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Gating of hair cell Ca2+channels governs the activity of cochlear neurons
Karagulyan N +11 more
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Current Opinion in Neurobiology, 1993
Neurobiologists have been challenged by the desire to understand how the highly specialized ultrastructure of the sensory hair cells of the ear develops, how patterns of phenotypically distinct hair cells are formed and regenerate, and how their specific neural connections are formed.
J T, Corwin, M E, Warchol, M W, Kelley
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Neurobiologists have been challenged by the desire to understand how the highly specialized ultrastructure of the sensory hair cells of the ear develops, how patterns of phenotypically distinct hair cells are formed and regenerate, and how their specific neural connections are formed.
J T, Corwin, M E, Warchol, M W, Kelley
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Seminars in Cell & Developmental Biology, 2007
The increasing use of the hair follicle as a stem cell paradigm is due in part to the complex interplay between epithelial, dermal and other cell types, each with interesting differentiation potential and prospective therapeutic applications. This review focuses on research into the environmental niche, gene expression profiles and plasticity of hair ...
James M, Waters +2 more
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The increasing use of the hair follicle as a stem cell paradigm is due in part to the complex interplay between epithelial, dermal and other cell types, each with interesting differentiation potential and prospective therapeutic applications. This review focuses on research into the environmental niche, gene expression profiles and plasticity of hair ...
James M, Waters +2 more
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2019
Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In contrast, hair cells in nonmammalian vertebrates such as birds and in the zebrafish lateral line have the ability to regenerate after hair cell loss.
Yan, Chen +3 more
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Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In contrast, hair cells in nonmammalian vertebrates such as birds and in the zebrafish lateral line have the ability to regenerate after hair cell loss.
Yan, Chen +3 more
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Annals of Otology, Rhinology & Laryngology, 2000
The sensory hair cells of the inner ear are responsible for converting balance and hearing stimuli into electrical signals. Until recently, all previous studies of hair cell physiology had been performed on tissue obtained from non-mammals and rodents.
J S, Oghalai +7 more
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The sensory hair cells of the inner ear are responsible for converting balance and hearing stimuli into electrical signals. Until recently, all previous studies of hair cell physiology had been performed on tissue obtained from non-mammals and rodents.
J S, Oghalai +7 more
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How hair cells hear: the molecular basis of hair-cell mechanotransduction
Current Opinion in Otolaryngology & Head & Neck Surgery, 2008This review aims to summarize our current knowledge regarding mechanotransduction by hair cells and to highlight unresolved questions.Despite over a quarter of a century of electrophysiological data describing hair-cell mechanotransduction, the molecular basis of this process is just now being revealed.
Kelli R, Phillips +2 more
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Models of Hair Cell Mechanotransduction
2007Hair cell mechanotransduction is based on a finely tuned machinery residing in the hair bundle, the hair cell's receptive organelle. The machinery consists of a transduction channel, an adaptation motor, the tip link, and many other components that reside in the stereocilia.
Bechstedt, S., Howard, J.
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Annual Review of Neuroscience, 2000
Hair cells adapt to sustained deflections of the hair bundle via Ca2+dependent negative feedback on the open probability of the mechanosensitive transduction channels. A model posits that adaptation relieves the input to the transduction channels—force applied by elastic tip links between stereocilia—by repositioning the insertions of the links in the
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Hair cells adapt to sustained deflections of the hair bundle via Ca2+dependent negative feedback on the open probability of the mechanosensitive transduction channels. A model posits that adaptation relieves the input to the transduction channels—force applied by elastic tip links between stereocilia—by repositioning the insertions of the links in the
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The Electrophysiology of Hair Cells
Annual Review of Physiology, 1991Both the hearing and vestibular organs of vertebrates contain cells responsive to miniscule mechanical disturbances. The common element is the hair cell, a sensory cell with a specialized mechanoreceptor at its apical end and with a basolateral membrane designed to shape the receptor potential and control synaptic interaction at its basal pole. The way
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International Congress Series, 2003
Abstract Hair cell loss is usually a function of age, noise, ototoxic drugs and genetics. Therapeutic strategies fall into two categories: protection and regeneration. Protective methods include targeted application of growth factors and other agents to promote cell survival, and systemic application of drugs to prevent activation of programmed cell ...
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Abstract Hair cell loss is usually a function of age, noise, ototoxic drugs and genetics. Therapeutic strategies fall into two categories: protection and regeneration. Protective methods include targeted application of growth factors and other agents to promote cell survival, and systemic application of drugs to prevent activation of programmed cell ...
openaire +1 more source