Results 81 to 90 of about 475,797 (351)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Integrity and regeneration of mechanotransduction machinery regulate aminoglycoside entry and sensory cell death. [PDF]

PLoS ONE, 2013
Sound perception requires functional hair cell mechanotransduction (MET) machinery, including the MET channels and tip-link proteins. Prior work showed that uptake of ototoxic aminoglycosides (AG) into hair cells requires functional MET channels. In this
Andrew A Vu, Garani S Nadaraja, Markus E Huth, Lauren Luk, John Kim, Renjie Chai, Anthony J Ricci, Alan G Cheng   +7 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells [PDF]

, 2018
In view of the prevalence of sensorineural hearing defects in an ageing population, the development of protocols to generate cochlear hair cells and their associated sensory neurons as tools to further our understanding of inner ear development are ...
A Chang, A Odawara, A Sans, AE Kiernan, BH Sokolowski, BM Ryals, CH Yoon, D Mukherjea, D Yang, DD Simmons, DJ Jagger, E Kim, E Longworth-Mills, EC Oesterle, EM Keithley, EM Keithley, H Qin, HL May-Simera, J Bok, JB Lee, JC Burns, JE Gale, K Nishimura, K Oshima, KR Koehler, KR Koehler, M Hanani, M Ronaghi, ME Warchol, MM Riccomagno, N Najafzadeh, NA Bermingham, P Chen, R Lim, RJ Helyer, S Chardin, T Cai, T Hayashi, T Liu, T Nakano, TJ Wright, V Matei, W Chen, W Marcotti, W Marcotti, XX Lou, Y Alvarez, Y Ouji, Y Ouji, YS Jang, YS Lee, Z Liu   +51 more
core   +3 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling

eLife, 2019
Loss of sensory hair cells leads to deafness and balance deficiencies. In contrast to mammalian hair cells, zebrafish ear and lateral line hair cells regenerate from poorly characterized support cells.
Mark E Lush, Daniel C Diaz, Nina Koenecke, Sungmin Baek, Helena Boldt, Madeleine K St Peter, Tatiana Gaitan-Escudero, Andres Romero-Carvajal, Elisabeth M Busch-Nentwich, Anoja G Perera, Kathryn E Hall, Allison Peak, Jeffrey S Haug, Tatjana Piotrowski   +13 more
doaj   +1 more source

Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity [PDF]

, 2017
Cisplatin-induced ototoxicity is one of the major factors limiting cisplatin chemotherapy. Ototoxicity results from damage to outer hair cells (OHCs) and other regions of the cochlea.
Bhatta, Puspanjali, Borse, Vikrant, Dhukhwa, Asmita, FH Al Aameri, Raheem, Ghosh, Sumana, Kaur, Tejbeer, Lowy, Michelle, Mukherjea, Debashree, Ramkumar, Vickram, Rybak, Leonard P, Sheehan, Kelly, Sheth, Sandeep, Tupal, Srinivasan   +12 more
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Approaches of auditory hair cells induction from stem cells

Otorhinolaryngology and Facial Plastic Surgery, 2017
Hair cells are the sensory epithelial cells of both the auditory and the vestibular systems in the inner ear of all vertebrates. Auditory hair cells are located in the organ of corti on a thin layer of basement membrane in the cochlea of the inner ear ...
Shahrokh Khoshsirat, Navid Ahmady Roozbahany, Somayeh Niknazar   +2 more
doaj   +1 more source

A simple method for purification of vestibular hair cells and non-sensory cells, and application for proteomic analysis. [PDF]

PLoS ONE, 2013
Mechanosensitive hair cells and supporting cells comprise the sensory epithelia of the inner ear. The paucity of both cell types has hampered molecular and cell biological studies, which often require large quantities of purified cells. Here, we report a
Meike Herget, Mirko Scheibinger, Zhaohua Guo, Taha A Jan, Christopher M Adams, Alan G Cheng, Stefan Heller   +6 more
doaj   +1 more source