Results 31 to 40 of about 22,731 (338)

Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans

eLife, 2022
Background: Ageing is a heterogenous process characterised by cellular and molecular hallmarks, including changes to haematopoietic stem cells and is a primary risk factor for chronic diseases.
Amy L Roberts, Alessandro Morea, Ariella Amar, Antonino Zito, Julia S El-Sayed Moustafa, Max Tomlinson, Ruth CE Bowyer, Xinyuan Zhang, Colette Christiansen, Ricardo Costeira, Claire J Steves, Massimo Mangino, Jordana T Bell, Chloe CY Wong, Timothy J Vyse, Kerrin S Small   +15 more
doaj   +1 more source

Fat for fuel: lipid metabolism in haematopoiesis

Clinical & Translational Immunology, 2019
The importance of metabolic regulation in the immune system has launched back into the limelight in recent years. Various metabolic pathways have been examined in the context of their contribution to maintaining immune cell homeostasis and function ...
Gerard Pernes, Michelle C Flynn, Graeme I Lancaster, Andrew J Murphy   +3 more
doaj   +1 more source

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development [PDF]

, 2011
The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation and ...
Abramoff, Abtahian, Alice Y. Pollitt, Aparicio-Vergara, Bertozzi, Bohmer, Brenda A. Finney, Caetano Reis e Sousa, Carramolino, Caton, Cecile Bénézech, Chagraoui, Cheng, Christou, Clausen, Colonna, Craig E. Hughes, Cueni, de Boer, Diego Mourao-Sa, Edina Schweighoffer, Francesca Barone, Gerard B. Nash, Gustafsson, Hodivala-Dilke, Hughes, Hughes, Humphreys, Ichise, Kate L. Lowe, Kaufmann, Kerrigan, Leyre Navarro-Núñez, Makinen, Martin-Villar, May, Mocsai, Mourao-Sa, Navarro, Navarro, Nicholas Smithers, Nieswandt, Pardridge, Ramirez, Saijo, Schacht, Sebzda, Spalton, Stacey A. Langan, Steve P. Watson, Steve Sheardown, Suzuki-Inoue, Suzuki-Inoue, Suzuki-Inoue, Suzuki-Inoue, Tammela, Tang, Tiedt, Tober, Turner, Uhrin, Victor L. J. Tybulewicz, Warburton, Watson, Williams, Xie, Xu   +66 more
core   +2 more sources

Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach [PDF]

, 2020
Haematopoiesis is the process of generation of blood cells. Lymphopoiesis generates lymphocytes, the cells in charge of the adaptive immune response. Disruptions of this process are associated with diseases like leukaemia, which is especially incident in children.
arxiv   +1 more source

ZNF423: A New Player in Estrogen Receptor-Positive Breast Cancer

Frontiers in Endocrinology, 2018
Preventive therapy can target hormone-responsive breast cancer (BC) by treatment with selective estrogen receptor modulators (SERMs) and reduce the incidence of BC.
Heather M. Bond, Stefania Scicchitano, Emanuela Chiarella, Nicola Amodio, Valeria Lucchino, Annamaria Aloisio, Ylenia Montalcini, Maria Mesuraca, Giovanni Morrone   +8 more
doaj   +1 more source

Consequences of HIV infection in the bone marrow niche

Frontiers in Immunology, 2023
Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV infection contributes to haematological abnormalities observed in HIV patients.
Candice Lee Herd, Juanita Mellet, Tsungai Mashingaidze, Chrisna Durandt, Michael Sean Pepper   +4 more
doaj   +1 more source

Dysregulation of NIPBL leads to impaired RUNX1 expression and hematopoietic defects [PDF]

, 2020
The transcription factor RUNX1, a pivotal regulator of HSCs and haematopoiesis, is a frequent target of chromosomal translocations, point mutations or altered gene/protein dosage.
A. Biondi, A. Marozzi, A. Pezzotta, A. PIstocchi, A. Rigamonti, C. Saitta, E. Bresciani, G. Cazzaniga, G. Fazio, G. Gaudenzi, L. Ferrari, M. Fumagalli, M. Mazzola, M. Parma, M. Pelleri   +14 more
core   +1 more source

Oral feeding with Arachidonic Acid (AA) and Docosahexanoic Acid (DHA) help in better recovery of haematopoiesis in sub-lethally irradiated mice

Biomedical Research Journal, 2016
Haematopoiesis is severely hampered after exposure to ionizing radiations. Role of polyunsaturated fatty acids (PUFAs) during embryonic development as well as during various physiological processes is well established.
Kedar Limbkar, Vaijayanti Kale, Lalita Limaye   +2 more
doaj   +1 more source

TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity

eLife, 2023
Monocytes are heterogeneous innate effector leukocytes generated in the bone marrow and released into circulation in a CCR2-dependent manner. During infection or inflammation, myelopoiesis is modulated to rapidly meet the demand for more effector cells ...
William D Jackson, Chiara Giacomassi, Sophie Ward, Amber Owen, Tiago C Luis, Sarah Spear, Kevin J Woollard, Cecilia Johansson, Jessica Strid, Marina Botto   +9 more
doaj   +1 more source

Haemogenic endocardium contributes to transient definitive haematopoiesis. [PDF]

, 2013
Haematopoietic cells arise from spatiotemporally restricted domains in the developing embryo. Although studies of non-mammalian animal and in vitro embryonic stem cell models suggest a close relationship among cardiac, endocardial and haematopoietic ...
Arshi, Armin, Conway, Simon J., Harmon, Andrew W., Harvey, Richard P., Liu, Xiaoqian, Mikkola, Hanna K. A., Nakano, Atsushi, Nakano, Haruko, Nakano, Haruko, Nakashima, Yasuhiro, Pashmforoush, Mohammad, Sasidharan, Rajkumar, Schwartz, Robert J., Shin, Jae-Ho, van Handel, Ben   +14 more
core   +1 more source