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Rapid discovery of functional RNA domains. [PDF]
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Abstract The hairpin ribozyme is a catalytic RNA capable of specifically cleaving a variety of substrate RNA sequences in either a cis or a trans reaction. The trans reaction has favorable catalytic and physical properties that make this ribozyme a potentially powerful in vivo regulator of gene expression.
Steven Nesbitt+3 more
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The hairpin ribozyme: structure, assembly and catalysis [PDF]
Recent studies of the hairpin ribozyme have revealed a distinct catalytic mechanism for this small RNA motif. Inner-sphere coordinated metal ions are not required, as the inert metal ion complex cobalt hexammine promotes catalysis. Detailed kinetic analyses have defined rates of individual steps in the catalytic cycle.
Nils G. Walter, John M. Burke
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Ribozymes: the hairpin and Varkud ribozymes are related.
Rivista di biologia, 2003The hairpin ribozyme of plant virusoids and the Varkud ribozyme from a retroplasmid of fungal mitochondria show notable similarities in sequence and secondary structure. Some more distant inter-relationships appear to exist between this pair, the viroid/virusoid hammerhead and the hepatitis delta ribozyme.
David Elder, Ray J. Harris
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