Results 41 to 50 of about 25,792 (269)

Natural and Synthetic Halogenated Amino Acids—Structural and Bioactive Features in Antimicrobial Peptides and Peptidomimetics

Molecules, 2021
The 3D structure and surface characteristics of proteins and peptides are crucial for interactions with receptors or ligands and can be modified to some extent to modulate their biological roles and pharmacological activities. The introduction of halogen
Mario Mardirossian, Marina Rubini, Mauro F. A. Adamo, Marco Scocchi, Michele Saviano, Alessandro Tossi, Renato Gennaro, Andrea Caporale   +7 more
doaj   +1 more source

Recent advances in Flavin-dependent halogenase biocatalysis : sourcing, engineering, and application [PDF]

, 2019
The introduction of a halogen atom into a small molecule can effectively modulate its properties, yielding bioactive substances of agrochemical and pharmaceutical interest.
Buller, Rebecca, Büchler, Johannes, Papadopoulou, Athena   +2 more
core   +1 more source

Further Characterization of Fungal Halogenase RadH and Its Homologs

Biomolecules, 2023
RadH is one of the flavin-dependent halogenases that has previously exhibited promising catalytic activity towards hydroxycoumarin, hydroxyisoquinoline, and phenolic derivatives.
GuangRong Peh, Gregory A. Gunawan, Terence Tay, Elaine Tiong, Lee Ling Tan, Shimin Jiang, Yi Ling Goh, Suming Ye, Joel Wong, Christopher J. Brown, Huimin Zhao, Ee Lui Ang, Fong Tian Wong, Yee Hwee Lim   +13 more
doaj   +1 more source

Linking forest cover, soil erosion and mire hydrology to late-Holocene human activity and climate in NW Spain [PDF]

, 2014
This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further ...
Aira Rodríguez MJ, Benito E, Carrión Y, Cheburkin AK, Clymo RS, Costa Casais M, FAO, Fægri K, García Salinas F, Goeury C, Grimm EC, Grimm EC, Innes JB, Martínez Cortizas A, Rochette Cordeiro AM, Siiriäinen A, Smith AG, Starkel L, Taboada Castro MT, Taboada Castro MT, Van Andel TH, Van Geel B, Van Geel B, Vánky K   +23 more
core   +1 more source

Stable BF2 Boracycles as Versatile Reagents for Selective Ortho C–H Functionalization

Angewandte Chemie, EarlyView.
We report a robust, metal‐free and scalable synthesis of stable BF2 boracycles via directed ortho CH borylation, delivering isolable, shelf‐stable reagents without chromatographic purification. These BF2 boracycles exhibit unique and tunable reactivity, enabling highly selective ipso‐functionalization across a broad range of transformations.
Ganesh H. Shinde, Jonatan Babiker, Michelle Mebrahtu, Anaïs Prigent, Gauthier Foucras, Yogesh N. Aher, Francoise M. Amombo Noa, Magnus J. Johansson, Janez Košmrlj, Ross D. Jansen‐van Vuuren, Thomas Cailly, Henrik Sundén   +11 more
wiley   +2 more sources

In Silico and Experimental Investigation of the Biological Potential of Some Recently Developed Carprofen Derivatives

Molecules, 2022
The efficient regioselective bromination and iodination of the nonsteroidal anti-inflammatory drug (NSAID) carprofen were achieved by using bromine and iodine monochloride in glacial acetic acid.
Florea Dumitrascu, Ana-Maria Udrea, Mino R. Caira, Diana Camelia Nuta, Carmen Limban, Mariana Carmen Chifiriuc, Marcela Popa, Coralia Bleotu, Anamaria Hanganu, Denisa Dumitrescu, Speranta Avram   +10 more
doaj   +1 more source

Unnatural Amino Acid and Emerging Chemistry Approaches to Map RNA–Protein Interactions

Angewandte Chemie, EarlyView.
This review highlights emerging chemistries for mapping RNA–protein interactions, including genetically encoded unnatural amino acids, novel photocrosslinkers, and non‐photoactivatable crosslinking systems. We compare their mechanisms, reactivity and applications, outlining how these next‐generation tools enable higher‐resolution, site‐specific ...
Eryn Lundrigan, Parrish Evers, Elexa Scott, John Paul Pezacki   +3 more
wiley   +2 more sources

Mechanism and application of halogenation–dehalogenation in the development of pitch-based carbon fiber: A review

Journal of Engineered Fibers and Fabrics, 2023
Pitch-based carbon fiber, as one of the important engineering materials, has been widely used in aerospace, defense, sports, and other fields. In the long production process of pitch-based carbon fiber, the property of pitch precursor is significant for ...
Jinchang Liu, Qin Liu, Xiaoya An, Tong Wang, Dingcheng Liang, Qiang Xie   +5 more
doaj   +1 more source

Biotransformation of halogenated compounds by lyophilized cells of Rhodococcus erythropolis in a continuous solid-gas biofilter [PDF]

, 2004
The irreversible hydrolysis of 1-chlorobutane to 1-butanol and HCl by lyophilized cells of Rhodococcus erythropolis NCIMB 13064, using a solid–gas biofilter, is described as a model reaction.
Erable, Benjamin, Goubet, Isabelle, Lamare, Sylvain, Legoy, Marie Dominique, Maugard, Thierry   +4 more
core   +4 more sources

Halide Bond Assisted Double Desymmetrization of Meso‐Dicarboxylic Acids with Symmetrical Olefins via Asymmetric Halogenation

Angewandte Chemie, EarlyView.
This work demonstrates a double desymmetrization of meso‐dicarboxylic acids with symmetrical olefins, constructing complex chiral lactones with six stereocenters in one step. Unexpectedly, the halide bond was found to be crucial in achieving high stereoselectivity.
Qingyu Zhang, Haihui Wang, Ying‐Lung Steve Tse, Ying‐Yeung Yeung   +3 more
wiley   +2 more sources