Results 61 to 70 of about 13,036 (186)
, 2010 Hair cells are the mechanosensory cells of the inner ear whose loss causes irreversible hearing loss in mammals. POU4F3, a POU-domain transcription factor, is only expressed in hair cells in the inner ear and is essential for hair cell terminal ...
Tornari, C.
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Mesna in Otologic Surgery: Efficacy and Safety—A Scoping Review
The Laryngoscope, Volume 136, Issue 6, Page 2449-2460, June 2026.PRISMA flow diagram indicating the process of systematic inclusion and exclusion of articles. ABSTRACT Objective Mesna (Sodium 2‐mercaptoethanesulfonate) is widely used as a mucolytic agent and uroprotective agent. Recently, its disulfide bond‐breaking property has been applied in otologic surgery to facilitate safer dissection of cholesteatoma and ...
Kevork H. Atamian +4 more
wiley +1 more source
Static length changes of cochlear outer hair cells can tune low-frequency hearing
, 2017 The cochlea not only transduces sound-induced vibration into neural spikes, it also amplifies weak sound to boost its detection. Actuators of this active process are sensory outer hair cells in the organ of Corti, whereas the inner hair cells transduce ...
Anders Fridberger +5 more
core +1 more source
Organoids: From Bench to Bedside Applications
MedComm, Volume 7, Issue 6, June 2026.Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li +6 more
wiley +1 more source
, 2008 The spontaneous mutant circling mouse (cir/cir) shows a circling behavior and hearing loss. We produced transgenic mice overexpressing the causative gene, transmembrane inner ear (tmie), for the phenotypic rescue of the circling mouse.
Mi Jung Shin +13 more
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Improved Bone Conduction and Hearing Outcomes After Stapes Surgery for Otosclerosis
World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 3, Page 298-304, June 2026.ABSTRACT Objective To evaluate the improvement in bone conduction (BC) thresholds after stapes surgery for otosclerosis, compare the outcomes of surgical techniques, and analyze the short‐ and long‐term results to inform treatment strategies. Methods We retrospectively reviewed data from 173 patients (188 ears) who underwent total stapedectomy, partial
Na Zhang +6 more
wiley +1 more source
Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea
, 2006 Gap junctional intercellular communication (GJIC) plays a major role in cochlear function. Recent evidence suggests that connexin 26 (Cx26) and Cx30 are the major constituent proteins of cochlear gap junction channels, possibly in a unique heteromeric ...
Jagger, DJ, Forge, A
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Journal of the Association for Research in OtolaryngologyAbstract Purpose Although human temporal bones suggest that cochlear synapse numbers decline with age and noise exposure, no validated diagnostic method exists. In animal models, cochlear synaptopathy is associated with reduced auditory brainstem response (ABR) wave 1 amplitude and envelope ...
Brad N. Buran +4 more
openaire +3 more sources
Damage-induced signalling mechanisms in the neonatal rat cochlea.
, 2007 Sound overstimulation and exposure to ototoxic drugs damage cochlear hair cells (HCs) and cause their death. The surrounding support cells maintain an epithelial barrier and the appropriate physiological environment for surviving HCs during pathological ...
Lahne, M.
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CTCF is required for maintenance of auditory hair cells and hearing function in the mouse cochlea.
, 2018 Auditory hair cells play an essential role in hearing. These cells convert sound waves, mechanical stimuli, into electrical signals that are conveyed to the brain via spiral ganglion neurons.
복진웅 +3 more
core +1 more source