Results 11 to 20 of about 28,636 (337)
Colchicine prevents accelerated atherosclerosis in TET2-mutant clonal haematopoiesis. [PDF]
Eur Heart JBackground and Aims Somatic mutations in the TET2 gene that lead to clonal haematopoiesis (CH) are associated with accelerated atherosclerosis development in mice and a higher risk of atherosclerotic disease in humans. Mechanistically, these observations
Zuriaga MA +16 more
europepmc +2 more sources
Germline risk of clonal haematopoiesis [PDF]
Nature Reviews Genetics, 2021 Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with somatic mutations that is associated with an increased risk of haematological malignancies, cardiovascular disease and all-cause mortality.
A. Silver, A. Bick, M. Savona
semanticscholar +3 more sources
Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults
Nature Communications, 2016 Clonal haematopoiesis is thought to be a rare condition that increases in frequency with age and predisposes individuals to haematological malignancy. Recent studies, utilizing next-generation sequencing (NGS), observed haematopoietic clones in 10% of 70-
Andrew L. Young +3 more
openalex +2 more sources
Haematopoiesis in Zebrafish (Danio Rerio)
Frontiers in Immunology, 2022 Haematopoiesis in fish and mammals is a complex process, and many aspects regarding its model and the differentiation of haematopoietic stem cells (HSCs) still remain enigmatic despite advanced studies.
Michał Stosik +2 more
semanticscholar +4 more sources
Extramedullary haematopoiesis in the kidney [PDF]
Clinical Kidney Journal, 2012 Extramedullary haematopoiesis (EMH) is the development of haematopoietic tissue outside the bone marrow and it most often occurs in the liver and spleen. Renal EMH is quite rare and there are very few case reports concerning the kidney. We describe two cases of 'renal histologically documented EMH' and, in particular, in the second of these two, the ...
Davide Ricci +4 more
openalex +4 more sources
South African Medical Journal, 2019 Human immunodeficiency virus (HIV) infection not only leads to a compromised immune system, but also disrupts normal haematopoiesis, resulting in the frequent manifestation of cytopenias (anaemia, thrombocytopenia and neutropenia). Although there is a definite association between the severity of cytopenia and HIV disease stage, this relationship is not
Chrisna Durandt +7 more
openalex +5 more sources
Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target. [PDF]
Nat Rev CardiolSchuermans A, Honigberg MC.
europepmc +2 more sources
Optimal experimental design for mathematical models of haematopoiesis. [PDF]
, 2021 The haematopoietic system has a highly regulated and complex structure in which cells are organized to successfully create and maintain new blood cells.
Iniguez, Abdon +9 more
core +1 more source
Clonal dynamics of haematopoiesis across the human lifespan
Nature, 2021 Age-related change in human haematopoiesis causes reduced regenerative capacity1, cytopenias2, immune dysfunction3 and increased risk of blood cancer4–6, but the reason for such abrupt functional decline after 70 years of age remains unclear.
E. Mitchell +28 more
semanticscholar +1 more source
Heterochromatin and Polycomb as regulators of haematopoiesis [PDF]
Biochemical Society Transactions, 2021 Haematopoiesis is the process by which multipotent haematopoietic stem cells are transformed into each and every type of terminally differentiated blood cell. Epigenetic silencing is critical for this process by regulating the transcription of cell-cycle genes critical for self-renewal and differentiation, as well as restricting alternative fate genes ...
Christine R. Keenan, Christine R. Keenan
openaire +3 more sources