Results 11 to 20 of about 10,895,649 (358)
Transcriptomic characterization of dying hair cells in the avian cochlea
Cell Reports, 2021 Summary: Sensory hair cells are prone to apoptosis caused by various drugs including aminoglycoside antibiotics. In mammals, this vulnerability results in permanent hearing loss because lost hair cells are not regenerated.
Nesrine Benkafadar +5 more
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Apicosome: Newly identified cell-type-specific organelle in mouse cochlear and vestibular hair cells
iScience, 2023 Summary: Cochlear and vestibular hair cells are highly specialized sensory receptors for hearing and balance. Here, we report a serendipitous identification of a hair-cell-specific organelle in neonatal mouse inner ear, which we name “apicosome.” The ...
Xiaofen Li +9 more
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Current Opinion in Neurobiology, 2008 The mammalian inner ear largely lacks the capacity to regenerate hair cells, the sensory cells required for hearing and balance. Recent studies in both lower vertebrates and mammals have uncovered genes and pathways important in hair cell development and have suggested ways that the sensory epithelia could be manipulated to achieve hair cell ...
Zheng-Yi Chen +2 more
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Notch signaling limits supporting cell plasticity in the hair cell-damaged early postnatal murine cochlea. [PDF]
PLoS ONE, 2013 In mammals, auditory hair cells are generated only during embryonic development and loss or damage to hair cells is permanent. However, in non-mammalian vertebrate species, such as birds, neighboring glia-like supporting cells regenerate auditory hair ...
Soumya Korrapati +3 more
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Hair Follicle Stem Cells [PDF]
Journal of Investigative Dermatology Symposium Proceedings, 2003 The workshop on Hair Follicle Stem Cells brought together investigators who have used a variety of approaches to try to understand the biology of follicular epithelial stem cells, and the role that these cells play in regulating the hair cycle.
Lavker, Robert M +11 more
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Efferent control of the electrical and mechanical properties of hair cells in the bullfrog's sacculus. [PDF]
PLoS ONE, 2010 Hair cells in the auditory, vestibular, and lateral-line systems respond to mechanical stimulation and transmit information to afferent nerve fibers. The sensitivity of mechanoelectrical transduction is modulated by the efferent pathway, whose activity ...
Manuel Castellano-Muñoz +2 more
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eLife, 2022 Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1 has been proposed as a potential therapeutic strategy for hearing loss.
Amrita A Iyer +15 more
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Myosin and Adaptation by Hair Cells [PDF]
Neuron, 1997 Conclusive identification of the adaptation motor is not entirely academic. For example, a rational approach to identifying other members of the transduction apparatus is first to identify one component—the adaptation motor seems most likely—and then to identify interacting proteins using biochemical and molecular biological methods.
Peter G. Gillespie, David P. Corey
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The Transcriptomics to Proteomics of Hair Cell Regeneration: Looking for a Hair Cell in a Haystack [PDF]
Microarrays, 2013 Mature mammals exhibit very limited capacity for regeneration of auditory hair cells, while all non-mammalian vertebrates examined can regenerate them. In an effort to find therapeutic targets for deafness and balance disorders, scientists have examined gene expression patterns in auditory tissues under different developmental and experimental ...
Michael E. Smith, Gopinath Rajadinakaran
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Signaling pathways in hair aging
Frontiers in Cell and Developmental Biology, 2023 Hair follicle (HF) homeostasis is regulated by various signaling pathways. Disruption of such homeostasis leads to HF disorders, such as alopecia, pigment loss, and hair aging, which is causing severe health problems and aesthetic concerns.
Aishi Liang +6 more
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