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Effects of Haloperidol on Cardiac Histamine H₂ Receptors and β-Adrenoceptors in Isolated Mouse and Human Atrial Preparations [PDF]

NeuroSci
The antipsychotic drug haloperidol is found on the WHO list of essential drugs. In vitro, haloperidol demonstrates binding affinity for various receptors, including histamine H2 receptors (H2Rs).
Jonas M. A. Schlicht, Britt Hofmann, Uwe Kirchhefer, Joachim Neumann, Ulrich Gergs   +4 more
doaj   +2 more sources

Rapid tranquilization for agitated patients in emergency psychiatric rooms: a randomized trial of olanzapine, ziprasidone, haloperidol plus promethazine, haloperidol plus midazolam and haloperidol alone Tranquilização rápida para pacientes agitados nos serviços de emergência psiquiátrica: um ensaio clínico randomisado de olanzapina, ziprasidona, haloperidol mais prometazina, haloperidol mais midazolam e haloperidol em monoterapia [PDF]

Brazilian Journal of Psychiatry, 2011
OBJECTIVE: To compare the effectiveness of intramuscular olanzapine, ziprasidone, haloperidol plus promethazine, haloperidol plus midazolam and haloperidol alone as the first medication(s) used to treat patients with agitation and aggressive behavior ...
Leonardo Baldaçara, Marsal Sanches, Daniel Cruz Cordeiro, Andrea Parolin Jackowski   +3 more
doaj   +5 more sources

The Developmental Toxicity of Haloperidol on Zebrafish (Danio rerio) Embryos [PDF]

Biomedicines
Background/Objectives: Haloperidol is a typical antipsychotic drug widely used for acute confusional state, psychotic disorders, agitation, delirium, and aggressive behavior.
Maximos Leonardos, Charis Georgalis, Georgia Sergiou, Dimitrios Leonardos, Lampros Lakkas, George A. Alexiou   +5 more
doaj   +2 more sources

Incidence of Orthostatic Hypotension in Schizophrenic Patients Using Antipsychotics at Sambang Lihum Mental Health Hospital, South Kalimantan

Borneo Journal of Pharmacy, 2021
Schizophrenia is a psychiatric disorder that requires antipsychotics therapy. Antipsychotics cause many side effects, including orthostatic hypotension.
Noor Cahaya, Sandra Putri Wijaya, Khoerul Anwar   +2 more
doaj   +1 more source

Differential changes in QTc duration during in-hospital haloperidol use. [PDF]

PLoS ONE, 2011
AIMS: To evaluate changes in QT duration during low-dose haloperidol use, and determine associations between clinical variables and potentially dangerous QT prolongation. METHODS: In a retrospective cohort study in a tertiary university teaching hospital
Marieke T Blom, Abdennasser Bardai, Barbara C van Munster, Mei-Ing Nieuwland, Hendrik de Jong, Daniel A van Hoeijen, Anne M Spanjaart, Anthonius de Boer, Sophia E de Rooij, Hanno L Tan   +9 more
doaj   +1 more source

Effects of cannabidiol on weight and fasting blood sugar with chronic and subchronic haloperidol administration

Discover Mental Health, 2022
Objectives The duration of administration (e.g., subchronic or chronic) of haloperidol may influence its adverse effects. We studied the effects of duration of administration of haloperidol on body weight and fasting blood sugar (FBS).
Jaiyeola Abiola Kajero, Soraya Seedat, Jude U. Ohaeri, Abidemi Akindele, Oluwagbemiga Aina   +4 more
doaj   +1 more source

Acute Extrapyramidal Side Effects from Smoked Haloperidol

Case Reports in Psychiatry, 2021
Introduction. Haloperidol is a dopamine receptor antagonist used to treat patients with psychotic disorders. Especially at high doses, haloperidol carries a higher risk of extrapyramidal symptoms (EPS) compared to second-generation antipsychotics.
Angeline Pham, Joo-Young Lee, Christopher W. T. Miller   +2 more
doaj   +1 more source

Assessment of Protective Effects of Carvacrol on Haloperidol-Induced Oxidative Stress and Genotoxicity in Human Peripheral Blood Lymphocytes

Journal of Toxicology, 2022
Haloperidol is a first-generation antipsychotic drug that has several indications in a wide range of mental conditions. The extensive prescription of haloperidol is correlated with some less-known adverse effects such as genotoxicity.
Ehsan Zamani, Alireza Ahmadi Shad, Hediye Fatemi, Saba Mahboubi, Azadeh Motavallian, Mehdi Evazalipour   +5 more
doaj   +1 more source

Haloperidol aggravates transverse aortic constriction-induced heart failure via mitochondrial dysfunction

Journal of Pharmacological Sciences, 2016
Haloperidol is an antipsychotic drug that inhibits the dopamine D2 receptor among others. Haloperidol also binds the sigma-1 receptor (σ1R) and inhibits it irreversibly. A serious outcome of haloperidol treatment of schizophrenia patients is death due to
Yasuharu Shinoda, Hideaki Tagashira, Md. Shenuarin Bhuiyan, Hideyuki Hasegawa, Hiroshi Kanai, Kohji Fukunaga   +5 more
doaj   +1 more source

Effect of the antipsychotic drug haloperidol on arrhythmias during acute myocardial infarction in a porcine model

International Journal of Cardiology: Heart & Vasculature, 2020
Patients receiving psychiatric medication, like the antipsychotic drug haloperidol, are at an increased risk of sudden cardiac death (SCD). Haloperidol blocks the cardiac rapidly-activating delayed rectifier potassium current, thereby increasing ...
Stefan M. Sattler, Anniek F. Lubberding, Charlotte B. Kristensen, Rasmus Møgelvang, Paul Blanche, Anders Fink-Jensen, Thomas Engstrøm, Stefan Kääb, Thomas Jespersen, Jacob Tfelt-Hansen   +9 more
doaj   +1 more source