Results 41 to 50 of about 10,895,649 (358)

Mechanosensory hair cells express two molecularly distinct mechanotransduction channels

Nature Neuroscience, 2016
Auditory hair cells contain mechanotransduction channels that rapidly open in response to sound-induced vibrations. We report here that auditory hair cells contain two molecularly distinct mechanotransduction channels.
Zizhen Wu, N. Grillet, Bo Zhao, Christopher L Cunningham, Sarah R. Harkins-Perry, B. Coste, Sanjeev S. Ranade, Navid Zebarjadi, M. Beurg, R. Fettiplace, A. Patapoutian, U. Mueller   +11 more
semanticscholar   +1 more source

Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells

Nature Communications, 2016
Inner ear sensory epithelia contain mechanosensitive hair cells that transmit information to the brain through innervation with bipolar neurons. Mammalian hair cells do not regenerate and are limited in number.
Xiao-ping Liu, Karl R. Koehler, A. Mikosz, E. Hashino, J. R. Holt   +4 more
semanticscholar   +1 more source

Gene Expression by Mouse Inner Ear Hair Cells during Development

Journal of Neuroscience, 2015
Hair cells of the inner ear are essential for hearing and balance. As a consequence, pathogenic variants in genes specifically expressed in hair cells often cause hereditary deafness. Hair cells are few in number and not easily isolated from the adjacent
D. Scheffer, Jun Shen, D. Corey, Zheng-Yi Chen   +3 more
semanticscholar   +1 more source

Hair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance

Scientific Reports, 2017
The mammalian sense of hearing relies on two types of sensory cells: inner hair cells transmit the auditory stimulus to the brain, while outer hair cells mechanically modulate the stimulus through active feedback.
Nikola Ciganović, Amanuel Wolde-Kidan, Tobias Reichenbach   +2 more
doaj   +1 more source

Characterization of the Transcriptome of Nascent Hair Cells and Identification of Direct Targets of the Atoh1 Transcription Factor

Journal of Neuroscience, 2015
Hair cells are sensory receptors for the auditory and vestibular system in vertebrates. The transcription factor Atoh1 is both necessary and sufficient for the differentiation of hair cells, and is strongly upregulated during hair-cell regeneration in ...
Tiantian Cai, Hsin-I Jen, Hyojin Kang, Tiemo J. Klisch, H. Zoghbi, A. Groves   +5 more
semanticscholar   +1 more source

Hair Follicle Generation by Injections of Adult Human Follicular Epithelial and Dermal Papilla Cells into Nude Mice

Cell Journal, 2017
Objective Dermal papilla and hair epithelial stem cells regulate hair formation and the growth cycle. Damage to or loss of these cells can cause hair loss.
Mohammadali Nilforoushzadeh, Elham Rahimi Jameh, Fariba Jaffary, Ehsan Abolhasani, Gelavizh Keshtmand, Hajar Zarkob, , Parvaneh Mohammadi, Nasser Aghdami   +7 more
doaj   +1 more source

Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells. [PDF]

PLoS ONE, 2014
To determine whether activated Notch can promote a supporting cell fate during sensory cell differentiation in the inner ear.An activated form of the Notch1 receptor (NICD) was expressed in early differentiating hair cells using a Gfi1-Cre mouse allele ...
Grace Savoy-Burke, Felicia A Gilels, Wei Pan, Diana Pratt, Jianwen Que, Lin Gan, Patricia M White, Amy E Kiernan   +7 more
doaj   +1 more source

The role of epigenetic modifications in sensory hair cell development, survival, and regulation

Frontiers in Cellular Neuroscience, 2023
The cochlea is the sensory organ in the periphery, and hair cells are its main sensory cells. The development and survival of hair cells are highly controlled processes.
Ying Xiao, Dan Li
doaj   +1 more source

Unlocking the vital role of host cells in hair follicle reconstruction by semi-permeable capsules. [PDF]

PLoS ONE, 2017
Organ regeneration is becoming a promising choice for many patients; however, many details about the mechanisms underlying organ regeneration remain unknown.
Zhexiang Fan, Yong Miao, Qian Qu, Shune Xiao, Jin Wang, Lijuan Du, Bingcheng Liu, Zhiqi Hu   +7 more
doaj   +1 more source

Hair-bearing human skin generated entirely from pluripotent stem cells

bioRxiv, 2019
The skin is a multilayered organ, equipped with appendages (that is, follicles and glands), that is critical for regulating body temperature and the retention of bodily fluids, guarding against external stresses and mediating the sensation of touch and ...
Jiyoon Lee, Cyrus C. Rabbani, Hongyu Gao, Matthew R. Steinhart, Benjamin M. Woodruff, Zachary E. Pflum, Alexander B. Kim, S. Heller, Yunlong Liu, Taha Z. Shipchandler, Karl R. Koehler   +10 more
semanticscholar   +1 more source