Results 21 to 30 of about 10,895,649 (358)
RIM-Binding Proteins Are Required for Normal Sound-Encoding at Afferent Inner Hair Cell Synapses
Frontiers in Molecular Neuroscience, 2021 The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time.
Stefanie Krinner +10 more
doaj +1 more source
Beyond generalized hair cells: Molecular cues for hair cell types [PDF]
Hearing Research, 2013 Basic helix-loop-helix (bHLH) transcription factors (TFs) are crucial for inner ear neurosensory development. The proneural TF Atoh1 regulates the differentiation of hair cells (HCs) whereas Neurog1 and Neurod1 regulate specification and differentiation of neurons, respectively, but also affect HC development.
Israt Jahan +3 more
openaire +3 more sources
Stepwise fate conversion of supporting cells to sensory hair cells in the chick auditory epithelium
iScience, 2023 Summary: In contrast to mammals, the avian cochlea, specifically the basilar papilla, can regenerate sensory hair cells, which involves fate conversion of supporting cells to hair cells. To determine the mechanisms for converting supporting cells to hair
Mami Matsunaga +7 more
doaj +1 more source
eLife, 2023 A major cause of human deafness and vestibular dysfunction is permanent loss of the mechanosensory hair cells of the inner ear. In non-mammalian vertebrates such as zebrafish, regeneration of missing hair cells can occur throughout life.
Tuo Shi +7 more
doaj +1 more source
Renewed proliferation in adult mouse cochlea and regeneration of hair cells
Nature Communications, 2019 The adult mammalian inner ear lacks the capacity to divide or regenerate. Damage to inner ear generally leads to permanent hearing loss in humans. Here, we present that reprogramming of the adult inner ear induces renewed proliferation and regeneration ...
Y. Shu +12 more
semanticscholar +1 more source
Lgr5-Positive Supporting Cells Generate New Hair Cells in the Postnatal Cochlea
Stem Cell Reports, 2014 The prevalence of hearing loss after damage to the mammalian cochlea has been thought to be due to a lack of spontaneous regeneration of hair cells, the primary receptor cells for sound.
Naomi F. Bramhall +4 more
doaj +1 more source
Survival of auditory hair cells [PDF]
Cell and Tissue Research, 2015 The inability of mammals to regenerate auditory hair cells creates a pressing need to understand the means of enhancing hair cell survival following insult or injury. Hair cells are easily damaged by noise exposure, by ototoxic medications and as a consequence of aging processes, all of which lead to progressive and permanent hearing impairment as hair
Michelle L. Seymour, Fred A. Pereira
openaire +3 more sources
Generation of inner ear organoids with functional hair cells from human pluripotent stem cells
Nature Biotechnology, 2017 The derivation of human inner ear tissue from pluripotent stem cells would enable in vitro screening of drug candidates for the treatment of hearing and balance dysfunction and may provide a source of cells for cell-based therapies of the inner ear. Here
Karl R. Koehler +6 more
semanticscholar +1 more source
Hair follicle germs containing vascular endothelial cells for hair regenerative medicine
Scientific Reports, 2021 Hair regenerative medicine has emerged as a promising approach for the treatment of severe hair loss. Recent advances in three-dimensional tissue engineering, such as formation of hair follicle germs (HFGs), have considerably improved hair regeneration ...
Tatsuto Kageyama +2 more
doaj +1 more source
Sensory Hair Cells: An Introduction to Structure and Physiology.
Integrative and Comparative Biology, 2018 Sensory hair cells are specialized secondary sensory cells that mediate our senses of hearing, balance, linear acceleration, and angular acceleration (head rotation).
D. McPherson
semanticscholar +1 more source