Results 11 to 20 of about 5,127,301 (263)

Approaches of auditory hair cells induction from stem cells [PDF]

Otorhinolaryngology and Facial Plastic Surgery, 2017
Hair cells are the sensory epithelial cells of both the auditory and the vestibular systems in the inner ear of all vertebrates. Auditory hair cells are located in the organ of corti on a thin layer of basement membrane in the cochlea of the inner ear ...
Shahrokh Khoshsirat, Navid Ahmady Roozbahany, Somayeh Niknazar   +2 more
doaj   +2 more sources

Mutations in ap1b1 Cause Mistargeting of the Na(+)/K(+)-ATPase Pump in Sensory Hair Cells. [PDF]

, 2013
The hair cells of the inner ear are polarized epithelial cells with a specialized structure at the apical surface, the mechanosensitive hair bundle.
Kindt, Katie, Nicolson, T., Kindt, K., Katie Kindt, Teresa Nicolson, Schmid, Bettina, Bettina Schmid, Grisham, R., Finger-Baier, Karin, Clemens Grisham, Rachel, Rachel Clemens Grisham, Nicolson, Teresa, Schmid, B., Karin Finger-Baier, Finger-Baier, K.   +14 more
core   +2 more sources

Lgr5-Positive Supporting Cells Generate New Hair Cells in the Postnatal Cochlea

Stem Cell Reports, 2014
The prevalence of hearing loss after damage to the mammalian cochlea has been thought to be due to a lack of spontaneous regeneration of hair cells, the primary receptor cells for sound.
Naomi F. Bramhall, Fuxin Shi, Katrin Arnold, Konrad Hochedlinger, Albert S.B. Edge   +4 more
doaj   +1 more source

The organization of tip links and stereocilia on hair cells of bird and lizard basilar papillae [PDF]

, 1989
Auditory papillae from three species of bird (pigeon, starling, and chick), and two species of European lizard (Podarcis murolis and Podarcis sic&) were examined by scanning electron microscopy.
Pickles, J. O., Gleich, O., Brix, J., Gleich, Otto, Comis, S. D., Osborne, M. P., Köppl, C., Manley, G. A.   +7 more
core   +1 more source

Hair follicle germs containing vascular endothelial cells for hair regenerative medicine

Scientific Reports, 2021
Hair regenerative medicine has emerged as a promising approach for the treatment of severe hair loss. Recent advances in three-dimensional tissue engineering, such as formation of hair follicle germs (HFGs), have considerably improved hair regeneration ...
Tatsuto Kageyama, Yang-Sook Chun, Junji Fukuda   +2 more
doaj   +1 more source

Differentiation and transplantation of human induced pluripotent stem cell-derived otic epithelial progenitors in mouse cochlea

Stem Cell Research & Therapy, 2018
Background Inner ear hair cells as mechanoreceptors are extremely important for hearing. Defects in hair cells are a major cause of deafness. Induced pluripotent stem cells (iPSCs) are promising for regenerating inner ear hair cells and treating hearing ...
Jianling Chen, Fanfan Hong, Cui Zhang, Liang Li, Cuicui Wang, Haosong Shi, Yong Fu, Jinfu Wang   +7 more
doaj   +1 more source

Characterizing human vestibular sensory epithelia for experimental studies: new hair bundles on old tissue and implications for therapeutic interventions in ageing. [PDF]

, 2015
Balance disequilibrium is a significant contributor to falls in the elderly. The most common cause of balance dysfunction is loss of sensory cells from the vestibular sensory epithelia of the inner ear.
Daniel J. Jagger, Moffatt, D, Jagger, DJ, Peter Monksfield, Donnelly, N, Lloyd, SK, Irving, R, Coulson, C, Freeman, SR, Richard Irving, Simon K. Lloyd, Neil Donnelly, Shakeel R. Saeed, Taylor, RR, David Moffatt, Forge, A, Saeed, SR, Axon, P, Ruth R. Taylor, Monksfield, P, Simon R. Freeman, Chris Coulson, Tysome, J, Andrew Forge, Patrick Axon, James Tysome   +25 more
core   +1 more source

AAV-mediated rescue of Eps8 expression in vivo restores hair-cell function in a mouse model of recessive deafness

Molecular Therapy: Methods & Clinical Development, 2022
The transduction of acoustic information by hair cells depends upon mechanosensitive stereociliary bundles that project from their apical surface. Mutations or absence of the stereociliary protein EPS8 cause deafness in humans and mice, respectively ...
Jing-Yi Jeng, Adam J. Carlton, Richard J. Goodyear, Colbie Chinowsky, Federico Ceriani, Stuart L. Johnson, Tsung-Chang Sung, Yelena Dayn, Guy P. Richardson, Michael R. Bowl, Steve D.M. Brown, Uri Manor, Walter Marcotti   +12 more
doaj   +1 more source

Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice

eLife, 2017
Vestibular hair cells in the inner ear encode head movements and mediate the sense of balance. These cells undergo cell death and replacement (turnover) throughout life in non-mammalian vertebrates.
Stephanie A Bucks, Brandon C Cox, Brittany A Vlosich, James P Manning, Tot B Nguyen, Jennifer S Stone   +5 more
doaj   +1 more source

Hair follicle associated pluripotent (HAP) stem cells jump from transplanted whiskers to pelage follicles and stimulate hair growth

Scientific Reports, 2022
Stimulation of hair growth in hair loss has been a difficult goal to achieve. Hair follicle-associated pluripotent (HAP) stem cells express nestin and have been shown to differentiate to multiple cell types including keratinocytes, neurons, beating ...
Koya Obara, Jose Reynoso, Yuko Hamada, Yusuke Aoki, Yutaro Kubota, Noriyuki Masaki, Yasuyuki Amoh, Robert M. Hoffman   +7 more
doaj   +1 more source