Enhanced RNA knockdown efficiency with engineered fusion guide RNAs that function with both CRISPR-CasRx and hammerhead ribozyme. [PDF]
Genome Biol, 2023 Zhan Y, Cao C, Li A, Mei H, Liu Y.
europepmc +1 more source
Meeting review : ESF workshop on "Impact of nucleic acid chemistry on gene function analysis: antisense, aptamers, ribozymes and RNAi" [PDF]
, 2008 The shortage of functional information compared to the abundance of sequence information characterizes today’s situation in functional genomics. For many years the knock-down of a gene’s product has been the most powerful way of analysing its function ...
Engels, Joachim W. (Prof. Dr.) +3 more
core
Life on Minerals: Binding Behaviors of Oligonucleotides on Zirconium Silicate and Its Inhibitory Activity for the Self-Cleavage of Hammerhead Ribozyme. [PDF]
Life (Basel), 2022 Kawamura K +5 more
europepmc +1 more source
The model structure of the hammerhead ribozyme formed by RNAs of reciprocal chirality. [PDF]
Biosci Rep, 2021 Wyszko E +8 more
europepmc +1 more source
Ribozymes of the RNA World: Investigating Ancient Enzymes through Modern Self-Cleaving Ribozymes. [PDF]
, 2016 Ribozymes are RNAs that can perform catalytic functions. The discovery of ribozymes was an important milestone in science because it not only opened new avenues of research but also provided insights into the origins of life on Earth.
Mir, Aamir
core +1 more source
A High-Pressure, High-Temperature Flow Reactor Simulating the Hadean Earth Environment, with Application to the Pressure Dependence of the Cleavage of Avocado Viroid Hammerhead Ribozyme. [PDF]
Life (Basel), 2022 Kawamura K +8 more
europepmc +1 more source
Ribozymes: the characteristics and properties of catalytic RNAs [PDF]
, 2017 Ribozymes, or catalytic RNAs, were discovered a little more than 15 years ago. They are found in the organelles of plants and lower eukaryotes, in amphibians, in prokaryotes, in bacteriophages, and in viroids and satellite viruses that infect plants.
Tanner, N. Kyle
core
Plant Biotechnology Journal, Volume 22, Issue 10, Page 2950-2953, October 2024.
Subhasis Karmakar +11 more
wiley +1 more source
Cellular delivery of hammerhead ribozymes [PDF]
, 1997 Hammerhead ribozymes are potent RNA molecules which have the potential to specifically inhibit gene expression by catalysing the trans-cleavage of mRNAs. However, they are unstable in biological fluids and cellular delivery poses a problem. Site-specific chemical modification of hammerhead ribozymes was evaluated as a means of enhancing biological ...
openaire +1 more source
Single Mutation in Hammerhead Ribozyme Favors Cleavage Activity with Manganese over Magnesium. [PDF]
Noncoding RNA, 2020 Naghdi MR +4 more
europepmc +1 more source