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How hair cells hear: the molecular basis of hair-cell mechanotransduction
Current Opinion in Otolaryngology & Head & Neck Surgery, 2008This review aims to summarize our current knowledge regarding mechanotransduction by hair cells and to highlight unresolved questions.Despite over a quarter of a century of electrophysiological data describing hair-cell mechanotransduction, the molecular basis of this process is just now being revealed.
Kelli R, Phillips +2 more
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The Electrophysiology of Hair Cells
Annual Review of Physiology, 1991Both the hearing and vestibular organs of vertebrates contain cells responsive to miniscule mechanical disturbances. The common element is the hair cell, a sensory cell with a specialized mechanoreceptor at its apical end and with a basolateral membrane designed to shape the receptor potential and control synaptic interaction at its basal pole. The way
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Models of Hair Cell Mechanotransduction
2007Hair cell mechanotransduction is based on a finely tuned machinery residing in the hair bundle, the hair cell's receptive organelle. The machinery consists of a transduction channel, an adaptation motor, the tip link, and many other components that reside in the stereocilia.
Bechstedt, S., Howard, J.
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Annual Review of Neuroscience, 2000
Hair cells adapt to sustained deflections of the hair bundle via Ca2+dependent negative feedback on the open probability of the mechanosensitive transduction channels. A model posits that adaptation relieves the input to the transduction channels—force applied by elastic tip links between stereocilia—by repositioning the insertions of the links in the
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Hair cells adapt to sustained deflections of the hair bundle via Ca2+dependent negative feedback on the open probability of the mechanosensitive transduction channels. A model posits that adaptation relieves the input to the transduction channels—force applied by elastic tip links between stereocilia—by repositioning the insertions of the links in the
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MECHANISMS OF HAIR CELL TUNING
Annual Review of Physiology, 1999▪ Abstract Mechanosensory hair cells of the vertebrate inner ear contribute to acoustic tuning through feedback processes involving voltage-gated channels in the basolateral membrane and mechanotransduction channels in the apical hair bundle. The specific number and kinetics of calcium-activated (BK) potassium channels determine the resonant ...
R, Fettiplace, P A, Fuchs
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Vesicle Targeting in Hair Cells
Audiology and Neurotology, 2002The mammalian hair cell has two distinct plasma membrane domains separated by tight junctions, the apical domain which contains the stereocilia and the basolateral domain which contains the presynaptic region. Little is known concerning the mechanisms that regulate vesicle trafficking to these two domains.
Robert J, Wenthold +7 more
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Hearing Research, 1990
This study assessed the contribution of the apical hair cells to hearing. Guinea pigs, chinchillas and monkeys were behaviorally trained using positive reinforcement to respond to pure-tone stimuli. When a stable audiogram had been determined, each subject received one of three experimental treatments: ototoxic drug administration, low-frequency noise ...
Prosen, Cynthia A. +7 more
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This study assessed the contribution of the apical hair cells to hearing. Guinea pigs, chinchillas and monkeys were behaviorally trained using positive reinforcement to respond to pure-tone stimuli. When a stable audiogram had been determined, each subject received one of three experimental treatments: ototoxic drug administration, low-frequency noise ...
Prosen, Cynthia A. +7 more
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Seminars in Cell & Developmental Biology, 2007
The increasing use of the hair follicle as a stem cell paradigm is due in part to the complex interplay between epithelial, dermal and other cell types, each with interesting differentiation potential and prospective therapeutic applications. This review focuses on research into the environmental niche, gene expression profiles and plasticity of hair ...
James M, Waters +2 more
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The increasing use of the hair follicle as a stem cell paradigm is due in part to the complex interplay between epithelial, dermal and other cell types, each with interesting differentiation potential and prospective therapeutic applications. This review focuses on research into the environmental niche, gene expression profiles and plasticity of hair ...
James M, Waters +2 more
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Immunolocalization of myosin Iβ in the hair cell's hair bundle
Cell Motility and the Cytoskeleton, 1998The hair bundle, the hair cell's sensory organelle, transduces acoustical or vestibular stimulation into a change in membrane potential. The actin-based stereociliary processes of the hair bundle contain a number of myosin isoforms that may be important to the bundle's function.
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Mechanoelectrical Transduction by Hair Cells
Annual Review of Biophysics and Biophysical Chemistry, 1988STRUCTURE AND STIMULATION OF THE HAIR BUNDLE 100 Structure of the Hair Bundle.... ......... .. . . . .... . . . . . . . . . . . . . . . . . . . . . .. . . . . . 100 Mechanical Properties of the Hair Bundle ....... ......... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
J, Howard, W M, Roberts, A J, Hudspeth
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