Results 51 to 60 of about 1,651 (113)

Pharmacokinetic–Pharmacodynamic Cutoff Values for Doxycycline in Pigs to Support the Establishment of Clinical Breakpoints for Antimicrobial Susceptibility Testing

Journal of Veterinary Pharmacology and Therapeutics, Volume 48, Issue 4, Page 300-317, July 2025.
ABSTRACT This meta‐analysis provides a population model of doxycycline (DOXY) disposition in pigs for computation of PK/PD cutoff values corresponding to differing modalities of DOXY administration orally in pigs. This analysis enables establishment of specific clinical breakpoints for the development of antimicrobial susceptibility testing of DOXY in ...
Pierre‐Louis Toutain, Alain Bousquet‐Melou, Aude A. Ferran, Béatrice B. Roques, Jérôme R. E. del Castillo, Peter Lees, Siska Croubels, Eric Bousquet, Ludovic Pelligand   +8 more
wiley   +1 more source

The AI-2/luxS Quorum Sensing System Affects the Growth Characteristics, Biofilm Formation, and Virulence of Haemophilus parasuis

Frontiers in Cellular and Infection Microbiology, 2019
Haemophilus parasuis (H. parasuis) is a kind of opportunistic pathogen of the upper respiratory tract of piglets. Under certain circumstances, virulent strains can breach the mucosal barrier and enter the bloodstream, causing severe Glässer's disease ...
Bingzhou Zhang, Xugang Ku, Xiaoqian Zhang, Yan Zhang, Guo Chen, Fangzhou Chen, Wei Zeng, Jing Li, Ling Zhu, Qigai He   +9 more
doaj   +1 more source

Rational Design of Natural Xanthones Against Gram‐negative Bacteria

Advanced Science, Volume 12, Issue 14, April 10, 2025.
The skeletons are screened and obtained from natural xanthones to penetrate the outer membrane (OM) in Gram‐negative bacteria. The analog of α‐mangostin functionalized with amine groups crosses the OM through a self‐promoted pathway. The design and elucidation of antibacterial compounds crossing the OM facilitates the discovery of novel compounds ...
Xiaojia Liu, Meirong Song, Ying Liu, Shuyu Yang, Shang Chen, Jijun Kang, Jianzhong Shen, Kui Zhu   +7 more
wiley   +1 more source

Whole‐Genomic Characterization of Two Different PRRSV‐1 Strains Isolated From a Single Pig

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Recent studies have demonstrated that porcine reproductive and respiratory syndrome virus 1 (PRRSV‐1) strains isolated from different farms in China have significant genomic heterogeneity, whereas strains from the same farm present a high degree of genomic similarity.
Bangjun Gong, Jiahao Shi, Hu Xu, Chao Li, Lirun Xiang, Zhenyang Guo, Jinhao Li, Siyu Zhang, Zixuan Feng, Haonan Kang, Xueli Zhang, Ziyu Song, Qian Wang, Jinmei Peng, Guohui Zhou, Chaoliang Leng, Kuan Zhao, Yan-Dong Tang, Huairan Liu, Tong-Qing An, Xuehui Cai, Zhi-Jun Tian, Hongliang Zhang, Nan-hua Chen   +23 more
wiley   +1 more source

Haemophilus parasuis cytolethal distending toxin induces cell cycle arrest and p53-dependent apoptosis.

PLoS ONE, 2017
Haemophilus parasuis is the causative agent of Glasser's disease in pigs. Cytolethal distending toxin (CDT) is an important virulence factor of H. parasuis.
Gang Li, Hui Niu, Yanhe Zhang, Yanling Li, Fang Xie, Paul R Langford, Siguo Liu, Chunlai Wang   +7 more
doaj   +1 more source

CRISPR/Cas system and its application in the diagnosis of animal infectious diseases

The FASEB Journal, Volume 38, Issue 24, 31 December 2024.
CRISPR‐based diagnostic platforms have transformed the molecular diagnostic field due to their outstanding ultra‐sensitive nucleic acid detecting capabilities. In this review, we highlighted the application of currently available CRISPR integrated setups on the diagnosis of animal infectious diseases.
Hafiz Muhammad Hamza Rasool, Qiwei Chen, Xiaowei Gong, Jizhang Zhou   +3 more
wiley   +1 more source

The establishment and application of a one‐step multiplex real‐time polymerase chain reaction assay for the detection of Streptococcus suis, Streptococcus suis serotype 2, and Glaesserella parasuis

Animal Research and One Health, Volume 2, Issue 1, Page 59-70, February 2024.
This article aims to establish a multiplex real‐time polymerase chain reaction (PCR) assay for the simultaneous detection of Streptococcus suis (SS), Streptococcus suis serotype 2 (SS2), and Glaesserella parasuis (GPS). In this study, three pairs of primers and three probes were designed based on the specific sequences of SS (gdh), SS2 (cps2j), and GPS
Lingxiang Xin, Haojie Wang, Yunhao Hu, Yan Liu, Wensheng Yao, Xiuli Wang, Jian Li, Yuanjie Liu, Rendong Tong, Qi Wang, Youlong Lu, Liangquan Zhu   +11 more
wiley   +1 more source

Veterinary bacteriology in Denmark from the 1880s to 2022

APMIS, Volume 132, Issue 1, Page 31-42, January 2024.
This paper gives an account of the history of veterinary bacteriology including clinical veterinary bacteriology as well as the area of veterinary public health in Denmark from the 1880s to 2022. We describe key persons, including B. Bang, C.O. Jensen, K.A.
Jørgen J. Leisner, Jens Laurits Larsen
wiley   +1 more source

Genetic and Pathogenic Characteristics of an Emerging Highly Virulent Recombinant Lineage Korean Clade C PRRSV Strain

Transboundary and Emerging Diseases, Volume 2024, Issue 1, 2024.
A strain of porcine reproductive and respiratory syndrome virus (PRRSV) was isolated from lung tissue of a pig showing severe respiratory clinical signs from a farm in Gyeongsang province of South Korea. This PRRSV strain, designated as SNUVR220803, was classified within the lineage Korean clade C (LKC) based on a phylogenetic analysis of the ORF5 gene.
Jeongmin Suh, Chanhee Chae, Nan-Hua Chen
wiley   +1 more source

A Protective Role of Canonical Wnt/β‐Catenin Pathway in Pathogenic Bacteria‐Induced Inflammatory Responses

Mediators of Inflammation, Volume 2024, Issue 1, 2024.
Inflammation is a complex host defensive response against various disease‐associated pathogens. A baseline extent of inflammation is supposed to be tightly associated with a sequence of immune‐modulated processes, resulting in the protection of the host organism against pathogen invasion; however, as a matter of fact is that an uncontrolled ...
Zhongjia Jiang, Weiping Zhou, Xing Tian, Peng Zou, Ning Li, Chunmeng Zhang, Yanting Li, Guangyan Liu, Sachchida Nand Rai   +8 more
wiley   +1 more source