J
Background and Aims Somatic mutations in the TET2 gene that lead to clonal haematopoiesis (CH) are associated with accelerated atherosclerosis development in mice and a higher risk of atherosclerotic disease in humans. Mechanistically, these observations
Zuriaga MA, Yu Z, Matesanz N, Truong B, Ramos-Neble BL, Asensio-López MC, Uddin MM, Nakao T, Niroula A, Zorita V, Amorós-Pérez M, Moro R, Ebert BL, Honigberg MC, Pascual-Figal D, Natarajan P, Fuster JJ.   +16 more
europepmc   +2 more sources

Adhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid Leukaemia [PDF]

Frontiers in Immunology, 2021
In the bone marrow (BM) of adult mammals, haematopoietic stem cells (HSCs) are retained in micro-anatomical structures by adhesion molecules that regulate HSC quiescence, proliferation and commitment.
Julien M. P. Grenier, Céline Testut, Cyril Fauriat, Stéphane J. C. Mancini, Michel Aurrand-Lions   +4 more
doaj   +2 more sources

The Ribosome Biogenesis Protein Nol9 Is Essential for Definitive Hematopoiesis and Pancreas Morphogenesis in Zebrafish. [PDF]

, 2015
Ribosome biogenesis is a ubiquitous and essential process in cells. Defects in ribosome biogenesis and function result in a group of human disorders, collectively known as ribosomopathies.
Barroso, Inês, Bielczyk-Maczyńska, Ewa, Cvejic, Ana, Fernández-Pevida, Antonio, Ferreira, Lauren, Fleischmann, Tobias, Harvey, Steven A, Lam Hung, Laure, Stemple, Derek L, Wali, Neha, Warren, Alan J, Weis, Félix   +11 more
core   +10 more sources

Faster postnatal decline in hepatic erythropoiesis than granulopoiesis in human newborns [PDF]

Frontiers in Pediatrics
BackgroundDuring human foetal development, the liver is the primary site of blood cell production, but this activity declines in the third trimester and postnatally as haematopoiesis shifts to bone marrow.
Petra Janovska, Kristina Bardova, Zuzana Prouzova, Zuzana Prouzova, Ilaria Irodenko, Tatyana Kobets, Eliska Haasova, Eliska Haasova, Lenka Steiner Mrazova, Lenka Steiner Mrazova, Viktor Stranecky, Stanislav Kmoch, Martin Rossmeisl, Petr Zouhar, Jan Kopecky   +14 more
doaj   +2 more sources

Clonal dynamics of haematopoiesis across the human lifespan

Nature, 2021
Age-related change in human haematopoiesis causes reduced regenerative capacity1, cytopenias2, immune dysfunction3 and increased risk of blood cancer4–6, but the reason for such abrupt functional decline after 70 years of age remains unclear.
E. Mitchell, M. Spencer Chapman, N. Williams, K. Dawson, N. Mende, Emily F. Calderbank, Hyunchul Jung, T. Mitchell, Tim H. H. Coorens, D. Spencer, Heather E. Machado, H. Lee-Six, M. Davies, Daniel Hayler, M. Fabre, Krishnaa Mahbubani, F. Abascal, A. Cagan, G. Vassiliou, J. Baxter, I. Martincorena, M. Stratton, D. Kent, K. Chatterjee, K. Parsy, A. Green, J. Nangalia, E. Laurenti, P. Campbell   +28 more
semanticscholar   +1 more source

New light shed on the early evolution of limb-bone growth plate and bone marrow

eLife, 2021
The production of blood cells (haematopoiesis) occurs in the limb bones of most tetrapods but is absent in the fin bones of ray-finned fish. When did long bones start producing blood cells?
Jordi Estefa, Paul Tafforeau, Alice M Clement, Jozef Klembara, Grzegorz Niedźwiedzki, Camille Berruyer, Sophie Sanchez   +6 more
doaj   +1 more source

Common and rare variant associations with clonal haematopoiesis phenotypes

Nature, 2022
Clonal haematopoiesis involves the expansion of certain blood cell lineages and has been associated with ageing and adverse health outcomes1–5. Here we use exome sequence data on 628,388 individuals to identify 40,208 carriers of clonal haematopoiesis of
M. D. Kessler, A. Damask, S. O’Keeffe, N. Banerjee, Dadong Li, Kyoko Watanabe, Anthony Marketta, Michael Van Meter, S. Semrau, J. Horowitz, Jing Tang, J. Kosmicki, V. Rajagopal, Yuxin Zou, Y. Houvras, Arkopravo Ghosh, Christopher E. Gillies, J. Mbatchou, Ryan R. White, N. Verweij, J. Bovijn, N. Parikshak, M. LeBlanc, Marcus Jones, D. J. Glass, L. Lotta, M. Cantor, G. Atwal, A. Locke, M. Ferreira, R. Deering, C. Paulding, A. Shuldiner, G. Thurston, A. Ferrando, W. Salerno, J. Reid, J. Overton, J. Marchini, H. Kang, A. Baras, G. Abecasis, E. Jorgenson   +42 more
semanticscholar   +1 more source

Optimal experimental design for mathematical models of haematopoiesis. [PDF]

, 2021
The haematopoietic system has a highly regulated and complex structure in which cells are organized to successfully create and maintain new blood cells.
Iniguez, Abdon, Jena, Nilamani, Lander, Arthur D, Liu, Zhong-Ying, Lomeli, Luis Martinez, Lowengrub, John S, Minin, Vladimir N, Shahbaba, Babak, Tata, Prasanthi, Van Etten, Richard   +9 more
core   +1 more source