Results 31 to 40 of about 14,196 (194)

Malignant hyperthermia

Orphanet Journal of Rare Diseases, 2007
Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine ...
Pollock Neil, James Danielle, Davis Mark, Rosenberg Henry, Stowell Kathryn   +4 more
doaj   +1 more source

Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation. [PDF]

, 2014
BackgroundMany anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABAA) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar
Brosnan, Robert J, Pham, Trung L
core   +2 more sources

Electropharmacological Effects of a Spironolactone Derivative, Potassium Canrenoate, Assessed in the Halothane-Anesthetized Canine Model

Journal of Pharmacological Sciences, 2004
While aldosterone receptor blockers improve survival of patients with congestive heart failure, spironolactone and its derivatives were recently shown to block ether-a-go-go-related gene (HERG) channels and native IKs and IKr currents in guinea pig ...
Atsushi Sugiyama, Yoshioki Satoh, Akira Takahara, Kentaro Ando, Kai Wang, Sachiko Honsho, Yuji Nakamura, Keitaro Hashimoto   +7 more
doaj   +1 more source

A new single nucleotide polymorphism in the ryanodine gene of chicken skeletal muscle. [PDF]

, 2017
Some genes affect meat quality in chickens. We looked for polymorphisms in the Gallus gallus α-RyR gene (homologous to RyR 1) that could be associated with PSE (pale, soft and exudative) meat.
BINNECK, E., DROVAL, A. A., MARIN, S. R. R., NEPOMUCENO, A. L., OBA, A., PAIÃO, F. G., SHIMOKOMAKI, M.   +6 more
core   +1 more source

Genetic Factors Affecting Pork Quality: Halothane and Rendement Napole Genes

Animal Biotechnology, 2016
The most common pork quality problems are pale, soft, and exudative (PSE) and acid pork (AP). PSE is associated with the expression of recessive halothane (Hal) allele Haln. Recessive Hal pigs (Halnn) have defective Ca2+ release channels (CRC) or Ryanodine Receptors (RYR1) within the sarcoplasmic reticulum that allow uncontrolled release of Ca2+ in ...
Ramon Cesar D, Salas, Claro N, Mingala
openaire   +2 more sources

Transcription factors and candidate functional SNPs associated with variation in fatty acid composition from skeletal muscle of pigs. [PDF]

Anim Genet
Abstract Pork is an essential source of fatty acids (FAs) in the human diet. Fatty acids are important for various biological processes and can impact transcription regulation. The primary objective of this study was to identify candidate functional single nucleotide polymorphisms (SNPs) and expression quantitative trait loci (eQTL) associated with FA ...
Durval MC, Brito LF, Fanalli SL, Rocha AO, Benfica LF, Ciconello FN, Oliveira CS, Garcia IS, Oliveira Freitas FA, Nascimento LE, Martins da Silva BP, Silva-Vignato B, Cesar ASM.   +12 more
europepmc   +2 more sources

Influence of the halothane gene (HAL) on pork quality in two commercial crossbreeds

Genetics and Molecular Research, 2011
We evaluated the effect of the halothane (HAL) gene on the quality of pork in domestic pigs. Half-carcasses from two different commercial pig (Sus domestica) crossbreeds were analyzed, 46 of which were homozygous dominant (HAL(NN)) and 69 of which were heterozygous (HAL(Nn)) for the halothane gene.
A C P, Silveira, P F A, Freitas, A S M, César, A S M, Cesar, R C, Antunes, E C, Guimarães, D F A, Batista, L C, Torido   +7 more
openaire   +2 more sources

Increased expression of aromatase after focal cerebral ischemia: Relevance to neuroprotection and functional recovery

Neuroprotection, EarlyView.
Abstract Aim Aromatase is the key enzyme in the biosynthesis of 17β‐estradiol, the most potent estrogen, which has pleiotropic neuroprotective properties. Aromatase levels increase in the brain after stroke, and its gene variants increase susceptibility to stroke. This study aims to determine whether aromatase overexpression improves stroke outcome and
Lindsay Gallagher, Anna F. Dominiczak, Luis M. Garcia‐Segura, Nobuhiro Harada, J. B. Hutchison, James M. Mullin, Delyth Graham, Peter O'Shaughnessy, Hilary Victoria O. Carswell   +8 more
wiley   +1 more source

Molecular genetic analysis for malignant hyperthermia : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry [PDF]

, 2004
Malignant hyperthermia (MH) is a rare pharmacogenetic disorder in humans caused by inhalational general anaesthetics and depolarising muscle relaxants. An MH reaction shows abnormal calcium homeostasis in skeletal muscle leading to a hypermetabolic state
Sato, Keisaku
core  

Lifestyle triggers of migraine: Sleep restriction and caffeine lower the threshold for migraine‐like responses in rats in a sex‐specific manner

Headache: The Journal of Head and Face Pain, EarlyView.
Sleep restriction (SR) and caffeine intake act as environmental modulators of migraine susceptibility. Their effects are sex‐dependent: Females show heightened sensitivity under both SR and caffeine conditions. Males require the combination of SR and caffeine to exhibit susceptibility.
Gabriel Camargo de Oliveira, Darciane Favero Baggio, Vanessa Bordenowsky Pereira Lejeune, Laura Storithont Quinelato, Fernanda Mariano Ribeiro da Luz, Aleksander Roberto Zampronio, Luana Fischer, Juliana Geremias Chichorro   +7 more
wiley   +1 more source