Results 241 to 250 of about 543,428 (303)

Regulation of cochlear hair cell function by intracellular calcium stores. [PDF]

Front Cell Neurosci
Sinha GP, Frolenkov GI.
europepmc   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Developmental plasticity facilitates the structural maturation of cochlear inner hair cell ribbon synapses

Voorn RA, Sternbach M, Bourien J, Komiyama NH, Rankovič V, Wolf F, Grant SGN, Vogl C.   +7 more
europepmc   +1 more source

Functional, sustained recovery of hearing in Otoferlin-deficient mice using DB-OTO, a hair-cell-specific AAV-based gene therapy. [PDF]

Mol Ther Methods Clin Dev
Chung Y, Koehler SD, Cancelarich S, Gibson TM, Pregernig G, Becker L, Artinian QA, Goodliffe JW, Pan N, Quigley TM, Senapati A, Slade PG, Smith LM, So KS, Zhang X, Corrales CE, Weber P, Macdonald LE, Zambrowicz B, Economides AN, Kyratsous CA, Burns JC, Palermo AT, Sabin LR, Lee J, Valayannopoulos V, Whitton JP, Drummond MC.   +27 more
europepmc   +1 more source

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Correction to "AAV-Mediated Gene Cocktails Enhance Supporting Cell Reprogramming and Hair Cell Regeneration". [PDF]

Adv Sci (Weinh)
Zhang L, Chen X, Wang X, Zhou Y, Fang Y, Gu X, Zhang Z, Sun Q, Li N, Xu L, Tan F, Chai R, Qi J.   +12 more
europepmc   +1 more source

Structural insights into calcium-dependent CIB2-TMC1 interaction in hair cell mechanotransduction. [PDF]

Commun Biol
Li Y, Chen J, Jiang W, Ye J, Zhang X, Wang C.   +5 more
europepmc   +1 more source

Functional and Structural Changes in the Inner Ear and Cochlear Hair Cell Loss Induced by Hypergravity. [PDF]

Int J Mol Sci
Choi JS, Kim KS, Kim HJ.
europepmc   +1 more source

Bridging the gap between presynaptic hair cell function and neural sound encoding. [PDF]

Elife
Jaime Tobón LM, Moser T.
europepmc   +1 more source

Inhibition of the cGAS‑STING Pathway Reduces Cisplatin-Induced Inner Ear Hair Cell Damage. [PDF]

Neurosci Bull
Sun Y, Zou S, Xu X, Xu S, Sun H, Tang M, Kong W, Chen X, He Z.   +8 more
europepmc   +1 more source