Results 71 to 80 of about 16,494 (236)
Biology, 2021 A high pressure apparatus allowing one to study enzyme kinetics under pressure was used to study the self-cleavage activity of the avocado sunblotch viroid.
Hussein Kaddour +4 more
doaj +1 more source
Advanced Engineering Materials, Volume 27, Issue 22, November 2025.Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source
Optimizing (Bio) Catalysis with Liquid‐Liquid Phase Separation Systems
ChemSystemsChem, Volume 7, Issue 6, November 2025.This review highlights how LLPS creates membraneless compartments involved in different scenarios in nature. It further explores different examples that focus on the development of synthetic coacervates that enhance catalytic efficiency by concentrating reactants, or by the direct influence of the coacervates building blocks themselves.
David Q. P. Reis +4 more
wiley +1 more source
RNA Back and Forth: Looking through Ribozyme and Viroid Motifs
Viruses, 2019 Current cellular facts allow us to follow the link from chemical to biochemical metabolites, from the ancient to the modern world. In this context, the “RNA world„ hypothesis proposes that early in the evolution of life, the ribozyme was ...
Marie-Christine Maurel +3 more
doaj +1 more source
Enterovirus A71 DNA-Launched Infectious Clone as a Robust Reverse Genetic Tool. [PDF]
PLoS ONE, 2016 Enterovirus A71 (EV-A71) causes major outbreaks of hand, foot and mouth disease, and is occasionally associated with neurological complications and death in children.
Chee Wah Tan +4 more
doaj +1 more source
Ribozymes: The hammerhead swings into action [PDF]
Current Biology, 1998 A new crystal structure of a modified hammerhead ribozyme reveals an intermediate conformation that may explain discrepancies between previous structures and the required orientation of the labile bond in the ribozyme's active site.
openaire +2 more sources
Factors determining chromosomal localization of transposable elements in plants
Plant Biology, Volume 27, Issue 6, Page 975-989, October 2025.We review transposon chromosomal niches, and the functional consequences of their specific chromosomal localization in plants. Abstract Transposable elements (TEs) constitute a significant part of plant genomes and shape their genomic landscape. While some TEs are ubiquitously dispersed, other elements specifically occupy discrete genomic loci.
E. Kejnovsky +3 more
wiley +1 more source
Hammerhead Ribozymes: True Metal or Nucleobase Catalysis? Where Is the Catalytic Power from?
Molecules, 2010 The hammerhead ribozyme was first considered as a metalloenzyme despite persistent inconsistencies between structural and functional data. In the last decade, metal ions were confirmed as catalysts in self-splicing ribozymes but displaced by nucleobases ...
Fabrice Leclerc
doaj +1 more source
Solvent Structure and Hammerhead Ribozyme Catalysis
Chemistry & Biology, 2008 Although the hammerhead ribozyme is regarded as a prototype for understanding RNA catalysis, the mechanistic roles of associated metal ions and water molecules in the cleavage reaction remain controversial. We have investigated the catalytic potential of observed divalent metal ions and water molecules bound to a 2 A structure of the full-length ...
Martick, Monika +3 more
openaire +3 more sources
Mitochondrial Diseases: Molecular Pathogenesis and Therapeutic Advances
MedComm, Volume 6, Issue 9, September 2025.Key pathogenic mechanisms—OXPHOS defects, heteroplasmy, impaired mtDNA repair, disrupted dynamics/mitophagy, and inflammatory signaling—drive multiorgan involvement in mitochondrial diseases. Targeted interventions include metabolic drugs (CoQ10, idebenone, EPI‐743), mitochondrial gene editing (DdCBE, mitoBEs, CyDENT/mitoTALEN/mtZFN), and mitochondrial
Jialun Mei +6 more
wiley +1 more source