Mechanisms of fate decision and lineage commitment during haematopoiesis. [PDF]
, 2015 Blood stem cells need to both perpetuate themselves (self-renew) and differentiate into all mature blood cells to maintain blood formation throughout life.
Ana Cvejic, Bendall SC, Sousa Abreu R
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The role of the CCN family of proteins in blood cancers [PDF]
, 2016 Haematopoiesis is the term used to describe the production of blood cells. This is a tightly regulated hierarchical system in which mature circulating blood cells develop from a small population of haematopoietic stem (HSC) and progenitor cells within ...
Crawford, Lisa Judith +1 more
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Identification of stromal cells in spleen which support myelopoiesis [PDF]
, 2019 Stromal cells in spleen organize tissue into red pulp, white pulp and marginal zone, and also interact with hematopoietic cells to regulate immune responses.
Lim, Hong, O'Neill, Helen C
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RUNX1 Reshapes the Epigenetic Landscape at the Onset of Haematopoiesis [PDF]
, 2012 Cell fate decisions during haematopoiesis are governed by lineage-specific transcription factors, such as RUNX1, SCL/TAL1, FLI1 and C/EBP family members. To gain insight into how these transcription factors regulate the activation of haematopoietic genes
Assi, Salam A +15 more
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ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia [PDF]
, 2017 Additional sex combs-like (ASXL) proteins are mammalian homologues of additional sex combs (Asx), a regulator of trithorax and polycomb function in Drosophila.
A Balasubramani +67 more
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Identification of genes involved in leukaemia and differentiation induced by activated mutants of the GM-CSF receptor β subunit. [PDF]
, 2005 Interleukin (IL)-3, IL-5 and granulocyte-macrophage-colony-stimulating factor (GM-CSF) are cytokines that affect the growth, survival and differentiation of many cells within the haematopoietic system.
Reynolds, Brenton James
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Targeting quiescent leukemic stem cells using second generation autophagy inhibitors [PDF]
, 2019 In chronic myeloid leukemia (CML), tyrosine kinase inhibitor (TKI) treatment induces autophagy that promotes survival and TKI-resistance in leukemic stem cells (LSCs).
A Hamilton +42 more
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Control of globin gene expression by Kruppel-like factors [PDF]
, 2014 Kruppel-like factors (KLFs) are a family of seventeen proteins designated KLF1 to KLF17. KLFs are transcriptional factors that bind GC-rich sequences such as CACCC elements. The DNA binds to KLFs via three carboxyl-terminal Cys-2/His-2 zinc fingers. KLFs
Borg, Joseph, Grech, Laura
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The bone marrow microenvironment – Home of the leukemic blasts [PDF]
, 2017 Acute Myeloid Leukaemia (AML) is a genetically, biologically and clinically heterogeneous set of diseases, which are characterised by an increased growth of abnormal myeloid progenitor cells within the bone marrow (BM).
Bowles, Kristian M +3 more
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Tolerance and safety evaluation of N, N-dimethylglycine, a naturally occurring organic compound, as a feed additive in broiler diets [PDF]
, 2009 N, N-dimethylglycine (DMG) is a tertiary amino acid that naturally occurs as an intermediate metabolite in choline-to-glycine metabolism. The objective of the present trial was to evaluate tolerance, safety and bioaccumulation of dietary DMG in broilers ...
Kalmar, I.D. +5 more
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