Results 21 to 30 of about 10,512 (289)
South African Medical Journal, 2019 Human immunodeficiency virus (HIV) infection not only leads to a compromised immune system, but also disrupts normal haematopoiesis, resulting in the frequent manifestation of cytopenias (anaemia, thrombocytopenia and neutropenia). Although there is a definite association between the severity of cytopenia and HIV disease stage, this relationship is not
Durandt, Chrisna +7 more
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Biomedical Research Journal, 2016 Haematopoiesis is severely hampered after exposure to ionizing radiations. Role of polyunsaturated fatty acids (PUFAs) during embryonic development as well as during various physiological processes is well established.
Kedar Limbkar +2 more
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Chronic myelomonocytic leukaemia stem cell transcriptomes anticipate disease morphology and outcome
EBioMedicine, 2020 Background: Chronic myelomonocytic leukaemia (CMML) is a clinically heterogeneous stem cell malignancy with overlapping features of myelodysplasia and myeloproliferation. Over 90% of patients carry mutations in epigenetic and/or splicing genes, typically
Daniel H Wiseman +6 more
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Frontiers in Immunology, 2021 In the bone marrow (BM) of adult mammals, haematopoietic stem cells (HSCs) are retained in micro-anatomical structures by adhesion molecules that regulate HSC quiescence, proliferation and commitment.
Julien M. P. Grenier +4 more
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Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans
eLife, 2022 Background: Ageing is a heterogenous process characterised by cellular and molecular hallmarks, including changes to haematopoietic stem cells and is a primary risk factor for chronic diseases.
Amy L Roberts +15 more
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Frontiers in Physiology, 2022 The haematopoietic system is a classical stem cell hierarchy that maintains all the blood cells in the body. Haematopoietic stem cells (HSCs) are rare, highly potent cells that reside at the apex of this hierarchy and are historically some of the most ...
Beatrice Rix +3 more
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SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development [PDF]
Open Biology, 2016 During embryogenesis, the three SOXF transcription factors, SOX7, SOX17 and SOX18, regulate the specification of the cardiovascular system and are also involved in the development of haematopoiesis.
Sara Cuvertino +2 more
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Agricultural Science, 2021 The study aimed to investigate how the local product ZooBioR, obtained by modern technologies from Spirulina platensis, influences the health and, in particular, the parameters-markers of the clinical and haema-tological status in hens, in the first ...
Gheorghe PISTOL +3 more
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Pediatric haematopoiesis and related malignancies
Oncology Letters, 2017 Survival after acute paediatric (0-14 years), adolescent (15-19 years) and young adult (20-39 years) leukaemia has improved substantially over the last five decades, particularly for acute lymphoblastic leukaemia (ALL) and acute promyelocytic leukaemia.
Mingwei Jin, Shumei Xu, Qi An
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Germline risk of clonal haematopoiesis [PDF]
Nature Reviews Genetics, 2021 Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with somatic mutations that is associated with an increased risk of haematological malignancies, cardiovascular disease and all-cause mortality. CH may be caused by point mutations in genes associated with myeloid neoplasms, chromosomal copy number changes and loss of ...
Alexander J. Silver +2 more
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