Results 71 to 80 of about 8,886,396 (384)

Fc Sialylation Prolongs Serum Half-Life of Therapeutic Antibodies

Journal of Immunology, 2019
The long serum t1/2 of IgGs is ensured by their interaction with the neonatal Fc receptor (FcRn), which salvages IgG from intracellular degradation. Fc glycosylation is thought not to influence FcRn binding and IgG longevity in vivo.
M. Bas, Aurélie Terrier, E. Jacque, Aurélie Dehenne, Virginie Pochet-Béghin, Cécile Beghin, A. Dezetter, G. Dupont, Anaïs Engrand, B. Beaufils, P. Mondon, N. Fournier, C. de Romeuf, S. Jorieux, A. Fontayne, L. Mars, C. Monnet   +16 more
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Study into impacts of formation sands on foam performance during drainage gas production—Take Qinghai Oilfield’s Sebei Gasfield for example

Frontiers in Earth Science, 2023
Foam drainage gas production is a gas production technology for low-pressure gas well in domestic and abroad industries. In Qinghai Oilfield’s Sebei Gasfield, sand existence often occurs during drainage production.
Nan Li, Weidong Jiang, Yixin Jiang, Jinmin Yang, Guangqiang Cao, Rui Zheng, Daqiang Feng, Haoyu Wang, Zhiyu Xu, Bin Peng, Furong Li, Ruixin Kang, Qiubo Wu   +12 more
doaj   +1 more source

Strategy for Extending Half-life in Drug Design and Its Significance.

ACS Medicinal Chemistry Letters, 2018
Preclinical optimization of compounds toward viable drug candidates requires an integrated understanding of properties that impact predictions of the clinically efficacious dose.
H. Gunaydin, Michael D. Altman, J. Michael Ellis, P. Fuller, Scott A. Johnson, B. Lahue, Blair T. Lapointe   +6 more
semanticscholar   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Utility of Feathers for Avian Influenza Virus Detection in Commercial Poultry

Pathogens, 2023
The present study evaluated the potential utility of feather samples for the convenient and accurate detection of avian influenza virus (AIV) in commercial poultry. Feather samples were obtained from AIV-negative commercial layer facilities in Iowa, USA.
Shahan Azeem, Baoqing Guo, Yuko Sato, Phillip C. Gauger, Anna Wolc, Kyoung-Jin Yoon   +5 more
doaj   +1 more source

The impact of extended half-life versus conventional factor product on hemophilia caregiver burden

Quality of Life Research, 2018
IntroductionExtended half-life factor products have reduced annualized bleeding rates in hemophilia patients. The impact of extended half-life versus conventional factor products on hemophilia caregiver burden has not been investigated.
C. Schwartz, Victoria E. Powell, Jun Su, Jie Zhang, A. Eldar-Lissai   +4 more
semanticscholar   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

High-precision measurement of the half-life of $^{62}$Ga

, 2003
The beta-decay half-life of 62Ga has been studied with high precision using on-line mass separated samples. The decay of 62Ga which is dominated by a 0+ to 0+ transition to the ground state of 62Zn yields a half-life of T_{1/2} = 116.19(4) ms.
Blank, B., Blazhev, A., Canchel, G., Chartier, M., Doring, J., Henderson, D., Janas, Z., Kirchner, R., Mukha, I., Roeckl, E., Savard, G., Schmidt, K., Zylicz, J.   +12 more
core   +2 more sources