Results 41 to 50 of about 61,813 (248)

Preventing ICU Subsyndromal Delirium Conversion to Delirium With Low-Dose IV Haloperidol: A Double-Blind, Placebo-Controlled Pilot Study*

Critical Care Medicine, 2016
Objective:To compare the efficacy and safety of scheduled low-dose haloperidol versus placebo for the prevention of delirium (Intensive Care Delirium Screening Checklist ≥ 4) administered to critically ill adults with subsyndromal delirium (Intensive ...
Nada S. Al-Qadheeb, Y. Skrobik, Greg L. Schumaker, M. Pacheco, Russel J. Roberts, R. Ruthazer, J. Devlin   +6 more
semanticscholar   +1 more source

A descriptive analysis of pharmacological management of aggression and/or agitation in patients with traumatic brain injury in a Southwest Virginia inpatient population

Journal of Clinical Pharmacy and Therapeutics, Volume 47, Issue 12, Page 2083-2090, December 2022., 2022
Traumatic brain injury (TBI) is a major cause of disability, and it has been associated with agitation and aggression. In this study, we examined the psycho‐pharmacological agents that were administered to patients with agitation and/or aggression in the context of TBI in inpatient facilities of a private, non‐profit health care system in Southwest ...
Elham Rahmani, Tricia Lemelle, Hunter Sharp, Ehsan Smarbafzadeh, Anita Kablinger   +4 more
wiley   +1 more source

Haloperidol plus promethazine for psychosis-induced aggression.

Cochrane Database of Systematic Reviews, 2016
BACKGROUND Health services often manage agitated or violent people, and such behaviour is particularly prevalent in emergency psychiatric services (10%).
G. Huf, J. Alexander, Pinky Gandhi, M. Allen   +3 more
semanticscholar   +1 more source

Haloperidol Induced Cell Cycle Arrest and Apoptosis in Glioblastoma Cells

Biomedicines, 2020
Although several antipsychotic drugs have been shown to possess anticancer activities, haloperidol, a “first-generation” antipsychotic drug, has not been extensively evaluated for potential antineoplastic properties.
Fotios Papadopoulos, Rafaela Isihou, George A. Alexiou, Thomas Tsalios, Evrysthenis Vartholomatos, Georgios S. Markopoulos, Chrissa Sioka, Pericles Tsekeris, Athanasios P. Kyritsis, Vasiliki Galani   +9 more
doaj   +1 more source

Two Sudden and Unexpected Deaths of Patients with Schizophrenia Associated with Intramuscular Injections of Antipsychotics and Practice Guidelines to Limit the Use of High Doses of Intramuscular Antipsychotics

Case Reports in Psychiatry, 2016
Intravenous haloperidol has been associated with torsades de pointes (TdP). These two sudden deaths were probable adverse drug reactions (ADRs) following intramuscular (IM) antipsychotics.
Nasratullah Wahidi, Katie M. Johnson, Allen Brenzel, Jose de Leon   +3 more
doaj   +1 more source

Randomized Controlled Double‐blind Trial Comparing Haloperidol Combined With Conventional Therapy to Conventional Therapy Alone in Patients With Symptomatic Gastroparesis

Academic Emergency Medicine, 2017
OBJECTIVE Gastroparesis is a debilitating condition that causes nausea, vomiting, and abdominal pain. Management includes analgesics and antiemetics, but symptoms are often refractory.
C. Roldan, K. Chambers, L. Paniagua, Sonali Patel, M. Cárdenas-Turanzas, Y. Chathampally   +5 more
semanticscholar   +1 more source

The impact of ABCDE bundle implementation on patient outcomes: A nationwide cohort study

Nursing in Critical Care, Volume 27, Issue 6, Page 772-783, November 2022., 2022
Abstract Background The ABCDE bundle is a set of evidence‐based practices to systematically reduce the risks of sedation, delirium, and immobility in intensive care patients. Implementing the bundle improves clinical outcome. Aims and Objectives To investigate the association between patient outcomes and compliance with bundle components ABC ...
María Jesús Frade‐Mera, Susana Arias‐Rivera, Ignacio Zaragoza‐García, Joan Daniel Martí, Elisabet Gallart, Alicia San José‐Arribas, Tamara Raquel Velasco‐Sanz, Eva Blazquez‐Martínez, Marta Raurell‐Torredà   +8 more
wiley   +1 more source

Haloperidol Abrogates Matrix Metalloproteinase-9 Expression by Inhibition of NF-κB Activation in Stimulated Human Monocytic Cells

Mediators of Inflammation, 2018
Much evidence has indicated that matrix metalloproteinases (MMPs) participate in the progression of neuroinflammatory disorders. The present study was undertaken to investigate the inhibitory effect and mechanism of the antipsychotic haloperidol on MMP ...
Yueh-Lun Lee, Che-Jen Hsiao, Fan-Li Lin, Jing-Shiun Jan, Yung-Chen Chou, Yen-Yu Lin, Chih-Kuang Chen, Kwok-Keung Lam, George Hsiao   +8 more
doaj   +1 more source

Haloperidol Induced Sudden Cardiac Arrest—Report of a Very Rare Case and Review of Literature

Case Reports in Psychiatry, 2020
Haloperidol is a typical antipsychotic drug. This drug is still widely used in emergency medicine, psychiatry, and general medicine departments. It is mostly used for acute confusional state, psychotic disorders, agitation, delirium, and aggressive ...
Parvez Mohi-Ud-Din Dar, Supreet Kaur, Jogendra Boddeda, Sajid Mohammad Wani   +3 more
doaj   +1 more source

Brain Targeting of a Water Insoluble Antipsychotic Drug Haloperidol via the Intranasal Route Using PAMAM Dendrimer.

Molecular Pharmaceutics, 2015
Delivery of therapeutics to the brain is challenging because many organic molecules have inadequate aqueous solubility and limited bioavailability.
Y. Katare, R. Daya, Christal Sookram Gray, Roger E Luckham, J. Bhandari, A. Chauhan, Ram K. Mishra   +6 more
semanticscholar   +1 more source