Results 61 to 70 of about 37,629 (254)

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

XÁC ĐỊNH NHU CẦU PROTEIN CỦA CÁ KÈO GIỐNG (PSEUDAPOCRYPTES ELONGATUS, CUVIER 1816) Ở HAI MỨC NĂNG LƯỢNG KHÁC NHAU

Tạp chí Khoa học Đại học Cần Thơ, 2014
Nghiên cứu xác định nhu cầu protein của cá kèo giống (Pseudapocryptes elongatus) ở hai mức năng lượng khác nhau được thực hiện nhằm làm cơ sở cho việc nghiên cứu sản xuất thức ăn viên công nghiệp cho cá kèo.
Trần Lê Cẩm Tú, Trang Tuấn Nhi, Dương Kim Loan, Trần Thị Thanh Hiền   +3 more
doaj  

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

CHỌN TẠO DÒNG ĐẬU NÀNH CÓ HÀM LƯỢNG PROTEIN CAO, NGẮN NGÀY VÀ NĂNG SUẤT CAO

Tạp chí Khoa học Đại học Cần Thơ, 2011
Nhằm mục tiêu chọn được các dòng đậu nành mới có hàm lượng protein cao, ngắn ngày và có triển vọng về năng suất. 7 tổ hợp lai đơn giữa giống đậu nành ĐH4 (TGST 75 ngày) và các giống đậu nành địa phương được thực hiện.
Võ Công Thành, Nguyễn Hoàng Tú
doaj  

Predicting the Secondary Structure of Proteins by the Use of Hamming Distances and Alignment Scores

Southeast Europe Journal of Soft Computing, 2014
Researchers are confident about the validity of the basic hypothesis that the secondary and tertiary structures of a protein are uniquely determined by its sequence of amino acids, that is its primary structure. In this article we use a database of 200 proteins.
Mehmet Can, Betul Akcesme, Faruk Berat Akcesme   +2 more
openaire   +2 more sources

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

T cell receptor signaling pathway is overexpressed in CD4+ T cells from HAM/TSP individuals

Brazilian Journal of Infectious Diseases, 2015
Human T-lymphotropic virus type 1 (HTLV-1) is a human retrovirus related to the chronic neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). CD4+ T cells activation appears to play a key role on HTLV-1 infection.
Mariana Tomazini Pinto, Tathiane Maistro Malta, Evandra Strazza Rodrigues, Osvaldo Massaiti Takayanagui, Yuetsu Tanaka, Dimas Tadeu Covas, Simone Kashima   +6 more
doaj   +1 more source

Specificity of intrathecal IgG synthesis for HTLV-1 core and envelope proteins in HAM/TSP

Acta Neurologica Scandinavica, 2009
In patients with human T-cell lymphotropic virus type 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP), we investigated the significance of HTLV-1 specific antibodies in the cerebrospinal fluid (CSF).The quantities of HTLV-1 specific immunoglobulin G (IgG) in paired CSF and serum were evaluated by a sensitive enzyme immunoassay ...
Kitze, B., Puccioni-Sohler, M., Schäffner, J., Rieckmann, P., Weber, T., Felgenhauer, K., Bodemer, W.   +6 more
openaire   +3 more sources

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source