Results 61 to 70 of about 19,908 (281)
Capped antigenomic RNA transcript facilitates rescue of a plant rhabdovirus
Virology Journal, 2017 Background Recovery of recombinant negative-stranded RNA viruses from cloned cDNAs is an inefficient process as multiple viral components need to be delivered into cells for reconstitution of infectious entities.
Shasha Qian +4 more
doaj +1 more source
Langmuir, 2015 Compared with proteins, the relationship between structure, dynamics, and function of RNA enzymes (known as ribozymes) is far less well understood, despite the fact that ribozymes are found in many organisms and are often conceived as "molecular fossils"
J. B. Swadling +3 more
semanticscholar +1 more source
Ribozymes: The hammerhead swings into action [PDF]
Current Biology, 1998 A new crystal structure of a modified hammerhead ribozyme reveals an intermediate conformation that may explain discrepancies between previous structures and the required orientation of the labile bond in the ribozyme's active site.
openaire +3 more sources
A structural analysis of
BMC Bioinformatics, 2007 Background Ribozymes are small catalytic RNAs that possess the dual functions of sequence-specific RNA recognition and site-specific cleavage. Trans-cleaving ribozymes can inhibit translation of genes at the messenger RNA (mRNA) level in both eukaryotic ...
Schneider Erasmus +5 more
doaj +1 more source
Transcription of satellite DNAs in insects [PDF]
, 2011 Chromatin condensation is an important regulatory mechanism of gene silencing as well as gene activation for the hundreds of functional protein genes harbored in heterochromatic regions of different insect species.
D. Ugarkovic +3 more
core +1 more source
Steric Interference Modification of the Hammerhead Ribozyme [PDF]
Chemistry & Biology, 2002 Although the structure of the hammerhead ribozyme is well characterized, many questions remain about its catalytic mechanism. Extensive evidence suggests the necessity of a conformational change en route to the transition state. We report a steric interference modification approach for investigating this change.
Olke C. Uhlenbeck +4 more
openaire +3 more sources
RNA folding and catalysis mediated by iron (II). [PDF]
PLoS ONE, 2012 Mg²⁺ shares a distinctive relationship with RNA, playing important and specific roles in the folding and function of essentially all large RNAs. Here we use theory and experiment to evaluate Fe²⁺ in the absence of free oxygen as a replacement for Mg²⁺ in
Shreyas S Athavale +13 more
doaj +1 more source
The RNA Newton Polytope and Learnability of Energy Parameters [PDF]
, 2013 Despite nearly two scores of research on RNA secondary structure and RNA-RNA interaction prediction, the accuracy of the state-of-the-art algorithms are still far from satisfactory.
Chitsaz, Hamidreza +1 more
core +1 more source
Efficient large-scale preparation and purification of short single-stranded RNA oligonucleotides
BioTechniques, 2016 Sequence-specific RNA recognition by RNA-binding proteins plays a crucial role in the post-translational regulation of gene expression. Biophysical and biochemical studies help to unravel the principles of sequence-specific RNA recognition, but the ...
Maria Zlobina +4 more
doaj +1 more source
Life, 2023 In this study, a tobramycin concentration-dependent whole-cell micro-biosensor (tob-HHAz) was constructed by fusing a tobramycin aptamer with a hammerhead ribozyme (HHR) from Schistosoma mansoni.
Zhenzhen Wang +5 more
doaj +1 more source