Results 31 to 40 of about 28,636 (337)

The MLL/SET family and haematopoiesis [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2020
As demonstrated through early work in Drosophila, members of the MLL/SET family play essential roles during embryonic development through their participation in large protein complexes that are central to epigenetic regulation of gene expression. One of its members, MLL1, has additionally received a lot of attention as it is a potent oncogenic driver ...
Antunes, Eric, Ottersbach, Katrin
openaire   +3 more sources

The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain [PDF]

, 2020
Chromatin remodelling and transcription factors play important roles in lineage commitment and development through control of gene expression. Activation of selected lineage-specific genes and repression of alternative lineage-affiliated genes results in
Biasutto, Antonio J, Gilbert, Robert C G, Karia, Dimple, Mancini, Erika J, Porcher, Catherine   +4 more
core   +1 more source

Disordered haematopoiesis and athero-thrombosis [PDF]

European Heart Journal, 2016
Atherosclerosis, the major underlying cause of cardiovascular disease, is characterized by a lipid-driven infiltration of inflammatory cells in large and medium arteries. Increased production and activation of monocytes, neutrophils, and platelets, driven by hypercholesterolaemia and defective high-density lipoproteins-mediated cholesterol efflux ...
Andrew Murphy, Alan R. Tall
openalex   +4 more sources

Haemogenic endocardium contributes to transient definitive haematopoiesis. [PDF]

, 2013
Haematopoietic cells arise from spatiotemporally restricted domains in the developing embryo. Although studies of non-mammalian animal and in vitro embryonic stem cell models suggest a close relationship among cardiac, endocardial and haematopoietic ...
Arshi, Armin, Conway, Simon J., Harmon, Andrew W., Harvey, Richard P., Liu, Xiaoqian, Mikkola, Hanna K. A., Nakano, Atsushi, Nakano, Haruko, Nakano, Haruko, Nakashima, Yasuhiro, Pashmforoush, Mohammad, Sasidharan, Rajkumar, Schwartz, Robert J., Shin, Jae-Ho, van Handel, Ben   +14 more
core   +1 more source

Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis

Nature Communications, 2022
The sympathetic nervous system has been evolutionary selected to respond to stress and activates haematopoietic stem cells via noradrenergic signals. However, the pathways preserving haematopoietic stem cell quiescence and maintenance under proliferative
C. Fielding, A. García-García, C. Korn, S. Gadomski, Zijian Fang, J. L. Reguera, J. Pérez-Simón, B. Göttgens, S. Méndez-Ferrer   +8 more
semanticscholar   +1 more source

Clonal haematopoiesis of indeterminate potential: associations with heart failure incidence, clinical parameters and biomarkers

European Journal of Heart Failure, 2022
We aimed to analyse the association of clonal haematopoiesis of indeterminate potential (CHIP) with incident heart failure (HF) in a European population cohort.
C. Shi, J. Aboumsallem, N. Suthahar, A. D. de Graaf, J. Jansen, I. V. van Zeventer, V. Bračun, S. de Wit, E. Screever, P. F. van den Berg, W. Meijers, R. Gansevoort, S. Bakker, P. van der Harst, H. Silljé, G. Huls, Rudolf A. de Boer   +16 more
semanticscholar   +1 more source

The discovery of lymphatic system as a turning point in medical knowledge: Aselli, Pecquet and the end of hepatocentrism [PDF]

, 2017
In this paper, I would like to analyse the impact of the discovery of lymphatic system on the development of the modern conception of human body. The discovery of lymphatics, as that of blood circulation, has in fact questioned important tenets of Galen ...
Tonetti, Luca
core   +2 more sources

Associations of clonal haematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke.

Blood, 2022
Clonal hematopoiesis (CH) is common among older people and associated with an increased risk of atherosclerosis, inflammation, and shorter overall survival.
C. M. Arends, T. Liman, P. Strzelecka, A. Kufner, P. Löwe, Shufan Huo, Catarina M Stein, S. K. Piper, Marlon Tilgner, P. S. Sperber, Savvina Dimitriou, P. Heuschmann, Raphael Hablesreiter, C. Harms, L. Bullinger, J. Weber, M. Endres, Frederik Damm   +17 more
semanticscholar   +1 more source

The Ribosome Biogenesis Protein Nol9 Is Essential for Definitive Hematopoiesis and Pancreas Morphogenesis in Zebrafish. [PDF]

, 2015
Ribosome biogenesis is a ubiquitous and essential process in cells. Defects in ribosome biogenesis and function result in a group of human disorders, collectively known as ribosomopathies.
Barroso, Inês, Bielczyk-Maczyńska, Ewa, Cvejic, Ana, Fernández-Pevida, Antonio, Ferreira, Lauren, Fleischmann, Tobias, Harvey, Steven A, Lam Hung, Laure, Stemple, Derek L, Wali, Neha, Warren, Alan J, Weis, Félix   +11 more
core   +9 more sources

The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells [PDF]

, 2012
Background: Although GATA1 is one of the most extensively studied haematopoietic transcription factors little is currently known about the physiological functions of its naturally occurring isoforms GATA1s and GATA1FL in humans—particularly whether the ...
A Quintas-Cardama, A Zipursky, AG Muntean, AG Muntean, Brenda Gibson, C Halsey, C Kuhl, Christina Halsey, CS McKimmie, Derek Gilchrist, Gerard Graham, H Sakamoto, I Matsumura, J Wechsler, JD Crispino, JP Bourquin, K Georgopoulos, KA Alford, L Gutierrez, LC Andersson, LM Hollanda, M Ritter, Marie Docherty, ME Greene, Mhairi McNeill, Michelle Le Brocq, N Shimokawa, N Suzuki, N Ueki, O Tunstall-Pedoe, PA Tetteroo, R Alitalo, R Calligaris, R Ferreira, RA Shivdasani, S Pearson-White, S Teichler, T Nomura, Y Ge, Z Li   +39 more
core   +2 more sources