Results 1 to 10 of about 1,585,431 (199)

Seasonal Stability of SARS-CoV-2 in Biological Fluids

open access: yesPathogens, 2021
The transmission of SARS-CoV-2 occurs by close contact with infected persons through droplets, the inhalation of infectious aerosols, and the exposure to contaminated surfaces.
Taeyong Kwon   +2 more
doaj   +1 more source

DEVELOPMENT OF DELIVERY SYSTEM FOR TRANSFERRIN USING CHEMICAL MODIFICATION APPROACH [PDF]

open access: yesBasrah Journal of Veterinary Research, 2012
Proteins are very important molecules as therapeutics. They have several advantages over small molecule drugs but their use is limited by their circulation short half life, immunogenicity and physicochemical instability.
Athmar D. Habeeb
doaj   +1 more source

Orally Administered, Biodegradable and Biocompatible Hydroxypropyl–β–Cyclodextrin Grafted Poly(methacrylic acid) Hydrogel for pH Sensitive Sustained Anticancer Drug Delivery

open access: yesGels, 2022
In the current study, a pH sensitive intelligent hydroxypropyl–β–cyclodextrin-based polymeric network (HP-β-CD-g-MAA) was developed through a solution polymerization technique for site specific delivery of cytarabine in the colonic region.
Nighat Batool   +7 more
doaj   +1 more source

Characterization of pre-existing anti-PEG and anti-AGAL antibodies towards PRX-102 in patients with Fabry disease

open access: yesFrontiers in Immunology, 2023
Polyethylene glycol (PEG)ylated drugs are used for medical treatment, since PEGylation either decreases drug clearance or/and shields the protein from undesirable immunogenicity.
Malte Lenders   +3 more
doaj   +1 more source

Understanding the Opportunities to Mitigate Carryover of Imidazolinone Herbicides in Lowland Rice

open access: yesAgriculture, 2021
(1) Background: The Clearfield™ system (CL) is currently the primary tool for selective weedy-rice management in irrigated rice. However, herbicide persistence in the soil may cause damage to successive crops.
Vinicios Rafael Gehrke   +3 more
doaj   +1 more source

The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

open access: yeseLife, 2020
Osteocalcin (OCN) is an osteoblast-derived hormone with pleiotropic physiological functions. Like many peptide hormones, OCN is subjected to post-translational modifications (PTMs) which control its activity.
Omar Al Rifai   +7 more
doaj   +1 more source

Dynamics of Hepatitis B Virus Covalently Closed Circular DNA: A Mini-Review

open access: yesMicroorganisms, 2023
Eradication of cccDNA is an ideal goal of chronic hepatitis B (CHB) therapy. Understanding the changes in the cccDNA pool during therapy provides a basis for developing CHB treatment strategies.
Jie-Li Hu, Ai-Long Huang
doaj   +1 more source

Determining the Time of Booster Dose Based on the Half-Life and Neutralization Titers against SARS-CoV-2 Variants of Concern in Fully Vaccinated Individuals

open access: yesMicrobiology Spectrum, 2023
Although mRNA-based COVID-19 vaccines reduce the risk of severe disease, hospitalization and death, vaccine effectiveness (VE) against infection and disease from variants of concern (VOC) wanes over time.
Yu-Ching Dai   +8 more
doaj   +1 more source

Porcine Epidemic Diarrhea Virus, Surrogate for Coronavirus Decay Measurement in French Coastal Waters and Contribution to Coronavirus Risk Evaluation

open access: yesMicrobiology Spectrum, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in infected patients mainly displays pulmonary and oronasal tropism; however, the presence of the virus has also been demonstrated in the stools of patients and consequently in wastewater ...
Maud Contrant   +6 more
doaj   +1 more source

Research on the Application of Half-life Indexes in Periodical Evaluation

open access: yesZhishi guanli luntan, 2018
[Purpose/significance] Based on the review of half-life indexes in periodical evaluation at home and abroad, this paper finds that half-life indexes are mixed and misused in the process of being used. so, we analyze and explore these problems.
Zhao Nan
doaj   +1 more source

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