Results 11 to 20 of about 22,731 (338)
Prognostic and therapeutic implications of TP53 expression in chronic myelomonocytic leukemia [PDF]
Blood Cancer JournalYu-Hung Wang +9 more
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Heterochromatin and Polycomb as regulators of haematopoiesis [PDF]
Biochemical Society Transactions, 2021 Haematopoiesis is the process by which multipotent haematopoietic stem cells are transformed into each and every type of terminally differentiated blood cell. Epigenetic silencing is critical for this process by regulating the transcription of cell-cycle genes critical for self-renewal and differentiation, as well as restricting alternative fate genes ...
Christine R. Keenan, Christine R. Keenan
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New light shed on the early evolution of limb-bone growth plate and bone marrow
eLife, 2021 The production of blood cells (haematopoiesis) occurs in the limb bones of most tetrapods but is absent in the fin bones of ray-finned fish. When did long bones start producing blood cells?
Jordi Estefa +6 more
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Journal of Marine Science and Engineering, 2022 The colonial ascidian Botryllus schlosseri possesses an innate immunity, which plays fundamental roles in its survival, adaptability, worldwide spread and ecological success.
Francesca Cima
doaj +1 more source
Retinoic acid receptor regulation of decision-making for cell differentiation
Frontiers in Cell and Developmental Biology, 2023 All-trans retinoic acid (ATRA) activation of retinoic acid receptors (RARs) is crucial to an organism’s proper development as established by findings for mouse foetuses from dams fed a vitamin A-deficient diet.
Geoffrey Brown
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Pulmonary extramedullary haematopoiesis [PDF]
Case Reports, 2011 A 72-year-old Caucasian lady with myeloproliferative disorder was admitted for evaluation of progressive dyspnoea, weight loss, fatigue and mild hypoxia. A diffuse ground glass opacity was seen on CT pulmonary angiogram. Differential diagnoses included heart failure, infection, progression of myeloproliferative disorder with extramedullary ...
Stephen Fanning +4 more
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Optimal experimental design for mathematical models of haematopoiesis. [PDF]
, 2021 The haematopoietic system has a highly regulated and complex structure in which cells are organized to successfully create and maintain new blood cells.
Iniguez, Abdon +9 more
core +1 more source
Germline risk of clonal haematopoiesis [PDF]
Nature Reviews Genetics, 2021 Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with somatic mutations that is associated with an increased risk of haematological malignancies, cardiovascular disease and all-cause mortality. CH may be caused by point mutations in genes associated with myeloid neoplasms, chromosomal copy number changes and loss of ...
Alexander J. Silver +2 more
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The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis [PDF]
, 2021 Clonal haematopoiesis, which is highly prevalent in older individuals, arises from somatic mutations that endow a proliferative advantage to haematopoietic cells.
Abramowicz, Sandra +25 more
core +1 more source
The MLL/SET family and haematopoiesis [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2020 As demonstrated through early work in Drosophila, members of the MLL/SET family play essential roles during embryonic development through their participation in large protein complexes that are central to epigenetic regulation of gene expression. One of its members, MLL1, has additionally received a lot of attention as it is a potent oncogenic driver ...
Antunes, Eric, Ottersbach, Katrin
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