Results 61 to 70 of about 1,719 (158)

Pigs Overexpressing Porcine β-Defensin 2 Display Increased Resilience to Glaesserella parasuis Infection

Antibiotics, 2020
As the causative agent of Glässer’s disease, Glaesserella (Haemophilus) parasuis has led to serious economic losses to the swine industry worldwide. Due to the low cross-protection of vaccines and increasing antimicrobial resistance of G. parasuis, it is
Jing Huang, Xiaoyu Yang, Antian Wang, Chao Huang, Hao Tang, Qiuhong Zhang, Qiong Fang, Zuming Yu, Xiao Liu, Qi Huang, Rui Zhou, Lu Li   +11 more
doaj   +1 more source

Phenotype‐Specific Semi‐Mechanistic Modelling of Florfenicol Time‐Kill Curves in G. Parasuis Compared to Other Respiratory Pathogens

Journal of Veterinary Pharmacology and Therapeutics, Volume 48, Issue 4, Page 318-339, July 2025.
ABSTRACT This study examines the pharmacodynamics (PD) of florfenicol (FFN) for treating porcine respiratory diseases by comparing its effects on Glaesserella parasuis, Actinobacillus pleuropneumoniae and Pasteurella multocida. In vitro time‐kill assays and semi‐mechanistic PD modeling were used to assess bacterial growth and killing rates at varying ...
Andrew Mead, Abigail Hughes, Stefano Azzariti, Pierre‐Louis Toutain, Ludovic Pelligand   +4 more
wiley   +1 more source

Molecular serotyping of clinical strains of Haemophilus (Glaesserella) parasuis brings new insights regarding Glässer’s disease outbreaks in Brazil [PDF]

PeerJ, 2019
Glässer’s disease (GD) is an important infectious disease of swine caused by Haemophilus (Glaesserella) parasuis. Vaccination with inactivated whole cell vaccines is the major approach for prevention of H.
Julia Pires Espíndola, Natalia Balbinott, Letícia Trevisan Gressler, Gustavo Machado, Catia Silene Klein, Raquel Rebelatto, César Bernardo Gutiérrez Martín, Luiz Carlos Kreutz, Anthony Bernard Schryvers, Rafael Frandoloso   +9 more
doaj   +2 more sources

Pharmacokinetic–Pharmacodynamic Cutoff Values for Doxycycline in Pigs to Support the Establishment of Clinical Breakpoints for Antimicrobial Susceptibility Testing

Journal of Veterinary Pharmacology and Therapeutics, Volume 48, Issue 4, Page 300-317, July 2025.
ABSTRACT This meta‐analysis provides a population model of doxycycline (DOXY) disposition in pigs for computation of PK/PD cutoff values corresponding to differing modalities of DOXY administration orally in pigs. This analysis enables establishment of specific clinical breakpoints for the development of antimicrobial susceptibility testing of DOXY in ...
Pierre‐Louis Toutain, Alain Bousquet‐Melou, Aude A. Ferran, Béatrice B. Roques, Jérôme R. E. del Castillo, Peter Lees, Siska Croubels, Eric Bousquet, Ludovic Pelligand   +8 more
wiley   +1 more source

Complete Genome Sequence of Haemophilus parasuis SH0165 [PDF]

Journal of Bacteriology, 2009
ABSTRACT Haemophilus parasuis is the causative agent of Glässer's disease, which produces big losses in swine populations worldwide. H. parasuis SH0165, belonging to the dominant serovar 5 in China, is a clinically isolated strain with high-level virulence.
Min, Yue, Fan, Yang, Jian, Yang, Weicheng, Bei, Xuwang, Cai, Lihong, Chen, Jie, Dong, Rui, Zhou, Meilin, Jin, Qi, Jin, Huanchun, Chen   +10 more
openaire   +2 more sources

Rational Design of Natural Xanthones Against Gram‐negative Bacteria

Advanced Science, Volume 12, Issue 14, April 10, 2025.
The skeletons are screened and obtained from natural xanthones to penetrate the outer membrane (OM) in Gram‐negative bacteria. The analog of α‐mangostin functionalized with amine groups crosses the OM through a self‐promoted pathway. The design and elucidation of antibacterial compounds crossing the OM facilitates the discovery of novel compounds ...
Xiaojia Liu, Meirong Song, Ying Liu, Shuyu Yang, Shang Chen, Jijun Kang, Jianzhong Shen, Kui Zhu   +7 more
wiley   +1 more source

The AI-2/luxS Quorum Sensing System Affects the Growth Characteristics, Biofilm Formation, and Virulence of Haemophilus parasuis

Frontiers in Cellular and Infection Microbiology, 2019
Haemophilus parasuis (H. parasuis) is a kind of opportunistic pathogen of the upper respiratory tract of piglets. Under certain circumstances, virulent strains can breach the mucosal barrier and enter the bloodstream, causing severe Glässer's disease ...
Bingzhou Zhang, Xugang Ku, Xiaoqian Zhang, Yan Zhang, Guo Chen, Fangzhou Chen, Wei Zeng, Jing Li, Ling Zhu, Qigai He   +9 more
doaj   +1 more source

Whole‐Genomic Characterization of Two Different PRRSV‐1 Strains Isolated From a Single Pig

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Recent studies have demonstrated that porcine reproductive and respiratory syndrome virus 1 (PRRSV‐1) strains isolated from different farms in China have significant genomic heterogeneity, whereas strains from the same farm present a high degree of genomic similarity.
Bangjun Gong, Jiahao Shi, Hu Xu, Chao Li, Lirun Xiang, Zhenyang Guo, Jinhao Li, Siyu Zhang, Zixuan Feng, Haonan Kang, Xueli Zhang, Ziyu Song, Qian Wang, Jinmei Peng, Guohui Zhou, Chaoliang Leng, Kuan Zhao, Yan-Dong Tang, Huairan Liu, Tong-Qing An, Xuehui Cai, Zhi-Jun Tian, Hongliang Zhang, Nan-hua Chen   +23 more
wiley   +1 more source

Pathogenicity and Immunity Studies of Haemophilus Parasuis Serotypes [PDF]

Acta Veterinaria Scandinavica, 1993
After intranasal inoculation of SPF pigs with the 7 reference strains of Haemophilus parasuis only the reference strains of serotypes 1 and 5 proved to be pathogenic and were able to produce the lesions characteristic of Glässer's disease. Even though the reference strains of serotypes 2, 3, 4, 6 and 7 proved to be apathogenic, intranasal inoculation ...
openaire   +2 more sources

Haemophilus parasuis cytolethal distending toxin induces cell cycle arrest and p53-dependent apoptosis.

PLoS ONE, 2017
Haemophilus parasuis is the causative agent of Glasser's disease in pigs. Cytolethal distending toxin (CDT) is an important virulence factor of H. parasuis.
Gang Li, Hui Niu, Yanhe Zhang, Yanling Li, Fang Xie, Paul R Langford, Siguo Liu, Chunlai Wang   +7 more
doaj   +1 more source