Results 181 to 190 of about 306,860 (343)

Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study

open access: yesEpilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which converts 3‐phosphoglycerate to generate serine and the neurotransmitter glycine, with (drug‐resistant ...
Karin Thevissen   +25 more
wiley   +1 more source

A simplified protocol for vitrification of hamster embryos. [PDF]

open access: yesJ Reprod Dev
Hirose M   +7 more
europepmc   +1 more source

Drug discovery and preclinical testing of drug candidates for developmental and epileptic encephalopathies

open access: yesEpilepsia, EarlyView.
Abstract Drug development for developmental and epileptic encephalopathies (DEEs) follows different strategies on one hand including disease‐targeting precision medicine approaches considering the genetic variants and pathomechanisms in DEEs and on the other hand including therapeutic approaches with novel targets or second‐generation drug candidates ...
Heidrun Potschka, Daniel Pérez‐Pérez
wiley   +1 more source

Blood group O expression in normal tissues and tumors

open access: yesThe FEBS Journal, EarlyView.
The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4‐31L and OmcFL3‐02, specifically detect the H antigen on glycan microarrays, glycoproteins, and human cells.
Ea Kristine Clarisse Tulin   +11 more
wiley   +1 more source

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