Results 21 to 30 of about 28,636 (337)

Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias.

European Heart Journal, 2023
BACKGROUND AND AIMS Clonal haematopoiesis of indeterminate potential (CHIP), the age-related expansion of blood cells with preleukemic mutations, is associated with atherosclerotic cardiovascular disease and heart failure.
A. Schuermans, C. Vlasschaert, V. Nauffal, S. M. Cho, M. Uddin, T. Nakao, A. Niroula, M. Klarqvist, L. Weeks, A. E. Lin, Seyedmohammad Saadatagah, Kim Lannery, Megan Wong, W. Hornsby, S. Lubitz, C. Ballantyne, S. Jaiswal, Peter Libby, B. Ebert, A. Bick, P. Ellinor, P. Natarajan, M. Honigberg   +22 more
semanticscholar   +1 more source

Common and rare variant associations with clonal haematopoiesis phenotypes

Nature, 2022
Clonal haematopoiesis involves the expansion of certain blood cell lineages and has been associated with ageing and adverse health outcomes1–5. Here we use exome sequence data on 628,388 individuals to identify 40,208 carriers of clonal haematopoiesis of
M. D. Kessler, A. Damask, S. O’Keeffe, N. Banerjee, Dadong Li, Kyoko Watanabe, Anthony Marketta, Michael Van Meter, S. Semrau, J. Horowitz, Jing Tang, J. Kosmicki, V. Rajagopal, Yuxin Zou, Y. Houvras, Arkopravo Ghosh, Christopher E. Gillies, J. Mbatchou, Ryan R. White, N. Verweij, J. Bovijn, N. Parikshak, M. LeBlanc, Marcus Jones, D. J. Glass, L. Lotta, M. Cantor, G. Atwal, A. Locke, M. Ferreira, R. Deering, C. Paulding, A. Shuldiner, G. Thurston, A. Ferrando, W. Salerno, J. Reid, J. Overton, J. Marchini, H. Kang, A. Baras, G. Abecasis, E. Jorgenson   +42 more
semanticscholar   +1 more source

Pulmonary extramedullary haematopoiesis [PDF]

BMJ Case Reports, 2011
A 72-year-old Caucasian lady with myeloproliferative disorder was admitted for evaluation of progressive dyspnoea, weight loss, fatigue and mild hypoxia. A diffuse ground glass opacity was seen on CT pulmonary angiogram. Differential diagnoses included heart failure, infection, progression of myeloproliferative disorder with extramedullary ...
Stephen Fanning, Veenu Mubarak, Simon D. Bowler, Morgon Windsor, Edwina Duhig   +4 more
openaire   +3 more sources

The longitudinal dynamics and natural history of clonal haematopoiesis

Nature, 2021
Clonal expansions driven by somatic mutations become pervasive across human tissues with age, including in the haematopoietic system, where the phenomenon is termed clonal haematopoiesis1–4.
M. Fabre, José Guilherme de Almeida, E. Fiorillo, E. Mitchell, Aristi Damaskou, Justyna Rak, V. Orrù, Michele Marongiu, M. Vijayabaskar, J. Baxter, Claire W. Hardy, F. Abascal, M. Chapman, N. Williams, J. Nangalia, I. Martincorena, P. Campbell, E. McKinney, F. Cucca, M. Gerstung, G. Vassiliou   +20 more
semanticscholar   +1 more source

BloodSpot 3.0: a database of gene and protein expression data in normal and malignant haematopoiesis

Nucleic Acids Research, 2023
BloodSpot is a specialised database integrating gene expression data from acute myeloid leukaemia (AML) patients related to blood cell development and maturation. The database and interface has helped numerous researchers and clinicians to quickly get an
M. H. Gíslason, Gül Sude Demircan, Marek Prachar, B. Furtwängler, J. Schwaller, E. Schoof, B. Porse, Nicolas Rapin, F. O. Bagger   +8 more
semanticscholar   +1 more source

Vitamin D and Haematopoiesis [PDF]

Current Tissue Microenvironment Reports, 2020
AbstractPurpose of ReviewThis review examines the influences of active vitamin D on ‘developmental’ haematopoiesis and the immune cells produced. Haematopoiesis gives rise to the platelets, erythrocytes and a wide range of immune cell types each of which performs a specific role to protect the organism from a myriad of infectious agents.
Ewa Marcinkowska, Geoffrey Brown, Andrzej Kutner   +2 more
openaire   +1 more source

Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR

Nature Communications, 2023
The generation of primitive macrophages remains a poorly understood process in humans. Here, the authors identify placental erythro-myeloid progenitors that give rise to foetal macrophages in the early human placenta and demonstrate that epigenetic ...
Jake R. Thomas, Anna Appios, Emily F. Calderbank, Nagisa Yoshida, Xiaohui Zhao, R. Hamilton, A. Moffett, A. Sharkey, E. Laurenti, C. Hanna, N. McGovern   +10 more
semanticscholar   +1 more source

GATA2 mitotic bookmarking is required for definitive haematopoiesis

Nature Communications, 2023
In mitosis, most transcription factors detach from chromatin, but some are retained and bookmark genomic sites. Mitotic bookmarking has been implicated in lineage inheritance, pluripotency and reprogramming.
Rita Silvério-Alves, I. Kurochkin, Anna Rydström, Camila Vazquez Echegaray, Jakob Haider, M. Nicholls, C. Rode, Louise Thelaus, A. Lindgren, A. G. Ferreira, R. Brandao, Jonas Larsson, M. D. de Bruijn, Javier Martín-González, C. Pereira   +14 more
semanticscholar   +1 more source

Zebrafish Caudal Haematopoietic Embryonic Stromal Tissue (CHEST) Cells Support Haematopoiesis. [PDF]

, 2017
Haematopoiesis is an essential process in early vertebrate development that occurs in different distinct spatial locations in the embryo that shift over time.
Aggio, Julian, Campbell, Clyde, Marquez, Gabriel, Stachura, David L, Traver, David, Wolf, Anja, Wright, Francis   +6 more
core   +1 more source

Drosophila haematopoiesis

Cellular Microbiology, 2007
Like in vertebrates, Drosophila haematopoiesis occurs in two waves. It gives rise to three types of haemocytes: plasmatocytes (phagocytosis), crystal cells (melanization) and lamellocytes (encapsulation of parasites). A first population of haemocytes, specified during embryogenesis, gives rise to an invariant number of plasmatocytes and crystal cells ...
Marie Meister, Michèle Crozatier
openaire   +3 more sources