Results 31 to 40 of about 10,512 (289)

Mask Protection Against Lead Exposure and Its Correlation with Erythropoiesis in Automotive Body Painters at Ligu District, Semarang, Indonesia

Journal of Blood Medicine, 2022
Budi Santosa,1 Ali Rosidi,2 Herlisa Anggraini,3 Zahra Maharani Latrobdiba,2 Fitriani Nur Damayanti,4 Heru Santoso Wahito Nugroho5 1Department of Medical Laboratory Science, Universitas Muhammadiyah Semarang, Semarang, Indonesia; 2Department of Nutrition,
Santosa B, Rosidi A, Anggraini H, Latrobdiba ZM, Damayanti FN, Nugroho HSW   +5 more
doaj  

Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks

Cells, 2020
Acute myeloid leukaemia (AML) is a haematopoietic malignancy caused by a combination of genetic and epigenetic lesions. Activation of the oncoprotein FLT3 ITD (Fms-like tyrosine kinase with internal tandem duplications) represents a key driver mutation ...
Isabel Bär, Volker Ast, Daria Meyer, Rainer König, Martina Rauner, Lorenz C. Hofbauer, Jörg P. Müller   +6 more
doaj   +1 more source

Therapeutic Modulation of Autophagy in Leukaemia and Lymphoma

Cells, 2019
Haematopoiesis is a tightly orchestrated process where a pool of hematopoietic stem and progenitor cells (HSPCs) with high self-renewal potential can give rise to both lymphoid and myeloid lineages.
Mojgan Djavaheri-Mergny, Sylvie Giuriato, Mario P. Tschan, Magali Humbert   +3 more
doaj   +1 more source

Effect of simvastatin on thrombopoiesis in porcine bone marrow

Journal of Veterinary Research, 2019
Introduction: Statins are pharmacological agents commonly used to lower serum cholesterol level. The aim of the experiment was to investigate the effect of the statin simvastatin on thrombopoiesis in the porcine model because it is the closest to the ...
Snarska Anna, Wysocka Dominika, Rytel Liliana   +2 more
doaj   +1 more source

Irradiation Haematopoiesis Recovery Orchestrated by IL-12/IL-12Rβ1/TYK2/STAT3-Initiated Osteogenic Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells

Frontiers in Cell and Developmental Biology, 2021
PurposeRepairing the irradiation-induced osteogenic differentiation injury of bone marrow mesenchymal stem cells (BM-MSCs) is beneficial to recovering haematopoiesis injury in radiotherapy; however, its mechanism is elusive.
Fengjie Li, Rong Zhang, Changpeng Hu, Qian Ran, Yang Xiang, Lixin Xiang, Li Chen, Yang Yang, Shengwen Calvin Li, Gang Zhang, Zhongjun Li   +10 more
doaj   +1 more source

Type I interferon signaling controls the early hematopoietic expansion in response to β-glucan

iScience
Summary: Rapid hematopoietic adaptations are important for building and sustaining the biological response to β-glucan. The signals involved in these early events have not yet been fully explored. Given that type I interferons are produced in response to
Yangsong Xu, Man K.S. Lee, Nicole A. de Weerd, Ziyue Fu, Camilla Bertuzzo Veiga, Dragana Dragoljevic, Dmitri Sviridov, Paul J. Hertzog, Andrew J. Fleetwood, Andrew J. Murphy   +9 more
doaj   +1 more source

Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes

Disease Models & Mechanisms, 2021
Down syndrome (DS), trisomy 21, results in many complex phenotypes including cognitive deficits, heart defects and craniofacial alterations. Phenotypes arise from an extra copy of human chromosome 21 (Hsa21) genes.
Eva Lana-Elola, Heather Cater, Sheona Watson-Scales, Simon Greenaway, Jennifer Müller-Winkler, Dorota Gibbins, Mihaela Nemes, Amy Slender, Tertius Hough, Piia Keskivali-Bond, Cheryl L. Scudamore, Eleanor Herbert, Gareth T. Banks, Helene Mobbs, Tara Canonica, Justin Tosh, Suzanna Noy, Miriam Llorian, Patrick M. Nolan, Julian L. Griffin, Mark Good, Michelle Simon, Ann-Marie Mallon, Sara Wells, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz   +25 more
doaj   +1 more source

Biomechanical forces promote embryonic haematopoiesis [PDF]

Nature, 2009
Biomechanical forces are emerging as critical regulators of embryogenesis, particularly in the developing cardiovascular system. After initiation of the heartbeat in vertebrates, cells lining the ventral aspect of the dorsal aorta, the placental vessels, and the umbilical and vitelline arteries initiate expression of the transcription factor Runx1 ...
Luigi, Adamo, Olaia, Naveiras, Pamela L, Wenzel, Shannon, McKinney-Freeman, Peter J, Mack, Jorge, Gracia-Sancho, Astrid, Suchy-Dicey, Momoko, Yoshimoto, M William, Lensch, Mervin C, Yoder, Guillermo, García-Cardeña, George Q, Daley   +11 more
openaire   +2 more sources

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

Potential Early Risk Biomarkers for Reduced Forced Expiratory Volume in Children Post‐Hematopoietic Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We sought to identify potential early risk biomarkers for lung disease in children post‐allogeneic HCT. Patients with pulmonary function tests 3 months post‐transplant and plasma samples between days 7 and 14 post‐HCT were included. Six of 27 subjects enrolled had reduced forced expiratory volume 1 (FEV1) z scores.
Isabella S. Small, Pi Chun Cheng, April L. Rahrig, Courtney M. Rowan   +3 more
wiley   +1 more source