Results 41 to 50 of about 52,692 (254)

Enantioconvergent Cobalt‐Catalyzed Hydroalkylation for the Construction of Fluoro, Chloro, and Trifluoromethyl Stereogenic Centers

open access: yesAngewandte Chemie, Volume 137, Issue 32, August 4, 2025.
Cobalt‐hydride catalyzed enantioconvergent hydroalkylation with allenes and alkenes is achieved with high chemo‐, regio‐, and enantioselectivity. This method allows the streamlined synthesis of enantiomerically enriched C(sp3)–fluorine, –chlorine, and –trifluoromethyl stereocenters.
Uttam Dhawa, Xile Hu
wiley   +2 more sources

Cardiac arrest in a child during a combined general epidural anesthesia procedure [PDF]

open access: yes, 2005
An increased risk of perioperative cardiac arrest in children, in comparison to adults, has been recognized. A number of factors associated with perioperative cardiac arrest have been identified, including young age, comorbidities, and emergency ...
Prabakti, Yudhi   +4 more
core  

Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation. [PDF]

open access: yes, 2014
BackgroundMany anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABAA) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar
Brosnan, Robert J, Pham, Trung L
core   +2 more sources

Iatrogenic pulsus alternans in a dog undergoing median sternotomy

open access: yesVeterinary Record Case Reports, EarlyView.
Abstract A 6‐year‐old, 21.8 kg, female, spayed Siberian husky was referred for management of a spontaneous bilateral pneumothorax, due to a ruptured pulmonary bleb. During surgery, sterile saline was instilled on three occasions in order to locate the damaged lung tissue and ensure complete ligation.
Marie‐Line Doï   +2 more
wiley   +1 more source

HALOTHANE AND THE HEART

open access: yesBritish Journal of Anaesthesia, 1968
SUMMARY The cardiac output fall and the rate changes observed with halothane-oxygen anaesthesia represent a homeostatic adjustment to greater oxygen extraction per unit volume of blood, secondary to 98 per cent oxygen breathing and to a decreased oxygen demand of the anaesthetized patient.
John E. Mazuzan   +2 more
openaire   +3 more sources

The use of low‐dose dexmedetomidine constant rate infusion to stabilise blood glucose in a domestic ferret (Mustela putorius furo) with insulinoma undergoing sevoflurane anaesthesia

open access: yesVeterinary Record Case Reports, EarlyView.
Abstract A 5.5‐year‐old, male domestic ferret (Mustela putorius furo) diagnosed with insulinoma was presented for a dental procedure under general anaesthesia. In insulinoma patients, it is essential to avoid hypoglycaemia. In other species, constant rate infusion of dexmedetomidine has been reported to sustain adequate blood glucose by inhibiting ...
Anika R. Schiele   +3 more
wiley   +1 more source

Halothane Increases Myocardial Sensitivity to Epinephrine-Induced Arrhythmias in Cirrhotic Rats

open access: yesArchives of Anesthesia and Critical Care, 2016
Background: Cirrhotic patients are at a greater risk of different kinds of arrhythmias. Despite the well-known arrhythmogenic effects of halothane, developing countries continue to use halothane due to its low cost. This study was designed to investigate
Mahmoud Gorji valokola   +8 more
doaj  

Molecular genetic analysis for malignant hyperthermia : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry [PDF]

open access: yes, 2004
Malignant hyperthermia (MH) is a rare pharmacogenetic disorder in humans caused by inhalational general anaesthetics and depolarising muscle relaxants. An MH reaction shows abnormal calcium homeostasis in skeletal muscle leading to a hypermetabolic state
Sato, Keisaku
core  

Dobutamine improves haemodynamics and oxygen delivery in standing and isoflurane‐anaesthetised horses

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Dobutamine is a first‐line therapy for hypotension in anaesthetised horses, but the effects on haemodynamic parameters in standing and anaesthetised horses are not well studied. Objectives To investigate the effects of dobutamine in escalating dosages on haemodynamic performance in awake and anaesthetised horses.
Emma B. Gorenberg   +4 more
wiley   +1 more source

Halothane binds to druggable sites in the [Ca2+]4-calmodulin (CaM) complex, but does not inhibit [Ca2+]4-CaM activation of kinase [PDF]

open access: yesJournal of the Serbian Chemical Society, 2013
The mechanism(s) of volatile anesthetics (VA) are poorly understood. We used high resolution NMR spectroscopy to determine the structure of the halothane/calmodulin([Ca2+]4-CaM) complex, and found that halothane molecules bind in the druggable ...
Juranić Nenad O.   +4 more
doaj   +1 more source

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