Results 191 to 200 of about 399,690 (387)

Exogenous oxidized phytosterol may modulate linoleic acid metabolism through upregulation of fatty acid desaturase in rats

open access: yesLipids, EarlyView.
Abstract Previous in vitro studies have indicated that oxidized phytosterol (OPS) exhibits some toxicity; however, the harmful effects of OPS on fatty acid metabolism are not completely understood yet. Therefore, this study examined the effects of exogenous phytosterol (PS) and OPS on growth parameters and lipid metabolism in rats.
Tomonari Koyama, Kyoichi Osada
wiley   +1 more source

From In Vitro Efficacy to Long‐Term HbA1c Response for GLP‐1R/GlucagonR Agonism Using the 4GI‐HbA1c Systems Model

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
A combined systems model (4GI‐HbA1c) was developed to predict glucose and HbA1c responses to GLP‐1 and GLP‐1/glucagon receptor agonists using early pharmacokinetic and in vitro efficacy data. Validated with short‐term CGM data, the model accurately predicted 26‐week clinical outcomes for liraglutide and cotadutide, demonstrating its value in supporting
Rolien Bosch   +5 more
wiley   +1 more source

Diet-Induced Metabolic Improvements in a Hamster Model of Hypercholesterolemia Are Strongly Linked to Alterations of the Gut Microbiota

open access: yesApplied and Environmental Microbiology, 2009
I. Martínez   +7 more
semanticscholar   +1 more source

Insights Into Effects of Natural Bioactive Components on Inflammatory Diseases in Respiratory Tract

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT The increasing prevalence of inflammatory diseases in the respiratory tract worldwide has raised concerns, and due to its high prevalence and poor prognosis, it remains a clinical focus and research hotspot. These inflammatory diseases include airway inflammation, asthma, bacterial antigens‐induced tonsil epithelial inflammation, chronic ...
Jincan Luo   +4 more
wiley   +1 more source

The Internal Nanostructure of Lipid Nanoparticles Influences Their Diverse Cellular Uptake Pathways

open access: yesSmall, EarlyView.
Lipid nanoparticles are vital for drug delivery, but their cellular interactions remain unclear. This study shows that non‐lamellar lyotropic liquid crystalline nanoparticles (LLCNPs) ‐ including cubosomes, hexosomes, and micellar cubosomes ‐ preferentially use passive pathways like membrane fusion, bypassing endocytic recycling faced by lamellar ...
Sue Lyn Yap   +7 more
wiley   +1 more source

Xenogeneic humoral Graft-Vs-Host disease following hamster-to-rat bone marrow transplantation [PDF]

open access: yes, 2000
Fung, JJ   +8 more
core   +1 more source

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