Results 161 to 170 of about 8,406 (222)

All-at-once RNA folding with 3D motif prediction framed by evolutionary information. [PDF]

Nat Methods
Karan A, Rivas E.
europepmc   +1 more source

Autocatalytic assembly of a chimeric aminoacyl-RNA synthetase ribozyme. [PDF]

Sci Adv
Radakovic A, Todisco M, Mishra A, Szostak JW.   +3 more
europepmc   +1 more source

Selective Nonenzymatic Formation of Biologically Common RNA Hairpins. [PDF]

Angew Chem Int Ed Engl
Wu LF, Zhang J, Cornwell-Arquitt R, Hendrix DA, Radakovic A, Szostak JW.   +5 more
europepmc   +1 more source

An engineered U7 small nuclear RNA scaffold greatly increases ADAR-mediated programmable RNA base editing. [PDF]

Nat Commun
Byrne SM, Burleigh SM, Fragoza R, Jiang Y, Savva Y, Pabon R, Kania E, Rainaldi J, Portell A, Mali P, Briggs AW.   +10 more
europepmc   +1 more source

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The Hairpin Ribozyme

Methods, 1993
Abstract The hairpin ribozyme is a catalytic RNA capable of specifically cleaving a variety of substrate RNA sequences in either a cis or a trans reaction. The trans reaction has favorable catalytic and physical properties that make this ribozyme a potentially powerful in vivo regulator of gene expression.
Arnold Hampel, Steven Nesbitt, Richard Tritz, Mitchell Altschuler   +3 more
openaire   +1 more source

Hairpin ribozyme mediated RNA recombination

Chemical Communications, 2016
An engineered hairpin ribozyme supports the recombination of two non-functional substrates into a functional hammerhead ribozyme.
Robert, Hieronymus, Simon Peter, Godehard, Darko, Balke, Sabine, Müller   +3 more
openaire   +2 more sources

Ribozymes: the hairpin and Varkud ribozymes are related.

Rivista di biologia, 2004
The hairpin ribozyme of plant virusoids and the Varkud ribozyme from a retroplasmid of fungal mitochondria show notable similarities in sequence and secondary structure. Some more distant inter-relationships appear to exist between this pair, the viroid/virusoid hammerhead and the hepatitis delta ribozyme.
Elder, David, Harris, Ray J.
openaire   +2 more sources

The hairpin ribozyme

Biopolymers, 2003
AbstractThe hairpin ribozyme is a naturally occurring RNA that catalyzes sequence‐specific cleavage and ligation of RNA. It has been the subject of extensive biochemical and structural studies, perhaps the most detailed for any catalytic RNA to date. Comparison of the structures of its constituent domains free and fully assembled demonstrates that the ...
openaire   +2 more sources

Functional Domain-Assembly in Hairpin Ribozymes

Journal of Biochemistry, 2000
Functional structures of hairpin ribozymes have been investigated by constructing various chemically modified molecules. Domain-exchange and linker insertion experiments were performed to find active conformations of the RNA enzyme showing cleavage activity.
Y, Komatsu, I, Kanzaki, M, Shirai, I, Kumagai, S, Yamashita, E, Ohtsuka   +5 more
openaire   +2 more sources