Results 11 to 20 of about 16,847 (244)

In vitro differentiation of human embryonic stem cells to hemogenic endothelium and blood progenitors via embryoid body formation

STAR Protocols, 2021
Summary: Little is known about the emergence of blood progenitors during human embryogenesis due to ethical reasons and restricted embryo access. The use of human embryonic stem cells (hESCs) as a model system offers unique opportunities to dissect human
Eva Garcia-Alegria, Bethany Potts, Sara Menegatti, Valerie Kouskoff   +3 more
doaj   +1 more source

Consequences of HIV infection in the bone marrow niche

Frontiers in Immunology, 2023
Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV infection contributes to haematological abnormalities observed in HIV patients.
Candice Lee Herd, Juanita Mellet, Tsungai Mashingaidze, Chrisna Durandt, Michael Sean Pepper   +4 more
doaj   +1 more source

Haemogenic endocardium contributes to transient definitive haematopoiesis. [PDF]

, 2013
Haematopoietic cells arise from spatiotemporally restricted domains in the developing embryo. Although studies of non-mammalian animal and in vitro embryonic stem cell models suggest a close relationship among cardiac, endocardial and haematopoietic ...
Arshi, Armin, Conway, Simon J., Harmon, Andrew W., Harvey, Richard P., Liu, Xiaoqian, Mikkola, Hanna K. A., Nakano, Atsushi, Nakano, Haruko, Nakano, Haruko, Nakashima, Yasuhiro, Pashmforoush, Mohammad, Sasidharan, Rajkumar, Schwartz, Robert J., Shin, Jae-Ho, van Handel, Ben   +14 more
core   +1 more source

TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity

eLife, 2023
Monocytes are heterogeneous innate effector leukocytes generated in the bone marrow and released into circulation in a CCR2-dependent manner. During infection or inflammation, myelopoiesis is modulated to rapidly meet the demand for more effector cells ...
William D Jackson, Chiara Giacomassi, Sophie Ward, Amber Owen, Tiago C Luis, Sarah Spear, Kevin J Woollard, Cecilia Johansson, Jessica Strid, Marina Botto   +9 more
doaj   +1 more source

ZNF423: A New Player in Estrogen Receptor-Positive Breast Cancer

Frontiers in Endocrinology, 2018
Preventive therapy can target hormone-responsive breast cancer (BC) by treatment with selective estrogen receptor modulators (SERMs) and reduce the incidence of BC.
Heather M. Bond, Stefania Scicchitano, Emanuela Chiarella, Nicola Amodio, Valeria Lucchino, Annamaria Aloisio, Ylenia Montalcini, Maria Mesuraca, Giovanni Morrone   +8 more
doaj   +1 more source

Fat for fuel: lipid metabolism in haematopoiesis

Clinical & Translational Immunology, 2019
The importance of metabolic regulation in the immune system has launched back into the limelight in recent years. Various metabolic pathways have been examined in the context of their contribution to maintaining immune cell homeostasis and function ...
Gerard Pernes, Michelle C Flynn, Graeme I Lancaster, Andrew J Murphy   +3 more
doaj   +1 more source

Mechanisms controlling anaemia in Trypanosoma congolense infected mice. [PDF]

, 2009
Trypanosoma congolense are extracellular protozoan parasites of the blood stream of artiodactyls and are one of the main constraints on cattle production in Africa.
A Kobayashi, A Shamseddine, AI Su, AJ Nok, Andy Brass, B Mertens, B Stijlemans, B Stijlemans, B Vanhollebeke, Birgit Rathkolb, BM Bolstad, C Beaumont, C Li, CA Facer, CA Schaer, Delnaz Roshandel, DM Wrighting, E Nemeth, E Nemeth, E Nemeth, Eckard Wolf, Fuad Iraqi, G Weiss, Gd Haan, Gordon Langsley, Harry A. Noyes, HC Greenblatt, Helen Hulme, Helmut Fuchs, HH Kazazian, J Naessens, J Naessens, J Naessens, J Naessens, Jan Naessens, JCM Trail, KAN Esievo, KC Corbit, LY Shih, M Murray, M Murray, M Shi, M Shi, M Sileghem, M Sileghem, Martin Hrabé de Angelis, Mohammad H. Alimohammadian, Morris Agaba, MR Rifkin, N Mabbott, O Van Assendaelft, PM Kristjanson, R Ferreira, RC Gregory, RH Wang, RKG Assoku, RM Ngure, S Kemp, S Kierstein, S Magez, S Magez, S Taniguchi, SH Goh, SJ Kemp, SK Moestrup, Stephen Kemp, T Sato, TC Cheng, Valerie Gailus-Durner, VO Anosa, W Morrison, W Morrison, W Zumkeller, Y Liang, Y Nakamura   +74 more
core   +3 more sources

Turning Stem Cells Bad: Generation of Clinically Relevant Models of Human Acute Myeloid Leukemia through Gene Delivery- or Genome Editing-Based Approaches

Molecules, 2018
Acute myeloid leukemia (AML), the most common acute leukemia in the adult, is believed to arise as a consequence of multiple molecular events that confer on primitive hematopoietic progenitors unlimited self-renewal potential and cause defective ...
Maria Mesuraca, Nicola Amodio, Emanuela Chiarella, Stefania Scicchitano, Annamaria Aloisio, Bruna Codispoti, Valeria Lucchino, Ylenia Montalcini, Heather M. Bond, Giovanni Morrone   +9 more
doaj   +1 more source

The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells [PDF]

, 2012
Background: Although GATA1 is one of the most extensively studied haematopoietic transcription factors little is currently known about the physiological functions of its naturally occurring isoforms GATA1s and GATA1FL in humans—particularly whether the ...
A Quintas-Cardama, A Zipursky, AG Muntean, AG Muntean, Brenda Gibson, C Halsey, C Kuhl, Christina Halsey, CS McKimmie, Derek Gilchrist, Gerard Graham, H Sakamoto, I Matsumura, J Wechsler, JD Crispino, JP Bourquin, K Georgopoulos, KA Alford, L Gutierrez, LC Andersson, LM Hollanda, M Ritter, Marie Docherty, ME Greene, Mhairi McNeill, Michelle Le Brocq, N Shimokawa, N Suzuki, N Ueki, O Tunstall-Pedoe, PA Tetteroo, R Alitalo, R Calligaris, R Ferreira, RA Shivdasani, S Pearson-White, S Teichler, T Nomura, Y Ge, Z Li   +39 more
core   +2 more sources

Adhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid Leukaemia

Frontiers in Immunology, 2021
In the bone marrow (BM) of adult mammals, haematopoietic stem cells (HSCs) are retained in micro-anatomical structures by adhesion molecules that regulate HSC quiescence, proliferation and commitment.
Julien M. P. Grenier, Céline Testut, Cyril Fauriat, Stéphane J. C. Mancini, Michel Aurrand-Lions   +4 more
doaj   +1 more source