Results 41 to 50 of about 227,838 (314)
Characterization of the Usher Syndrome gene CDH23: implications for mechanosensation in the vertebrate inner ear [PDF]
, 2004 Deafness is the most common form of sensory impairment afflicting the human population. Approximately one in eight hundred children is born with serious hearing impairment and more than half of these cases are likely due to single gene defects.
Siemens, Jan-Erik
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Outer Hair Cells and Electromotility [PDF]
Cold Spring Harbor Perspectives in Medicine, 2018 Outer hair cells (OHCs) of the mammalian cochlea behave like actuators: they feed energy into the cochlear partition and determine the overall mechanics of hearing. They do this by generating voltage-dependent axial forces. The resulting change in the cell length, observed by microscopy, has been termed "electromotility." The mechanism of force ...
openaire +3 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
The in vitro plasticity of hair follicle dermal and mesenchymal stem cells [PDF]
, 2008 Stem cells from the hair follicle are an easily accessible population of cells that have a broad in vitro developmental capabilities and potential for autologous replacement of damaged adult tissue.
Emmerson, Robert
core
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival?
PLoS ONE, 2016 Cochlear hair cells and the stria vascularis are critical for normal hearing. Hair cells transduce mechanical stimuli into electrical signals, whereas the stria is responsible for generating the endocochlear potential (EP), which is the driving force for
Huizhan Liu +8 more
doaj +1 more source
Hair cell ribbon synapses [PDF]
Cell and Tissue Research, 2006 Hearing and balance rely on the faithful synaptic coding of mechanical input by the auditory and vestibular hair cells of the inner ear. Mechanical deflection of their stereocilia causes the opening of mechanosensitive channels, resulting in hair cell depolarization, which controls the release of glutamate at ribbon-type synapses.
Tobias, Moser +2 more
openaire +2 more sources
Hair follicle germinative epidermal cells: a molecular study [PDF]
, 1999 At the base of the hair follicle epidermal matrix is a population of germinative epidermal (GE) cells that is in close communication with the dermal papilla.
Whitehouse, C.J. +1 more
core