Results 101 to 110 of about 313 (213)
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
The Astrophysical Journal LettersUsing numerical simulations of a barred disk galaxy embedded in nonspinning and spinning dark matter (DM) halos, we present a novel mechanism of “cooling” the vertical oscillations of DM particles, which acquire disk kinematics.
Xingchen Li +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
On the Use of Field RR Lyrae as Galactic Probes. VIII. Early Formation of the Galactic Spheroid
The Astrophysical JournalWe introduce a new photometric catalog of RR Lyrae (RRL) variables (∼300,000) mainly based on data available in public datasets. We also present the largest and most homogeneous spectroscopic dataset of RRLs and blue horizontal branch (BHB) stars ever ...
G. Bono +56 more
doaj +1 more source
Bifurcation Mechanism of Quasi-Halo Orbit from Lissajous Orbit
Journal of Guidance, Control, and DynamicsThis paper presents a general analytical method to describe the center manifolds of collinear libration points in the restricted three-body problem (RTBP). It is well known that these center manifolds include Lissajous orbits, halo orbits, and quasi-halo orbits.
Mingpei Lin, Hayato Chiba
openaire +2 more sources
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection
FEBS Open Bio, EarlyView.Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow +12 more
wiley +1 more source
The Astrophysical JournalGalaxy merger timescales are crucial for understanding and modeling galaxy formation in our hierarchically structured Universe. However, previous studies have reported widely varying dependencies of merger timescales on initial orbital parameters and ...
Kun Xu, Y. P. Jing
doaj +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source