Results 11 to 20 of about 10,997,299 (381)
Lgr5-Positive Supporting Cells Generate New Hair Cells in the Postnatal Cochlea [PDF]
Stem Cell Reports, 2014 The prevalence of hearing loss after damage to the mammalian cochlea has been thought to be due to a lack of spontaneous regeneration of hair cells, the primary receptor cells for sound.
Naomi F. Bramhall +4 more
doaj +4 more sources
Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells [PDF]
Cell Reports, 2017 Death of cochlear hair cells, which do not regenerate, is a cause of hearing loss in a high percentage of the population. Currently, no approach exists to obtain large numbers of cochlear hair cells.
Will J. McLean +7 more
doaj +4 more sources
Hair cell damage recruited Lgr5-expressing cells are hair cell progenitors in neonatal mouse utricle [PDF]
Frontiers in Cellular Neuroscience, 2015 Damage-activated stem/progenitor cells play important roles in regenerating lost cells and in tissue repair. Previous studies reported that the mouse utricle has limited hair cell regeneration ability after hair cell ablation.
Jinchao eLin +3 more
doaj +4 more sources
Calcium entry into stereocilia drives adaptation of the mechanoelectrical transducer current of mammalian cochlear hair cells [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2014 Mechanotransduction in the auditory and vestibular systems depends on mechanosensitive ion channels in the stereociliary bundles that project from the apical surface of the sensory hair cells.
Laura F. Corns +3 more
semanticscholar +3 more sources
eLife, 2022 Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1 has been proposed as a potential therapeutic strategy for hearing loss.
Amrita A Iyer +15 more
doaj +1 more source
Myosin and Adaptation by Hair Cells [PDF]
Neuron, 1997 Conclusive identification of the adaptation motor is not entirely academic. For example, a rational approach to identifying other members of the transduction apparatus is first to identify one component—the adaptation motor seems most likely—and then to identify interacting proteins using biochemical and molecular biological methods.
Peter G. Gillespie, David P. Corey
openaire +3 more sources
Hair Follicle Stem Cells [PDF]
Journal of Investigative Dermatology Symposium Proceedings, 2003 The workshop on Hair Follicle Stem Cells brought together investigators who have used a variety of approaches to try to understand the biology of follicular epithelial stem cells, and the role that these cells play in regulating the hair cycle.
Lavker, Robert M +11 more
openaire +4 more sources
The Transcriptomics to Proteomics of Hair Cell Regeneration: Looking for a Hair Cell in a Haystack [PDF]
Microarrays, 2013 Mature mammals exhibit very limited capacity for regeneration of auditory hair cells, while all non-mammalian vertebrates examined can regenerate them. In an effort to find therapeutic targets for deafness and balance disorders, scientists have examined gene expression patterns in auditory tissues under different developmental and experimental ...
Michael E. Smith, Gopinath Rajadinakaran
openaire +3 more sources
Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea [PDF]
, 2020 Sound amplification within the mammalian cochlea depends upon specialized hair cells, the outer hair cells (OHCs), which possess both sensory and motile capabilities.
Ceriani, Federico +7 more
core +2 more sources
Signaling pathways in hair aging
Frontiers in Cell and Developmental Biology, 2023 Hair follicle (HF) homeostasis is regulated by various signaling pathways. Disruption of such homeostasis leads to HF disorders, such as alopecia, pigment loss, and hair aging, which is causing severe health problems and aesthetic concerns.
Aishi Liang +6 more
doaj +1 more source