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Cholinergic Inhibition of Hair Cells
2010In the inner ear, the activity of hair cells that transform sound into electrical signals is modulated by a descending efferent innervation from the brain. A major component of this feedback involves cholinergic inhibition of hair cells via an unusual ionic mechanism. It activates rapidly (on the order of milliseconds), but instead of being mediated by
Katz, Eleonora +2 more
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Functional Development of Hair Cells
2003Abstract Embryonic hair cells in chicks and mammals have functional transduction channels and voltage-gated outwardly rectifying potassium (K + ) channels, fast inwardly rectifying channels, and voltage-gated sodium (Na + ) and calcium (Ca 2+ ) channels.
Ruth Anne, Eatock, Karen M, Hurley
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Development and regeneration of hair cells
Acta Oto-Laryngologica, 2007The vertebrate inner ear is derived from the otic placode and undergoes a complicated series of morphogenetic processes to differentiate into an elaborate structure harboring mechanosensory epithelia featuring hair cells, the mechanoreceptors of hearing and balance.
Ozeki, Hidenori +4 more
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Hair Cells – Beyond the Transducer
Journal of Membrane Biology, 2006This review considers the "tween twixt and twain" of hair cell physiology, specifically the signaling elements and membrane conductances which underpin forward and reverse transduction at the input stage of hair cell function and neurotransmitter release at the output stage. Other sections of this review series outline the advances which have been made
G D, Housley +3 more
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A study of the medullary cells of the hair
Experimental Cell Research, 1953Abstract 1. 1. Medullary cells of white rabbit hair were isolated by a modified method of Lloyd and Marriott. 2. 2. Microscopic examination of isolated medullary cells shows that they are made up of both large and small granules. Medullary cells appear isotropic under the polarizing microscope.
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Mechanoelectrical transduction by hair cells
Trends in Neurosciences, 1992Hair cells of the inner ear are one of nature's great success stories, appearing early in vertebrate evolution and having a similar form in all vertebrate classes. They are specialized columnar epithelial cells, with an array of modified microvilli or stereocilia on their apical surface, interconnected by a series of linkages.
J O, Pickles, D P, Corey
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The hair cell's transduction channel
Current Opinion in Neurobiology, 2002The elusive transduction channel is the key player in mechanical transduction by the sensory hair cells of the inner ear. Multiple factors have thwarted molecular identification of this channel, including the lack of a definitive pharmacological signature, the paucity of hair cells, and the uniqueness of their transduction mechanism. At present, we are
Meredith, Strassmaier +1 more
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The aging vestibular hair cell
American Journal of Otolaryngology, 1983The ultrastructure of aging vestibular hair cells of the guinea pig can be abnormal even though they appear morphologically normal by light microscopy. In only a few of the hair cells studied did nonspecific changes occur. In general, the age-related changes involved specific structures in the hair cells: aggregations of lipofuscin pigments ...
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Cytodifferentiation of cochlear hair cells
American Journal of Otolaryngology, 1983Cytodifferentiation of a limited number of cochlear hair cells in the mouse starts on the 14th gestational day. One day later, the number of identified hair cells increases considerably. Cytodifferentiation apparently occurs in a gradient from the hair cell surface to the base.
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