Results 41 to 50 of about 13,036 (186)

Auditory sensitivity and the outer hair cell system in the CBA mouse model of age-related hearing loss

Open Access Animal Physiology, 2010
Age-related hearing loss is a highly prevalent sensory disorder, from both the clinical and animal model perspectives. Understanding of the neurophysiologic, structural, and molecular biologic bases of age-related hearing loss will facilitate development of biomedical therapeutic interventions to prevent, slow, or reverse its progression.
Frisina,Robert, Zhu,Xiaoxia
openaire   +4 more sources

The Effects of Urethane on Rat Outer Hair Cells [PDF]

, 2016
The cochlea converts sound vibration into electrical impulses and amplifies the low-level sound signal. Urethane, a widely used anesthetic in animal research, has been shown to reduce the neural responses to auditory stimuli.
Xueying Yang, Mengzi Chen, Xiao Yan, Jinfang Xiao, Jie Tang, Mingyu Fu   +5 more
core   +1 more source

Progress On Sensorineural Hearing Loss: Mechanisms and Therapies

Sensory Neuroscience, EarlyView.
ABSTRACT Hearing loss is the most common disabling disease among humans, which adversely affects human health. Sensorineural hearing loss (SNHL) accounting for approximately 63% of all hearing loss cases. SNHL may be classified into age‐related hearing loss (ARHL), drug‐induced hearing loss (DIHL), noise‐induced hearing loss (NIHL), and sudden ...
Yuan Zhang, Shen Li, Yangfan Zhou, Duopin Li, Junru Ding, Ruifeng Qiao, Yutian Chen, Fanglei Ye, Le Wang, Peipei Li   +9 more
wiley   +1 more source

AMPKα Silencing Prevents Kanamycin‐Induced Ototoxicity in an Acute Mouse Model

Sensory Neuroscience, EarlyView.
Kanamycin plus furosemide (KM + FU) treatment (acute ototoxic model) causes AMPKα activation and rapidly induces cochlear outer hair cell (OHC) loss. Silencing AMPKα1 via posterior semicircular canal injection 48 h before KM + FU treatment reduces this damage, preserving OHCs and hearing.
Shengyu Zou, Fan Wu, Qiaojun Fang, Zuhong He, Hongguo Su, Shan Xu, Su‐Hua Sha   +6 more
wiley   +1 more source

Too much of a good thing: Long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity [PDF]

Hearing Research, 2010
Aspirin has been extensively used in clinical settings. Its side effects on auditory function, including hearing loss and tinnitus, are considered as temporary. A recent promising finding is that chronic treatment with high-dose salicylate (the active ingredient of aspirin) for several weeks enhances expression of the outer hair cell (OHC) motor ...
Chen, Guang Di, Kermany, Mohammad Habiby, D'Elia, Alessandra, RALLI, MASSIMO, Tanaka, Chiemi, Bielefeld, Eric C., Ding, Dalian, Henderson, Donald, Salvi, Richard   +8 more
openaire   +3 more sources

A Dominantly Inherited Progressive Deafness Affecting Distal Auditory Nerve and Hair Cells [PDF]

, 2004
We have studied 72 members belonging to a large kindred with a hearing disorder inherited in an autosomal dominant pattern. We used audiological, physiological, and psychoacoustic measures to characterize the hearing disorders.
Paulson, George W., Paulson, George W, Keats, Bronya J. B., Lesperance, Marci M, Keats, Bronya JB, Lesperance, Marci M., Starr, Arnold, Isaacson, Brandon, Zeng, Fan-Gang, Kong, Ying-Yee, Beale, Paula, Michalewski, Henry J., Michalewski, Henry J   +12 more
core   +1 more source

Epac1 Alleviates Senescence in Auditory Hair Cells via the Ferroptosis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives The aim of this study was to investigate the changes in Epac1 and ferroptosis‐related proteins in aged mice and the House Ear Institute‐Organ of Corti 1 (HEI‐OC1) cells, with the goal of elucidating their potential role in age‐related hearing loss. Methods The expression of Epac1 in the cochlea of C57BL/6J mice was examined by using
Wen‐Jun An, Chen‐Yu Xu, Meng‐Ya Shen, Xiao‐Tao Guo, Chun‐Chen Pan, Jing‐Wu Sun, Xiao‐Min Tang, Jia‐Qiang Sun   +7 more
wiley   +1 more source

Epidermal Growth Factor Receptor substrate 8 (Eps8) controls Src/FAK-dependent phenotypes in squamous carcinoma cells [PDF]

, 2014
Eps8 is an actin regulatory scaffold protein increased in Squamous Cell Carcinoma (SCC) cells. It forms a complex with both Focal Adhesion Kinase (FAK) and c-Src in SCC cells derived from the DMBA/TPA model of skin carcinogenesis.
Schoenherr, Christina, Baillie, George S., Frame, Margaret, Heath, John K., Proby, Charlotte, Frame, Margaret C., Cunningham, Debbie L, Findlay, Jane E, Cunningham, Debbie L., Findlay, Jane E., Baillie, George S, Heath, John K, Serrels, Bryan, Frame, Margaret C   +13 more
core   +1 more source

An Experimental Study on the Protective Effect of Memantine in Noise‐Induced Hearing Loss

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Begüm Arda, Selis Gülseven Güven, Erdoğan Bulut, Murat Arslan, Özlem Tuğce Çilingir‐Kaya, Abdullah Taş, Recep Yağız   +6 more
wiley   +1 more source

Postmortem submergence interval (PMSI) and human decomposition in anthropogenically constructed aqueous environments (pools, bathtubs, hot tubs, and spas)

Journal of Forensic Sciences, EarlyView.
Abstract Postmortem decomposition changes of bodies in aquatic environments may offer valuable insights into the postmortem submergence interval (PMSI) for medicolegal death investigators. However, the effects of immersion on the onset of such changes are poorly understood.
Vienna C. Lam, Gail S. Anderson, Melanie S. Archer, Gemma C. Dickson, Samantha K. Rowbotham   +4 more
wiley   +1 more source