Results 211 to 220 of about 10,512 (289)

Biomarkers in clonal haematopoiesis of indeterminate potential (CHIP) linking cardiovascular diseases, myeloid neoplasms and inflammation. [PDF]

Ann Hematol
Tan HSV, Jiang H, Wang SSY.
europepmc   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Comparative Insights into Haematopoiesis: Blood Cell Development in Fish and Vertebrates

Malek Mansour, Mahmoud Shoeib, Safwat Ebada Mohamed Morsi, Galal Ahmed El-Sayed Yousse, Mohamed A. El-Sayed   +4 more
openalex   +1 more source

Extramedullary haematopoiesis - spleen

, 2021
openaire   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Association of clonal haematopoiesis with heart failure incidence and outcomes: A systematic review and meta-analysis. [PDF]

Eur J Heart Fail
Karakasis P, Lefkou E, Pamporis K, Farmakis D, Patoulias D, Antoniadis AP, Heymans S, Filippatos G, Fragakis N.   +8 more
europepmc   +1 more source

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, EarlyView.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source

Prognostic significance of somatic mutations in myeloid cells of men with chronic heart failure - interaction between loss of Y chromosome and clonal haematopoiesis. [PDF]

Eur J Heart Fail
Cremer S, von Scheidt M, Kirschbaum K, Tombor L, Mas-Peiro S, Abplanalp W, Rasper T, Ware A, Schuff A, Berkowitsch A, Krefting J, Leistner D, Schunkert H, Speer T, Dimmeler S, Zeiher AM.   +15 more
europepmc   +1 more source

Single‐Cell Profiling: Any Scale, Any Size, All at Once

Advanced Science, EarlyView.
Traditional single‐cell technologies are constrained by cellular dimension and throughput scale, in addition to its inability preserve spatial information. With recent innovations, these technologies now allow high throughput, large‐sized cell, and multi‐modal profiling of patient samples, overcoming these limitations.
Denise Goh, Felicia Wee, Rachel Elizabeth Ann Fincham, Ruisi Li, Joe Yeong   +4 more
wiley   +1 more source

Organoids in Haematologic Research: Advances and Future Directions. [PDF]

Cell Prolif
Chang L, Li L, Han Y, Cheng H, Yang L.
europepmc   +1 more source