Results 41 to 50 of about 154,412 (312)

Haemophilus influenzae induces steroid-resistant inflammatory responses in COPD. [PDF]

, 2017
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder partially resistant to glucocorticoids. A reduced histone deacetylase (HDAC) activity has been proposed to explain this resistance.
Agustí García-Navarro, Àlvar, Busquets, Xavier, Cosío, Borja G., Iglesias, Amanda, Jahn, Andreas, Shafiek, Hanaa   +5 more
core   +1 more source

How do nematodes transfer phosphorylcholine to carbohydrates? [PDF]

, 2010
An unusual aspect of the biology of nematodes is the attachment of phosphorylcholine (PC) to carbohydrate. The attachment appears to play an important role in nematode development and, in some parasitic species, in immunomodulation.
Harnett, W., Houston, K.M., Rzepecka, J.
core   +1 more source

Role of Haemophilus influenzae in Formation of Infectious Diseases in Children

Zdorovʹe Rebenka, 2013
The paper contains an analysis and synthesis of current views on the role of Haemophilus influenzae in the formation of infectious diseases in children.
G.O. Lezhenko, O.Ye. Pashkova, L.I. Pantyushenko   +2 more
doaj   +1 more source

The role of NTHi colonization and infection in the pathogenesis of neutrophilic asthma

Respiratory Research, 2020
Asthma is a complex heterogeneous disease. The neutrophilic subtypes of asthma are described as persistent, more severe and corticosteroid-resistant, with higher hospitalization and mortality rates, which seriously affect the lives of asthmatic patients.
Jing Zhang, Zhenxing Zhu, Xu Zuo, He Pan, Yinuo Gu, Yuze Yuan, Guoqiang Wang, Shiji Wang, Ruipeng Zheng, Zhongmin Liu, Fang Wang, Jingtong Zheng   +11 more
doaj   +1 more source

HAEMOPHILUS INFLUENZAE INFECTION IN CHILDREN DURING SPORADIC MORBIDITY: CLINICAL CASES WITH DIFFERENT (FAVORABLE OR FATAL) OUTCOMES

Вопросы современной педиатрии, 2017
Haemophilus influenzae infection in children is detected as sporadic cases and is characterized by polymorphism of clinical symptoms (rhinopharyngitis, purulent meningitis, acute epiglottitis, panniculitis, etc.), which complicates an early diagnosis and
Gennadii A. Kharchenko, Olga G. Kimirilova   +1 more
doaj   +1 more source

Cephalosporin-3’-diazeniumdiolate NO-donor prodrug PYRRO-C3D enhances azithromycin susceptibility of non-typeable Haemophilus influenzae biofilms [PDF]

, 2016
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Objectives: PYRRO-C3D is a cephalosporin-3-diazeniumdiolate nitric oxide (NO)-donor prodrug designed to ...
Allan, Raymond N., Coles, J., Collins, S. A., Connett, G., Faust, S. N., Feelisch, M., Hall-Stoodley, L., Halladay, G. D., Jackson, C. L., Kelso, M. J., Lucas, J. S. A., Rineh, A., Walker, W. T., Webb, J. S., Yepuri, N. R.   +14 more
core   +2 more sources

A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae

Nature Communications, 2015
Non-typeable Haemophilus influenzae contains an N6-adenine DNA-methyltransferase (ModA) that is subject to phase-variable expression (random ON/OFF switching).
John M. Atack, Y. Srikhanta, Kate L. Fox, J. Jurcisek, K. Brockman, Tyson A. Clark, Matthew Boitano, P. Power, F. Jen, A. McEwan, S. Grimmond, Arnold L. Smith, S. Barenkamp, J. Korlach, L. Bakaletz, M. Jennings   +15 more
semanticscholar   +1 more source

Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial

Advanced Science, EarlyView.
Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera, Suneesh Thilak, Asha Patel, Prashant Nasa, Zubair Ahmed, Lorraine Jacques, William J. Scotton, Cyril Chacko, Randeep Mullhi, Ruoling Chen, Vikram Patil, Suresh Renukappa, Tonny Veenith   +12 more
wiley   +1 more source

Vaccines for Nontypeable Haemophilus influenzae: the Future Is Now

Clinical and Vaccine Immunology, 2015
Infections due to nontypeable Haemophilus influenzae result in enormous global morbidity in two clinical settings: otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease (COPD).
T. Murphy
semanticscholar   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source