Results 81 to 90 of about 8,775,047 (381)
The impact of extended half-life versus conventional factor product on hemophilia caregiver burden
Quality of Life Research, 2018 IntroductionExtended half-life factor products have reduced annualized bleeding rates in hemophilia patients. The impact of extended half-life versus conventional factor products on hemophilia caregiver burden has not been investigated.
C. Schwartz +4 more
semanticscholar +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Measuring the Pharmacokinetic Properties of Drugs with a Novel Surgical Rat Model
Journal of Investigative Surgery, 2017 Purpose/aim of the study: The pharmacokinetic (PK) parameters in animal models can help optimize novel candidate drugs prior to human trials. However, due to the complexity of pharmacokinetic experiments, their use is limited in academia.
Ioannis Christakis +6 more
doaj +1 more source
Forming cytoophidia prolongs the half-life of CTP synthase
Cell Discovery, 2019 Dear Editor, Intracellular compartmentation of biological processes is fundamental for a cell to function. One method is to form membrane-bound organelles, such as the mitochondria, endoplasmic reticulum (ER), and lysosomes, which have been extensively ...
Zhe Sun, Ji-Long Liu
semanticscholar +1 more source
FEBS Letters, EarlyView.The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet +4 more
wiley +1 more source
Understanding the Opportunities to Mitigate Carryover of Imidazolinone Herbicides in Lowland Rice
Agriculture, 2021 (1) Background: The Clearfield™ system (CL) is currently the primary tool for selective weedy-rice management in irrigated rice. However, herbicide persistence in the soil may cause damage to successive crops.
Vinicios Rafael Gehrke +3 more
doaj +1 more source
Half Life of the Doubly-magic r-Process Nucleus 78Ni
, 2005 Nuclei with magic numbers serve as important benchmarks in nuclear theory. In addition, neutron-rich nuclei play an important role in the astrophysical rapid neutron-capture process (r-process).
A. Aprahamian +26 more
core +1 more source
The lifetime of excess atmospheric carbon dioxide [PDF]
, 1994 We explore the effects of a changing terrestrial biosphere on the atmospheric residence time of CO2 using three simple ocean carbon cycle models and a model of global terrestrial carbon cycling.
Braswell, Rob, Moore, B
core +2 more sources
FEBS Letters, EarlyView.α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley +1 more source
Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis
Aging and Cancer, Volume 3, Issue 3-4, Page 133-146, September-December 2022., 2022 One‐third of DLBCL arises from extranodal organs and is challenging to manage. Molecular features are critical to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and ...
Si‐Yuan Chen +3 more
wiley +1 more source