Results 11 to 20 of about 463,740 (300)

Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals

open access: yeseLife, 2022
Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1 has been proposed as a potential therapeutic strategy for hearing loss.
Amrita A Iyer   +15 more
doaj   +1 more source

Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea [PDF]

open access: yes, 2020
Sound amplification within the mammalian cochlea depends upon specialized hair cells, the outer hair cells (OHCs), which possess both sensory and motile capabilities.
Ceriani, Federico   +7 more
core   +2 more sources

Hair Cell Generator Potentials [PDF]

open access: yesThe Journal of General Physiology, 1973
A technique is introduced using a piezoelectric device to stimulate hair cells of a molluscan statocyst while recording their responses intracellularly. Statocyst displacements produced with the technique are calibrated with stroboscopic photography. Properties of the hair cells' response to currents and mechanical stimulation are studied.
D L, Alkon, A, Bak
openaire   +2 more sources

Stepwise fate conversion of supporting cells to sensory hair cells in the chick auditory epithelium

open access: yesiScience, 2023
Summary: In contrast to mammals, the avian cochlea, specifically the basilar papilla, can regenerate sensory hair cells, which involves fate conversion of supporting cells to hair cells. To determine the mechanisms for converting supporting cells to hair
Mami Matsunaga   +7 more
doaj   +1 more source

Hair cell ribbon synapses [PDF]

open access: yesCell and Tissue Research, 2006
Hearing and balance rely on the faithful synaptic coding of mechanical input by the auditory and vestibular hair cells of the inner ear. Mechanical deflection of their stereocilia causes the opening of mechanosensitive channels, resulting in hair cell depolarization, which controls the release of glutamate at ribbon-type synapses.
Tobias, Moser   +2 more
openaire   +2 more sources

Hair Follicle Stem Cells [PDF]

open access: yesJournal of Investigative Dermatology Symposium Proceedings, 2003
The workshop on Hair Follicle Stem Cells brought together investigators who have used a variety of approaches to try to understand the biology of follicular epithelial stem cells, and the role that these cells play in regulating the hair cycle.
Lavker, Robert M   +11 more
openaire   +3 more sources

Hair cell afferent synapses [PDF]

open access: yesCurrent Opinion in Neurobiology, 2008
This review will cover advances in the study of hair cell afferent synaptic function occurring between 2005 and 2008. During this time, capacitance measurements of vesicular fusion have continued to be refined, optical methods have added insights regarding vesicle trafficking, and paired intracellular recordings have established the transfer function ...
Elisabeth, Glowatzki   +2 more
openaire   +2 more sources

Pattern formation in the basilar papilla: evidence for cell rearrangement. [PDF]

open access: yes, 1997
The avian basilar papilla is composed of hair and supporting cells arranged in a regular pattern in which the hair cells are surrounded and isolated from each other by supporting cell processes.
Goodyear, Richard, Richardson, Guy
core   +2 more sources

Mutations in ap1b1 Cause Mistargeting of the Na(+)/K(+)-ATPase Pump in Sensory Hair Cells. [PDF]

open access: yes, 2013
The hair cells of the inner ear are polarized epithelial cells with a specialized structure at the apical surface, the mechanosensitive hair bundle.
Clemens Grisham, Rachel   +4 more
core   +2 more sources

Beyond generalized hair cells: Molecular cues for hair cell types [PDF]

open access: yesHearing Research, 2013
Basic helix-loop-helix (bHLH) transcription factors (TFs) are crucial for inner ear neurosensory development. The proneural TF Atoh1 regulates the differentiation of hair cells (HCs) whereas Neurog1 and Neurod1 regulate specification and differentiation of neurons, respectively, but also affect HC development.
Israt, Jahan   +3 more
openaire   +2 more sources

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