Results 241 to 250 of about 10,512 (289)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

The emerging role of clonal haematopoiesis in the pathogenesis of dilated cardiomyopathy. [PDF]

Eur Heart J
Verdonschot JAJ, Fuster JJ, Walsh K, Heymans SRB.   +3 more
europepmc   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

Clonal tracing with somatic epimutations reveals dynamics of blood ageing. [PDF]

Nature
Scherer M, Singh I, Braun MM, Szu-Tu C, Sanchez Sanchez P, Lindenhofer D, Jakobsen NA, Körber V, Kardorff M, Nitsch L, Kautz P, Rühle J, Bianchi A, Cozzuto L, Frömel R, Beneyto-Calabuig S, Lareau C, Satpathy AT, Beekman R, Steinmetz LM, Raffel S, Ludwig LS, Vyas P, Rodriguez-Fraticelli A, Velten L.   +24 more
europepmc   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

The Effect of Anti-Activin Receptor Type IIA and Type IIB Antibody on Muscle, Bone and Blood in Healthy and Osteosarcopenic Mice. [PDF]

J Cachexia Sarcopenia Muscle
Bromer FD, Lodberg A, Eijken M, Andersen CBF, Poulsen MF, Thomsen JS, Brüel A.   +6 more
europepmc   +1 more source

CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels

Advanced Science, EarlyView.
ABSTRACT Bone angiogenesis is important for bone formation and regeneration after bone injury. Endothelial‐derived angiogenic factors are key signal transducers in the bone microenvironment and maintain vascular–osteogenic coupling during bone regeneration.
Qiong Lu, Qiyue Zheng, Zhaokai Zhou, Yajun Chen, Yun Chen, Wenjie Chen, Jiaojiao Wang, Ren Guo, Ren Wu, Lina Chen   +9 more
wiley   +1 more source

Childhood brain tumours instruct cranial haematopoiesis and immunotolerance

Cooper E, Posner DA, Lee CY, Hu L, Bonner S, Taylor JT, Baldwin O, Jimenez-Guerrero R, Masih KE, Rahrmann KW, Eigenbrood J, Ngo G, Porcu L, Roamio Franklin VN, D’Santos CS, Mair R, Santarius T, Craven C, Jalloh I, Vicente JM, Halim TYF, Wang L, Kreigstien AR, Swartling FJ, Khan J, Clatworthy MR, Gilbertson RJ.   +26 more
europepmc   +1 more source

Revolutionising Cardio-Oncology Care with Precision Genomics. [PDF]

Int J Mol Sci
Chong JH, Chuah CTH, Lee CG.
europepmc   +1 more source

Extramedullary haematopoiesis - thalassaemia

, 2011
openaire   +1 more source