Results 141 to 150 of about 399,690 (387)

A recurrent neural network for soft sensor development using CHO stable pools in fed‐batch process for SARS‐CoV‐2 spike protein production as a vaccine antigen

open access: yesBiotechnology Progress, EarlyView.
Abstract Fed‐batch recombinant therapeutic protein (RTP) production processes utilizing Chinese Hamster Ovary (CHO) cells can take a long period of time (>10 days). Within this period, not all critical features may be measured routinely, and in fact, some are only measured once the process is terminated, complicating decision making.
Sebastian‐Juan Reyes   +4 more
wiley   +1 more source

Laser Microirradiation of Chinese Hamster Cells at Wavelength 365 nm [PDF]

open access: yes, 1981
Cells of a V79 subline of the Chinese hamster were microirradiated at wavelength 365 nm in the presence of the psoralen derivative, trioxsalen. Microirradiation was accomplished by a pulsed argon laser microbeam either in anaphase or in interphase 3 hr ...
Berns, Michael W.   +3 more
core  

Impact of bioreactor process parameters and yeast biomass on Raman spectra

open access: yesBiotechnology Progress, EarlyView.
Abstract In‐line Raman spectroscopy combined with chemometric modeling is a valuable process analytical technology (PAT) providing real‐time quantitative information on cell culture compounds. Considering that compound quantification through chemometric models depends on pre‐processing to maintain consistent changes in intensity at certain wavenumbers,
Maarten Klaverdijk   +3 more
wiley   +1 more source

Nearly Fuchsian surface subgroups of finite covolume Kleinian groups

open access: yes, 2020
Let Gamma < PSL_2(C) be discrete, cofinite volume, and noncocompact. We prove that for all K > 1, there is a subgroup H < Gamma that is K-quasiconformally conjugate to a discrete cocompact subgroup of PSL_2(R).
Kahn, Jeremy, Wright, Alex
core  

Study of radiation effects on mammalian cells in vitro [PDF]

open access: yes, 1968
Radiation effect on single cells and cell populations of Chinese hamster lung tissue is studied in vitro. The rate and position as the cell progresses through the generation cycle shows division delay, changes in some biochemical processes in the cell ...
Sinclair, W. K.
core   +1 more source

Harvesting AAV by tangential flow filtration using reverse asymmetric membranes

open access: yesBiotechnology Progress, EarlyView.
Abstract Efficient bioreactor clarification for harvesting virus particles is often challenging. Tangential flow filtration is attractive as it can be easily adapted for batch and perfusion operations. Here the feasibility of using reverse asymmetric hollow fiber membranes, where the more open support structure faces the feed stream, has been ...
Xiaolei Hao   +5 more
wiley   +1 more source

Enhancing rapid Protein A performance in monoclonal antibody processing: Anion exchange chromatographic clarification

open access: yesBiotechnology Progress, EarlyView.
Abstract Clarification fidelity, including reduction of insoluble and soluble contaminants, has been demonstrated to significantly affect the performance and robustness of the Protein A capture chromatography step during the purification of monoclonal antibodies (mAb) and their derivatives expressed in CHO cell cultures.
Andrew Vail   +3 more
wiley   +1 more source

Promising Prodiginins Biological Activities

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto   +6 more
wiley   +1 more source

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