Results 51 to 60 of about 37,713 (238)

Tics and Parkinson's Disease: Clinical and Pathophysiological Insights from a Rare Syndromic Association

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background The coexistence of tics with Parkinson's disease (PD) is rare, as they often emerge at different ages, follow different trajectories and involve contrasting pathophysiological mechanisms related to dopamine availability and function in the brain. Cases We present 10 individuals with primary tic disorders who later developed PD.
Tarig Abkur   +11 more
wiley   +1 more source

Unveiling the Therapeutic Potential of Atractylis aristata Batt. Aqueous Extract: Anti‐inflammatory, Antioxidant, Antibacterial, Sedative Activities & Phytochemical Profiling

open access: yesChemistryOpen, EarlyView.
This study evaluates the pharmacological properties of the aqueous extract of Atractylis aristata, focusing on its antioxidant, anti‐inflammatory, antibacterial, and sedative activities. Phytochemical analysis identifies bioactive compounds, while in vitro and in vivo tests demonstrate its therapeutic potential in addressing oxidative stress ...
Asma Abid   +14 more
wiley   +1 more source

Comparison of the incidence of recovery agitation with two different doses of ketamine in procedural sedation: A randomized clinical trial

open access: yesAcademic Emergency Medicine, EarlyView.
Abstract Objectives The objective was to compare the incidence of recovery agitation and efficacy of two different intravenous (IV) doses of ketamine (0.5 mg/kg vs. 1 mg/kg) in adult patients who presented to the emergency department (ED) requiring procedural sedation with ketamine.
Çağrı Türkücü   +4 more
wiley   +1 more source

Effects of haloperidol inhalation on MK-801- and memantine-induced locomotion in mice

open access: yesLibyan Journal of Medicine, 2020
The administration of therapeutic agents is difficult in many patients, such as patients with post-operative delirium or dementia or patients with schizophrenia, who are upset in an emergency room.
Hiroshi Ueno   +8 more
doaj   +1 more source

Managing Acute Behavioural Disturbance in Perinatal Women: A Systematic and State of the Art Review of Guidelines

open access: yesAustralian and New Zealand Journal of Obstetrics and Gynaecology, EarlyView.
ABSTRACT Background Guidelines for managing acute behavioural disturbance typically exclusively focus on care for adults in mental health and related settings, how this should be adapted to safely manage in pregnancy and the early postpartum including in settings such as maternity wards is less clear. Aims To undertake a systematic and state of the art
Megan Galbally   +6 more
wiley   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

open access: yesBritish Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander   +5 more
wiley   +1 more source

Blonanserin versus haloperidol in Japanese patients with schizophrenia: A phase 3, 8‐week, double‐blind, multicenter, randomized controlled study

open access: yesNeuropsychopharmacology Reports, 2019
Objective This Japanese, multicenter, randomized, double‐blind trial, evaluating the efficacy and safety of blonanserin compared with haloperidol in patients with schizophrenia, was previously published by Murasaki in the Japanese language.
Philip D. Harvey   +2 more
doaj   +1 more source

Critical insights into the potential risks of antipsychotic drugs to fish, including through effects on behaviour

open access: yesBiological Reviews, EarlyView.
ABSTRACT Antipsychotic drugs (APDs) are a diverse class of neuroactive pharmaceuticals increasingly detected in surface and ground waters globally. Some APDs are classified as posing a high environmental risk, due, in part, to their tendency to bioaccumulate in wildlife, including fish.
Gabrielle Wasser‐Bennett   +4 more
wiley   +1 more source

The Impact of Metformin on Plasma Prolactin Levels in Antipsychotics‐Treated Men With Hyperprolactinemia and Early‐Onset Androgenic Alopecia

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Objective Metformin decreases elevated levels of pituitary hormones. Little is known about the association between the reproductive axis and hormonal effects of this drug. The purpose of our study was to investigate whether activity of the hypothalamic‐pituitary‐gonadal axis determines metformin action on prolactin levels in men with prolactin
Robert Krysiak   +4 more
wiley   +1 more source

Effects of Tandospirone, a 5-HT1A Agonistic Anxiolytic Agent, on Haloperidol-Induced Catalepsy and Forebrain Fos Expression in Mice

open access: yesJournal of Pharmacological Sciences, 2009
We studied the effects of tandospirone, a 5-HT1A agonistic anxiolytic agent, on haloperidol-induced catalepsy and forebrain Fos expression in mice. Haloperidol (0.5 mg/kg, i.p.) markedly increased the catalepsy time and enhanced Fos expression in the ...
Yukihiro Ohno, Saki Shimizu, Junta Imaki
doaj  

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