The discovery of lymphatic system as a turning point in medical knowledge: Aselli, Pecquet and the end of hepatocentrism [PDF]
, 2017 In this paper, I would like to analyse the impact of the discovery of lymphatic system on the development of the modern conception of human body. The discovery of lymphatics, as that of blood circulation, has in fact questioned important tenets of Galen ...
Tonetti, Luca
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Biomedical Research Journal, 2016 Haematopoiesis is severely hampered after exposure to ionizing radiations. Role of polyunsaturated fatty acids (PUFAs) during embryonic development as well as during various physiological processes is well established.
Kedar Limbkar +2 more
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Chronic myelomonocytic leukaemia stem cell transcriptomes anticipate disease morphology and outcome
EBioMedicine, 2020 Background: Chronic myelomonocytic leukaemia (CMML) is a clinically heterogeneous stem cell malignancy with overlapping features of myelodysplasia and myeloproliferation. Over 90% of patients carry mutations in epigenetic and/or splicing genes, typically
Daniel H Wiseman +6 more
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Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans
eLife, 2022 Background: Ageing is a heterogenous process characterised by cellular and molecular hallmarks, including changes to haematopoietic stem cells and is a primary risk factor for chronic diseases.
Amy L Roberts +15 more
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The Ribosome Biogenesis Protein Nol9 Is Essential for Definitive Hematopoiesis and Pancreas Morphogenesis in Zebrafish. [PDF]
, 2015 Ribosome biogenesis is a ubiquitous and essential process in cells. Defects in ribosome biogenesis and function result in a group of human disorders, collectively known as ribosomopathies.
Barroso, Inês +11 more
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Frontiers in Physiology, 2022 The haematopoietic system is a classical stem cell hierarchy that maintains all the blood cells in the body. Haematopoietic stem cells (HSCs) are rare, highly potent cells that reside at the apex of this hierarchy and are historically some of the most ...
Beatrice Rix +3 more
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Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukaemia [PDF]
, 2017 Acute Myeloid Leukaemia (AML) develops when there is a block in differentiation and uncontrolled proliferation of myeloid precursors, resulting in bone marrow failure.
Gibson, Brenda E.S. +3 more
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SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development [PDF]
Open Biology, 2016 During embryogenesis, the three SOXF transcription factors, SOX7, SOX17 and SOX18, regulate the specification of the cardiovascular system and are also involved in the development of haematopoiesis.
Sara Cuvertino +2 more
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Regulation of NF-κB by PML and PML-RARα [PDF]
, 2017 Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation.
Ahmed, Abrar +8 more
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Predictors and Consequences of Anaemia Among Antiretroviral-Naïve HIV-Infected and HIV-Uninfected Children in Tanzania. [PDF]
, 2009 Predictors and consequences of childhood anaemia in settings with high HIV prevalence are not well known. The aims of the present study were to identify maternal and child predictors of anaemia among children born to HIV-infected women and to study the ...
Adewuyi +13 more
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